🥳 I am happy to share our latest manuscript published in @natcellbio.nature.com We use #Gastruloids to study #CellCompetition during early mammalian development and find not only that this is highly pronounced in our system but also tightly restricted in time. (1/12) www.nature.com/articles/s41...

Insights from derivation of human IPS #stemcell derived islet-like or off-target enterochromaffin (EC)-like cells in the pancreas #diabetes www.nature.com/articles/s41...

Excited to share our new paper in Nat Comms on how human stem cell-derived pancreatic progenitors choose between islet and enterochromaffin (EC)-like fates - and how we can steer that choice! A story in a few tweets… Full paper 👉 doi.org/10.1038/s414...

Hot off the press! This paper provides protocols for directed differentiation of hPSCs to different pancreatic islet-like endocrine cells as well as to enterochromaffin cells. Congratulations to the whole team! www.nature.com/articles/s41...

(🧵10/18) Works from Feb+March 2026🍀. From Dr. M. Cristina Nostro: “Efficient control of enterochromaffin versus islet differentiation from human pluripotent stem cell-derived pancreatic progenitors” PMID 41851084 www.nature.com/articles/s41...

So excited to hear about Hypoimmune islet transplants from Sonja Schrepfer from Sana Biotechnology - without immunosuppression Is this the future for cell therapy in diabetes? @albertadiabetes.bsky.social celebrating the 25th anniversary of the Edmonton Protocol #25EP

Some chapters are harder to get out that others. This was like birthing an elephant. But it's great. Channel your enthusiasm: Chapter 19 part 1, Metabolic Acidosis www.rosebook.club/episodes/202...

Pretty exciting! I wonder how long the effect will last…

Article In Press! Can gene therapy help prevent rejection? AAV-mediated PD-L1 delivery during cold storage was associated with reduced acute rejection in a rat lung transplant model. www.amjtransplant.org/article/S160...

Well done! Congrats from the east 😎

🧬 Excited to share our latest study now In Press: In this study led by rising star @sarahcolpitts.bsky.social, we show that IL-10⁺ #ILC2s prevent rejection and improve islet graft survival and function in humanized mouse models. Read more: doi.org/10.1016/j.aj... #Immunology #ImmunoSky #CellTherapy

Interesting anecdote when a patient shows up with a ChatGPT differential diagnoses list 😏 www.ajkd.org/article/S027... @ajkd.bsky.social

A greater understanding of hypoxia’s impact on stem cell-derived #islets offering a potential intervention for clinical applications #T1D @natcomms.nature.com www.nature.com/articles/s41...

📢 Register now! Annual Transplant Research and Education Conference 📅Thurs June 5, 2025 - Fri June 6, 2025 📍Toronto (Virtual option available) More details and to register: bit.ly/ATCEduResDay @uhn.ca @uhnresearch.ca @uoftmedicine.bsky.social #education #transplant #research

Recording up on our channel now youtu.be/e85gl9RydBM #NephGR #NephSky

Excited to enroll our first participant for testing an agent (tolimidone) we hope will promote beta cell regeneration, building on preclinical work from Dr Jean Buteau at @albertadiabetes.bsky.social. Supported by Alberta Diabetes Foundation & biodexa pharmaceuticals www.ualberta.ca/en/folio/202...

Although a lot of work still to do, a great step forward for pluripotent stem cell-based therapies for kidney disease!