Glad to see @davidmcquarrie.bsky.social paper #genetics showing that core promoters of Drosophila "prostata" genes evolve fast which can leading to allelic dominance.

Doing CRISPR - check out our PlatinumCRISPr upgrade thanks to @roliarnold.bsky.social and @ihaussmann.bsky.social platinum-crispr.bham.ac.uk

FTO depletion does not alter m6A stoichiometry in AML mRNA: a reassessment using direct RNA nanopore sequencing https://www.biorxiv.org/content/10.1101/2025.10.22.681652v1

A breakthrough reporting delay the progression of Huntington's Disease!! www.bbc.co.uk/news/article...

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

Thrilled to share a new preprint from the lab! We investigated how m6A regulates the transcriptome in chemoresistant glioblastoma through unexpected mechanisms, and the potential therapeutic applications of this discovery. Check out the preprint here ⬇️ www.biorxiv.org/content/10.1...

Hey, and what about #Drosophila?

Fascinating new insights on co-transcriptional m6A deposition - before splicing!

We paid ~£80 to validate our CRISPR edit - still a good price. www.biorxiv.org/content/10.1...

Excited to share our new paper describing how ELAV/Hu RNA binding proteins achieve binding specificity now in NAR thanks to fantastic @davidmcquarrie.bsky.social academic.oup.com/nar/article/...