'The role of #endolysosomal #progranulin and #TMEM106B in neurodegenerative diseases' Hideyuki Takahashi & Stephen M. Strittmatter molecularneurodegeneration.biomedcentral.com/articles/10....

Prevail Tx/Lilly's investigational AAV gene therapy PR006 that delivers progranulin into brains of patients w/ rare form of dementia/FTD has shown promise in an early safety trial. Nature Biotech story says 6 companies are pursuing the progranulin pathway to potentially treat frontotemporal dementia

I am so very proud announce my lab's first preprint!! @xiaoyucaly.bsky.social delves into the mechanisms driving tau distribution: * Tau sequence driven by connectivity dynamics * Tau load driven by local factors Check out her thread below

🧠 Can we defeat dementia? This week, BNA President @tspiresjones.bsky.social took the TEDx stage to explore the powerful neuroscience that could help us do just that. 🎥 Watch her talk here: youtu.be/hJMEAd9ODis #TEDx #Neuroscience #Dementia #BNA

Disease-modifying effects of TMEM106B in genetic frontotemporal dementia: a longitudinal GENFI study #RareDisease #Genetics academic.oup.com/brain/advanc...

I'm happy to share that our paper describing our novel TMEM106B overexpression mouse model is now out in Molecular Neurodegeneration 🧠📝. It’s been a project with highs and lows, and seeing it published is incredibly rewarding. Thanks to everyone who was part of the journey 🙌.

📣 Exciting new paper! The Da Cruz lab created a novel TDP-43 model by seeding TDP-43 fragments, recapitulating both cytoplasmic aggregation and nuclear clearance — key hallmarks of the pathology. www.cell.com/neuron/fullt...

A genetic medicine that delivers progranulin into the brains of patients with a rare form of dementia has shown promise in an early safety trial. At least six companies are pursuing the progranulin pathway to treat frontotemporal dementia www.nature.com/articles/s41... rdcu.be/eboPa