WTF

Told Cleo that I submitted an R01 today. She is not impressed.

Insane, enterprise-destroying, proposed regulations

Lots of folks are posting about these proposed changes. Good. Next step is to write to your representatives. Talk to your scientific society about what it can do.

I ride transit frequently and have voted for many tax levies to fund its expansion in Seattle. The Sound Transit board choosing to build meandering, low-ridership extensions while deferring the one with the potential to serve the most people makes me angry www.seattletimes.com/seattle-news...

Thrilled to announce that the Department of Microbiology at the University of Washington, School of Medicine is hiring at the Assistant Professor level (tenure-track)! The Pacific Northwest is an awesome place to live and do science 🧪🦠. Join us! apply.interfolio.com/185622 Applications due 8/1.

Seattle cat prefers sunlight

Supreme Court Holds, 6-3, That Black People Voting Violates Rights Of White Voters

Bacterial immune proteins have repeatedly evolved to become parts of eukaryotic immunity. But how? Our new preprint uncovers a recent horizontal transfer event & shows how eukaryotes co-opted a toxic bacterial immune protein 🦠🧪🧵 1/

Chicago, from the sky Credit: my son

Check out the newest issue of JB! Check out our minireviews on gliding motility, P. aeruginosa virulence, plant pathogenesis, thermoregulation in P. aeruginosa, Synechocystis, N regulagion and Mycobacterium tuberculosis as a model system. journals.asm.org/toc/jb/208/4 @asm.org #JBacteriology

New lab paper! Kiki Bellamoroso, Maxim Kostylev, and Nicole Smalley describe how robust activation of quorum sensing might be detrimental for cooperation in bacteria, and found an interesting variant of the P. aeruginosa quorum sensing transcription factor LasR. journals.asm.org/doi/10.1128/...

Holy New York.

The full 2 Line is OPEN

@hsiehyp.bsky.social and Ian O’Keefe’s recent paper presented as a “Research highlight” in Nature Reviews Microbiology www.nature.com/articles/s41...

Magnesium depletion by Candida albicans unleashes two unusual modes of colistin resistance in Pseudomonas aeruginosa with different fitness costs. @hsiehyp.bsky.social, Robert Ernst lab, @ajaidandekar.bsky.social, my lab. journals.plos.org/plosbiology/... ipmb.sinica.edu.tw/en/activitie...

Nearly perfectly square sheet of fungus (contamination!) in media

I did accomplish something today

New paper 🔔 Collaboration @sullivan-lab.bsky.social Marissa Gittrich led the work Klebsiella phage biology has focused almost entirely on capsulated strains, but capsule loss is the #1 resistance mechanism under phage predation. We used a naturally acapsular host to reveal the receptor landscape

Cool @sound-transit.bsky.social merch for kid 2’s wall

Congratulations, @hsiehyp.bsky.social! The first paper from the newly-minted Hsieh lab at Academia Sinica.

@soundersfc.com Seems like there’s room for improvement at managing security lines before the game? I’ve been here a while 😬 The blue and green trees are pretty

On a 2 train for the first time! … and really looking forward to the east side connection

~100% chance the President is going to do something totally bonkers this weekend.

BREAKING: The Supreme Court STRIKES DOWN Trump's "emergency" tariffs. The vote is 6–3. www.supremecourt.gov/opinions/25p...

Finally a good push notification

LFGGGGGG!!! 🔥 Congratulations, Seahawks!!

Definitely did not call “1st TD of the game would be Barner in the 4th quarter”

I simply would not choose Mike Tyson as the spokesperson for anything

Adding complexity with three foci (Epstein, racist memes, ICE) now

"the staffer posted the racist meme" is the new "Trump struck a softer tone" in terms of media credulousness

A reminder for the reviewers of #NIHGrants "Nice" NIH study sections screw their applicants because of the way NIH calculates percentile. drugmonkey.wordpress.com/2025/11/20/n...

New lab preprint! Andrew Frando, Bobby Parsek, and Graham Roberts describe how components of the quinolone quorum sensing circuit of P. aeruginosa interact in competition with another Gram-negative bacterium, S. maltophilia -- it's a three-component AND logic gate. www.biorxiv.org/content/10.6...

They are failing politically but all of these people must be brought to account. There is no justice in allowing them to slink away quietly

States must at least try to hold the rogue federal government accountable!

I’m mystified by the need for direct-to-consumer pharma ads generally, but one for a cancer radiotherapy is truly ridiculous

House Appropriations minibus bill funding NIH is out now. - $400M increase - Multiyear funding of new awards capped at 2025 levels. - No line item for BRAIN Initiative text here: docs.house.gov/billsthiswee... Screenshots from Dem summary and Sec 240 (multiyear funding text).

Reminder for those applying for #NIH grants using the #ScienCV templates. You can format the text sections using html codes: <p> paragraph <br> break line <b>bold</b> <i>italics</i>

Happy new year everyone! Resistance is not futile.

I think some folks might be happy to see this. NIGMS MIRA R35 for EI/NI has been published. PAR-26-121 files.simpler.grants.gov/opportunitie...

Everybody thinks this is a World Cup draw but really it's just a meme-generation show!

They made him a trophy that looks like the World Cup -- which he has admired -- but only bigger and goldener

“Next, the World Cup draw. But first, we will introduce every player from every qualified team”

P. aeruginosa giant microbe keeping a watchful pair of eyes from our tree

Happy Thanksgiving!

Before rideshare, the only cities in the country where someone could go out and confidently expect to hail a cab afterwards were Chicago and (of course) New York

The University at Albany Biomedical Sciences Department is hiring at the Assistant Professor level. We are looking for researchers at the intersection of infectious disease and artificial intelligence: albany.interviewexchange.com/jobofferdeta... #infectiousdisease #artificialintelligence