89% of patients with Mast Cell Activation Syndrome (MCAS) had significant reduction in symptoms from GLP-1RAs. It is thought that these drugs stabilize mast cells and reduce inflammation. The authors recommend future randomized trials of these drugs in patients with #LongCOVID.

Facinating article about Dr. Michael Peluso, MD, an infectious disease clinician and researcher, as well as the director and one of the co-creators of the large Long Term Impact of Infection with Novel Coronavirus (LIINC) project at UCSF. #LongCovid

The Bateman Horne Center published a new Clinical Care Guide for managing #ME/CFS, #LongCOVID and Infection-associated chronic conditions (IACCs). The guide offers advice on common comorbidities, assessment tools, clinical pearls, and treatments for these very complex diseases.

Two years later, 18 #LongCOVID patients still showed increased sympathetic nerve activity, vascular dysfunction, impaired exercise capacity. Elevated markers of endothelial stress + oxidative damage point to the cardiovascular effects that may underlie persistent fatigue & shortness of breath.

On finding treatments for #LongCovid “What’s so sad here is people are so desperate, and we don’t have anything [of so many solid candidates] validated." gift link: www.washingtonpost.com/wellness/202...

Nicotinamide, an NAD precursor, also shows promise in helping #LongCovid symptoms.

Saw my new cardiologist a few days ago for #LongCovid issues (PEM, POTS). Two techs walk in, unmasked. I politely ask them to wear masks. “What?! Me?!” Yes, please. You. Why must this always be an issue? So tired of negotiating every. single. thing.

Coffee, #LongCovid, and fatigue.

Published research from Harvard’s Mass. General Hospital reveals that 8 weeks of regular mindfulness practice physically thickens brain regions involved in bodily awareness, while simultaneously reducing activity in the brain circuit responsible for mind-wandering and self-referential thinking. (1)

Using single-cell analysis, scientists in China uncovered widespread changes in alternative polyadenylation of mRNA in brain-related cells after COVID. These disruptions may contribute to neurological and psychiatric symptoms observed in #LongCOVID patients. www.biorxiv.org/content/10.1...

A preprint from Germany reports that 68 individuals with #LongCOVID had unusually active CD8+ T cells and elevated IL-3 levels. These immune signatures could help identify patients at risk and guide development of targeted therapies. www.sciencedirect.com/science/arti...

A preprint study from Mount Sinai found that 57% of Respiratory Long COVID patients with ongoing shortness of breath showed signs of heart and lung inflammation nearly a year after infection, even when standard tests were normal. (1)

A systematic review/meta-analysis of nearly 140k participants found that excess weight is linked to increased risk of neurological symptoms in #LongCOVID. Fat tissue may serve as a reservoir for the virus, contributing to prolonged symptoms. journals.plos.org/plosone/arti...

The Schmidt Initiative for #LongCovid announced a clinical trial to test AstraZeneca’s monoclonal antibody Sipavibart as a treatment for Long COVID. The randomized, placebo-controlled trial builds on earlier reports of Long COVID remission after monoclonal antibody use. silc.org/news/clinica...

Key finding about cold exposure for #LongCovid: It’s not the temperature so much as how cold it *feels* to you.

Pentadecanoic Acid (C15:0, aka Fatty15) and Its Potential Role in #LongCovid.

#Covid may increase the long-term risk of cancer, per a pre-print from UC San Francisco & NIH researchers. Scientists evaluated blood from almost 130 participants and found immune and metabolic damage in people with #LongCOVID. www.medrxiv.org/content/10.1...

A study in The Journal of Virology found #Covid can persist in the semen for at least 6 months, and “the male genital tract may be a reservoir for the virus.” A Scientific Reports study of 900+ participants found #Covid was associated with lower sperm counts, reduced mobility, and DNA damage.

Five years disabled w/ #LongCovid has turned me into a research machine as well as a guinea pig as I trial things that might help. Just over my latest flare, 16 days. Profound exhaustion is worst symptom. Stopped all supplements & am restarting one at a time, 3 mos. at a time, to test each.

So I’ve been researching methylene blue for help with symptoms of #longCOVID, specifically exhaustion, but also brain fog. Used Google’s research AI (Gemini Deep Research), which can scrape info from the ‘net better/faster than I can. Here’s its results— gemini.google.com/app/da0b6eee...

Dr. Oz to run #Medicare and #Medicaid? This administration is a horror show of malignant stupidity.

While there remains no single study that confirms that persistent virus is the cause of #LongCovid, collectively several recent key papers make a compelling case. Antivirals can help. theconversation.com/long-covid-a...

In lab models using whole blood, adding vitamin B12 reduced the overexpression of CCL11 by modifying its DNA methylation profile. This helped normalize pro-inflammatory and neuroprotective genes, indicating vitamin B12’s potential role in managing VCD. #LongCovid www.nature.com/articles/s41...

Higher prevalence of tinnitus, anxiety, and cognitive fatigue was observed in the #PASC cohort. #LongCovid www.nature.com/articles/s41...

