Avantika Gupta
@avantikagupta.bsky.social
π€ 69
π₯ 81
π 22
Postdoc @MSKCC studying mutagenesis and resistance mechanisms in cancer
pinned post!
So excited to share our latest work with
@saratchandarlapaty.bsky.social
, Antonio Marra, Andrea Gazzo
@mskcancercenter.bsky.social
out today in
@natgenet.nature.com
! We uncover the function and mechanism of APOBEC3-driven therapy resistance in breast cancer. π§΅ 1/
www.nature.com/articles/s41...
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APOBEC3 mutagenesis drives therapy resistance in breast cancer - Nature Genetics
Analysis of a large cohort of metastatic breast cancer samples shows that APOBEC mutational signatures are enriched in post-treatment samples. APOBEC activity was also associated with mutations known ...
https://www.nature.com/articles/s41588-025-02187-1
6 months ago
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Amazing to have our work featured on the cover of the latest issue of
@natgenet.nature.com
! The artwork, like the science, is a collaborative creation with everyoneβs fingerprints π
www.nature.com/articles/s41...
add a skeleton here at some point
5 months ago
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reposted by
Avantika Gupta
Sarat Chandarlapaty
5 months ago
Published online today - work led by Yanyan Cai: Inhibition of NR2F2 restores hormone therapy response to endocrine refractory breast cancers | Science Translational Medicine
www.science.org/doi/10.1126/...
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Inhibition of NR2F2 restores hormone therapy response to endocrine refractory breast cancers
NR2F2 modulates the ER cistrome, coregulator interactions, and chromatin accessibility to promote endocrine resistance in ER+ breast cancer.
https://www.science.org/doi/10.1126/scitranslmed.adk7786
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reposted by
Avantika Gupta
Sarat Chandarlapaty
6 months ago
Published online today - work from our team led by Avantika Gupta, revealing how APOBEC3 mutagenesis promotes resistance to several targeted therapies in breast cancer. Check it out!
urldefense.com/v3/__https:/...
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APOBEC3 mutagenesis drives therapy resistance in breast cancer
Nature Genetics - Analysis of a large cohort of metastatic breast cancer samples shows that APOBEC mutational signatures are enriched in post-treatment samples. APOBEC activity was also associated...
https://urldefense.com/v3/__https://rdcu.be/emjaq__;!!KVWo1iE!WvNZ8mm-2M8SSRGbMJpzlqh5nKDm9b9xbwXp5vWS-OZj1lb7Ym1fKkDpdkhuxS-lwiHtWiA-BxYfHcpuinbMhB56WTffy0us$
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So excited to share our latest work with
@saratchandarlapaty.bsky.social
, Antonio Marra, Andrea Gazzo
@mskcancercenter.bsky.social
out today in
@natgenet.nature.com
! We uncover the function and mechanism of APOBEC3-driven therapy resistance in breast cancer. π§΅ 1/
www.nature.com/articles/s41...
loading . . .
APOBEC3 mutagenesis drives therapy resistance in breast cancer - Nature Genetics
Analysis of a large cohort of metastatic breast cancer samples shows that APOBEC mutational signatures are enriched in post-treatment samples. APOBEC activity was also associated with mutations known ...
https://www.nature.com/articles/s41588-025-02187-1
6 months ago
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@saratchandarlapaty.bsky.social
expertly summarizing our work on how underlying genomic instability in breast cancer leads to therapy resistance leaving with key ideas on how we might target them! Come see me expand on the role of APOBEC3 mutagenesis in these processes tomorrow morning at
#AACR25
!
7 months ago
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Congratulations to
@reikudo.bsky.social
for the beautiful work inspiring current+future studies!
#SABCS24
11 months ago
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So honored to have gotten the opportunity to present our work showing a prevalent role of APOBEC3 mutagenesis in driving therapy resistance in breast cancer at
#SABCS24
!
11 months ago
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reposted by
Avantika Gupta
Matt Sikora
11 months ago
Great work from Dr Avantika Gupta in
@saratchandarlapaty.bsky.social
lab, linking APOBEC mutagenesis to facilitating therapy resistance in HR+ breast cancer. Lots of intriguing vulnerabilities to target that would be relevant in a lot of breast cancers!
#SABCS24
www.biorxiv.org/content/10.1...
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APOBEC3 mutagenesis drives therapy resistance in breast cancer
Acquired genetic alterations commonly drive resistance to endocrine and targeted therapies in metastatic breast cancer[1][1]β[7][2], however the underlying processes engendering these diverse alterati...
https://www.biorxiv.org/content/10.1101/2024.04.29.591453v1
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reposted by
Avantika Gupta
Sarat Chandarlapaty
11 months ago
Fantastic presentation
#SABCS
by
@avantikagupta.bsky.social
on apobec3 in breast cancer. Demonstrating the role of this process in promoting therapy resistance.
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Congratulations to
@caiy0219.bsky.social
for an excellent poster presentation today! ππ½ Also, so happy to be reunited with
@reikudo.bsky.social
to represent the translational team in
@saratchandarlapaty.bsky.social
βs lab at
#SABCS2024
!
11 months ago
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@marie-will.bsky.social
expertly setting up a major research focus and our latest work identifying a new resistance mechanism and a rational strategy to improve the efficacy of the HER2
#ADC
T-DXd. Please check it out here:
www.cell.com/cell-reports...
add a skeleton here at some point
12 months ago
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