Maximilian Frey
@maximilianfrey.bsky.social
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📥 384
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Lecturer Biochemistry Center Heidelberg University
reposted by
Maximilian Frey
Nature
about 2 months ago
KJ Muldoon, at less than a year old, was the first known person to receive a personalised CRISPR-based genome-editing therapy He is part of Nature’s 10, a list of people who shaped science in 2025
go.nature.com/48GqTl3
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The baby whose life was saved by the first personalized CRISPR therapy
KJ Muldoon is part of Nature’s 10, a list of people who shaped science in 2025.
https://go.nature.com/48GqTl3
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Maximilian Frey
Nature Portfolio
about 2 months ago
GLP-1 drugs can help people lose weight by quelling hunger queues. Nature reports on the work by scientists testing if these drugs can help to cut cravings for cigarettes, alcohol and opioids. 🧪
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Will blockbuster obesity drugs revolutionize addiction treatment?
Scientists are testing whether GLP-1 drugs can help to cut cravings for cigarettes, alcohol and opioids — as well as food.
https://go.nature.com/48rjFCF
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Maximilian Frey
Fernanda Petersen
about 2 months ago
Denmark just mapped its entire environmental microbiome. More than 10,000 samples revealing hidden, dominant nitrifiers that shape fertilizer use, water quality, and climate impact. A national microbiome atlas could transform sustainable agriculture across Europe.
#AMR
www.nature.com/articles/s41...
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The Microflora Danica atlas of Danish environmental microbiomes - Nature
Microflora Danica—an atlas of Danish environmental microbiomes—reveals that although human-disturbed habitats have high alpha diversity, species reoccur, revealing hidden homogeneity.
https://www.nature.com/articles/s41586-025-09794-2
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Happy to see our review published in issue 11 of Natural Products Reports. 😊
add a skeleton here at some point
about 2 months ago
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Maximilian Frey
Natural Product Reports
about 2 months ago
🔓Don't miss in our latest issue this
#OpenAccess
review by
@maximilianfrey.bsky.social
& co.
@ipbhalle.bsky.social
,
@unihalle.bsky.social
&
@mpi-ce.bsky.social
looking at the biosynthesis of biologically active terpenoids in the mint family
#naturalproducts
#secmet
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Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae)
Covering: 2000 to 2025 The Lamiaceae family, the sixth largest among angiosperms, is renowned for its rich diversity of terpenoids, many of which exhibit remarkable bioactivities, including…
https://pubs.rsc.org/en/content/articlelanding/2025/np/d5np00026b
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The MassBank contributions of the mFam Consortium A Global Push to Boost Coverage and Diversity of MassBank
chemrxiv.org/engage/api-g...
Happy to have contributed.
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https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/68dfa95c5dd091524fb32f3f/original/the-mass-bank-contributions-of-the-m-fam-consortium.pdf
3 months ago
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Maximilian Frey
The book "Natural Product Isolation and Identification" is now online. Happy to contribute to a protocol: "Extraction of Essential Oils and Terpene Volatiles from Plants and Identification by GC-MS-Based Techniques" (Krause & Frey, 2025)
link.springer.com/protocol/10....
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Extraction of Essential Oils and Terpene Volatiles from Plants and Identification by GC-MS-Based Techniques
The extraction of plant essential oils (EOs) and analysis by gas chromatography coupled to mass spectrometry (GC-MS) are standard methods when studying aromatic plants and the chemical composition of ...
https://link.springer.com/protocol/10.1007/978-1-0716-4350-1_6
12 months ago
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Maximilian Frey
- Elucidation of a biosynthetic route to xanthanolide sesquiterpene lactones:
onlinelibrary.wiley.com/doi/abs/10.1...
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An independent biosynthetic route to frame a xanthanolide‐type sesquiterpene lactone in Asteraceae
Xanthanolide-type sesquiterpene lactones (STLs) are promising candidates for anti-cancer drug development. Since the middle of the last century, when the structure of the first xanthanolide-type STL ...
https://onlinelibrary.wiley.com/doi/abs/10.1111/tpj.17199
12 months ago
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Maximilian Frey
Our review paper on sesquiterpene lactones was published one year ago in February 2024. Since then there have been some fascinating developments in the field: Full article: Sesquiterpene Lactones – Insights into Biosynthesis, Regulation and Signalling Roles
www.tandfonline.com/doi/full/10....