A large nutritional intervention study involving #LongCovid patients showed that boosting the diet with plant-based foods, in combo with a specific lactobacillus probiotic and inulin prebiotic, reduced symptoms, improved gut health, and sped recovery. phyto-v.com

Immune Helpers for #Covid, #LongCovid 🥒 Fermented Foods 🥦 High-Fiber Foods 🥬 Dark Leafy Greens 🍊 Citrus Fruits 🥜 Nuts and Seeds 🫚 Ginger 🧄 Garlic 🫐 Berries 🧀 Probiotic-Rich Foods 🦴 Bone Broth

“Many who live with severe & #painful conditions can only manage 1 ‘big’ activity a day, especially if it involves leaving the house. If that day has a medical visit for example, everything pivots on that single activity”: buff.ly/3wXcPEN by @apainprincess.bsky.social #ChronicPain #ChronicFatigue

Teas for brain health. #LongCovid #Brainfog Green Tea: Contains L-theanine & caffeine; improves focus & reduces mental fatigue. Turmeric Tea: Combines anti-inflammatory & neuroprotective properties. Ginkgo Biloba Tea: Enhances blood flow to the brain, improving concentration & memory. (more)

#LongCovid brain fog? Here’s a list of foods that support brainpower. (Source: Harvard Health) www.health.harvard.edu/healthbeat/f...

#LongCovid & electrolytes—Results showed a significant association between electrolyte supplementation & improvements in heart rate variability parameters. Electrolyte supplementation also linked to reduction in premature contractions & improved quality of life. www.frontiersin.org/journals/car...

Hopeful #LongCovid news on regaining smell and taste. www.theguardian.com/society/2025...

This is hopeful news for people with #LongCovid. I watched a YouTube video of a Japanese woman self-administering EAT. Even though it looks uncomfortable, experiencing less exhaustion would be life-changing. pmc.ncbi.nlm.nih.gov/articles/PMC...

We Need Mandatory Masking in Healthcare, and We Need it Now! Healthcare facilities should set the tone when it comes to masking. They should help patients protect themselves from #Covid and other threats. Instead they push droplet dogma and put lives at risk

- #COVID winter wave declining more slowly than previous years -Current vaccines very effective against severe outcomes + reduce transmission -Adults 65+ should consider getting 2nd 2024-2025 vax after 6 mos., or sooner if big plans/events/risks -COVID can accelerate coronary artery plaque growth

We’ll be seeing some grim years for #LongCovid research under Trump. As reported in The Sick Times, STAT News: -Issued and executive order to terminate the Secretary's Advisory Committee on Long COVID -Removed Long COVID info and data from federal websites -Is attacking research at the NIH

Japanese researchers have developed a peptide that prevents #COVID19 by binding to spike proteins. Inexpensive, easily synthesized, potentially side-effect free, can be stored at room temperature and administered through inhalation. www.japantimes.co.jp/news/2025/01...

PubMed is down. But a similar European site is available. Since I use PubMed for the majority of my #LongCovid and #ME/CFS research, I’ll be switching until America is back online, four years from now. europepmc.org

#LongCovid brain fog? Swimming boosts memory. A Journal of Physiology study found swimming strengthens neural pathways essential for memory and learning. Buoyancy reduces stress on the body while significantly increasing circulation, oxygen, and nutrients to support memory and cognitive function.

A recent study found inspiratory training improved autonomic functioning, sleep, pain, heart rate variability, and resting heart rate in #ME/CFS and #LongCovid, and even improved the distance the participants covered in the 6-minute walk test. www.healthrising.org/blog/2024/12...

Researchers have identified a nanobody that effectively neutralizes all tested Omicron subvariants, SARS-CoV-1, & pangolin coronavirus. This has potential as an intranasal prophylactic & could help with development of a universal vaccine against current & future sub-viruses. -Ruth Ann Crystal, MD

Horrific News: Health and Human Services federal advisory committee on #LongCOVlD was ordered on 2/19/25 to terminate within 14 days. Link to HHS site: bit.ly/4ia0yz0 Link to White House order that rejects our fight against Long COVlD: bit.ly/4h6TTVn Write to your representatives! Take action!

When #disability becomes a cautionary tale, it segues to ableism. It’s then used as a symbol of fear mongering, shoring up notions of able-bodiedness, whiteness, & nationhood, to protect the able-bodied who remain. This leads to a xenophobic or fascist environment. -Sunaura Taylor #LongCovid #ME/CFS

Harriet McBryde Johnson: disabled people take conditions that people would never ask for and make beautiful, thriving lives out of them. We have to remind ourselves that there will always be disabled people living thriving lives. There will always be moments of beauty and joy. #LongCovid #ME/CFS

Handy info — Pacing and Management Guide for people living with #ME/CFS and #LongCovid

"you don't look sick."

A RECOVER study finds that #longCOVID produces more people with #ME/CFS than previously thought. Plus, HealthRising took a deep, deep dive into RECOVER and came to the surprising conclusion that the huge Long Covid initiative may end up being quite helpful. www.healthrising.org/blog/2025/01...

Webpages on #LongCOVID disability accommodations, incl ADA resources, have been removed from the Dept of Labor website following Trump purges. Disability advocates say legal protections remain, but this makes it harder for us to access crucial info about rights and workplace accommodations.

Last year, Rob Wust’s lab wrote a paper in Nature magazine showing that muscle abnormalities worsen after PEM in people with #LongCOVID. This week, Ranque et al. posted a reply stating they believe the muscle abnormalities are due to deconditioning rather than exercise-induced muscle damage. 1/2

37 studies of almost 3 million people shows more than 15% of #COVID patients have chest pain, palpitations, and hypertension. Patients with #LongCovid also report chest pain, palpitations, and high blood pressure. bmcmedicine.biomedcentral.com/articles/10....

"Individuals who are hospitalized, who are pretty sick, or who had bird exposure — we are subtyping," said Hamilton County Public Health Medical Director Dr. Stephen Feagins. "It's a matter of time until we see some more human cases. And so we want to be looking for it rather than waiting for it."