AND IT'S DONE! A 🧵 on our recent article now out in @natsmb.nature.com! Co-led with @abbybartlett.bsky.social, Pagliarini Lab, @judisimcox.bsky.social, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯 doi.org/10.1038/s415...

Happy Pi Day! MVH Lab's two delicious contributions to Pi day:

Looking at human kidney cancer, we profiled nutrient levels in the tumor environment and found they are similar to nutrient levels in healthy kidney tissue, suggesting tumors must work within constraints of nutrients available rather than change nutrient environment. elifesciences.org/articles/95652

Published a few weeks ago in Cancer Research, we show benefit of targeting HMCR with pitavastatin in combo with AKT inhibitors in TNBC. Many amazing people contributed, led by the magnificently talented @alissandra-hillis.bsky.social! Looking to initiate new clinical trials based on this combo. 🧪

Great to be posting science again!! Very proud of this work, thanks to a wonderful collaboration with Forest White lab at MIT, Cantley lab at DFCI, and leb by the amazingly talented @alissandra-hillis.bsky.social! Published as fully @openaccess.bsky.social in PNAS. www.pnas.org/doi/10.1073/...