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Sesquiterpene Lactones – Insights into Biosynthesis, Regulation and Signalling Roles
Sesquiterpene lactones (STLs) are bitter tasting plant specialized metabolites derived from farnesyl pyrophosphate (FPP) that contain a characteristic lactone ring. STLs can be found in many plant ...
https://www.tandfonline.com/doi/full/10.1080/07352689.2024.2307240
12 months ago
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Maximilian Frey
www.mdpi.com/1420-3049/30...
We just published the paper "Cytochrome P450-Induced Backbone Rearrangements in Terpene Biosynthesis of Plants" in Molecules. Thanks to everyone involved. :)
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https://www.mdpi.com/1420-3049/30/17/3540
5 months ago
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Maximilian Frey
pubs.rsc.org/en/content/a...
We just published the paper Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae) in Natural Products Reports. Thanks to everyone involved! :)
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Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae)
Covering: 2000 to 2025The Lamiaceae family, the sixth largest among angiosperms, is renowned for its rich diversity of terpenoids, many of which exhibit remarkable bioactivities, including anti-inflam...
https://pubs.rsc.org/en/content/articlelanding/2025/np/d5np00026b
5 months ago
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www.mdpi.com/1420-3049/30...
We just published the paper "Cytochrome P450-Induced Backbone Rearrangements in Terpene Biosynthesis of Plants" in Molecules. Thanks to everyone involved. :)
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https://www.mdpi.com/1420-3049/30/17/3540
5 months ago
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pubs.rsc.org/en/content/a...
We just published the paper Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae) in Natural Products Reports. Thanks to everyone involved! :)
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Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae)
Covering: 2000 to 2025The Lamiaceae family, the sixth largest among angiosperms, is renowned for its rich diversity of terpenoids, many of which exhibit remarkable bioactivities, including anti-inflam...
https://pubs.rsc.org/en/content/articlelanding/2025/np/d5np00026b
5 months ago
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reposted by
Maximilian Frey
Nature
6 months ago
This AI model can predict where ancient Latin texts come from, estimate how old they are and restore missing parts
go.nature.com/4lLQwGr
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Meet Aeneas: the AI that can fill in the gaps of damaged Latin texts
The best results come when a human and the model work together.
https://go.nature.com/4lLQwGr
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reposted by
Maximilian Frey
IPB Halle
8 months ago
Und auch unsere Expertin Mariana Schuster
@marischuster.bsky.social
könnt ihr am 3.6. ausfragen, wie das Immunsystem bei Pflanzen funktioniert und warum das überhaupt wichtig ist. 🥬💚(Auf 🇩🇪 oder 🇬🇧) 👉Hier
#BookAScientist
buchen:
www.leibniz-gemeinschaft.de/ueber-uns/ne...
#wisskomm
#PlantSci
#scicomm
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reposted by
Maximilian Frey
Natural Product Reports
9 months ago
🎉We are delighted to welcome Professor Neha Garg
@ngarg10.bsky.social
from
@gtresearchnews.bsky.social
to the
@natprodreports.rsc.org
Editorial Board!
#chemsky
#natprod
Learn more about Neha here🔽
blogs.rsc.org/np/2025/04/0...
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Maximilian Frey
Uni Halle
10 months ago
Lässt sich der Nährwert von Gerste steigern? Wie können Pflanzen mehr Zellulose bilden? Fragen wie diese stehen im Zentrum des neuen Forschungsverbunds „Value Plant“ der Uni Halle, der mit rund 7,1 Mio. Euro gefördert wird. Verbundsprecher ist Prof. Dr. Ingo Heilmann von der MLU.
mlu.de/6evf0
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Maximilian Frey
Boas Pucker
10 months ago
Celebrating the 10-year anniversary of my Python for Life Scientists course at Uni Bonn! 🎉 Proud to have shared coding skills with so many researchers over the years. 📂 Slides are available on GitHub:
github.com/bpucker/PyBo
#Python
#LifeScience
#OpenScience
#Teaching
@puckerlab.bsky.social
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Maximilian Frey
Jonathan D G Jones aka JJ
11 months ago
European Union takes giant leap forward toward embracing technologically-enhanced agriculture, advances de-regulation of gene edited crops
geneticliteracyproject.org/2025/03/17/e...
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European Union takes giant leap forward toward embracing technologically-enhanced agriculture, advances de-regulation of gene edited crops
On Friday 14 March 2025, Member States' representatives (Coreper) endorsed the Council's negotiating mandate on the regulation on plants obtained by new genomic techniques (NGTs) and their food and fe...
https://geneticliteracyproject.org/2025/03/17/european-union-takes-giant-leap-forward-toward-embracing-technologically-enhanced-agriculture-advances-de-regulation-of-gene-edited-crops/
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Maximilian Frey
Boas Pucker
11 months ago
Wrapping up our Applied Plant Transcriptomics course! From RNA-seq to de novo transcriptome assembly.
#Bioinformatics
#PlantSciences
📑 Slides available here:
github.com/bpucker/Appl...
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reposted by
Maximilian Frey
Andrea Sinz 🧪
11 months ago
🧪 In these days, we all need some positive news 😀: Check out our latest work that has tremendous impact on patients’ lives. That’s why we all need science!🧪 A big thank you to all coauthors! 👏👏
@unihalle.bsky.social
@unileipzig.bsky.social
#Academicsky
#MedSky
#ADCY5
@standupforscience.bsky.social
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reposted by
Maximilian Frey
Michelle Wille
11 months ago
What a title! "This is the way the world ends; not with a bang but a whimper: Estimating the number and ongoing rate of extinctions of Australian non-marine invertebrates" Biodiversity declines really concerning. 👉
www.cambridge.org/core/journal...
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Maximilian Frey
Nature Metabolism
11 months ago
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Discovery of metabolites prevails amid in-source fragmentation
Nature Metabolism, Published online: 28 February 2025; doi:10.1038/s42255-025-01239-4Discovery of metabolites prevails amid in-source fragmentation
https://bit.ly/41LxRCP
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Maximilian Frey
Team_Zuccaro
11 months ago
Latest story from Pia Saake: Plant Lipids Mediate Immune Responses to Fungal Lipids in Barley!
nph.onlinelibrary.wiley.com/doi/full/10....
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Ergosterol‐induced immune response in barley involves phosphorylation of phosphatidylinositol phosphate metabolic enzymes and activation of diterpene biosynthesis
Lipids play crucial roles in plant–microbe interactions, functioning as structural components, signaling molecules, and microbe-associated molecular patterns (MAMPs). However, the mechanisms underly...
https://nph.onlinelibrary.wiley.com/doi/full/10.1111/nph.70022
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Maximilian Frey
Plantae.org
11 months ago
#BlackHistoryMonth
Plant Scientist Spotlight - Meet Sibongile Mafu!🌱 👉 See the full list of incredible plant scientists
featured at buff.ly/41fCJQn #plan
#plantscience
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Maximilian Frey
SNP2Prot
11 months ago
Let’s kick off this kick-off! Today and tomorrow we are meeting at the
@ipbhalle.bsky.social
to officially start the
#snp2prot
journey as a team 💪
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Our review paper on sesquiterpene lactones was published one year ago in February 2024. Since then there have been some fascinating developments in the field: Full article: Sesquiterpene Lactones – Insights into Biosynthesis, Regulation and Signalling Roles
www.tandfonline.com/doi/full/10....
loading . . .
Sesquiterpene Lactones – Insights into Biosynthesis, Regulation and Signalling Roles
Sesquiterpene lactones (STLs) are bitter tasting plant specialized metabolites derived from farnesyl pyrophosphate (FPP) that contain a characteristic lactone ring. STLs can be found in many plant ...
https://www.tandfonline.com/doi/full/10.1080/07352689.2024.2307240
12 months ago
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Maximilian Frey
Boas Pucker
12 months ago
Many thanks for visiting us and sharing your exciting stories
add a skeleton here at some point
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Maximilian Frey
Andrea Sinz 🧪
12 months ago
🧪If you join our lab you will be able to use our three timsTOF mass spectrometers….and we also got a new microwave oven for our lab kitchen today!😜
#ChemSky
#AcademicSky
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Maximilian Frey
Andrea Sinz 🧪
12 months ago
Job alert 🧪 ‼️ Hi
#teammassspec
: In our
#RTG2467
@unihalle.bsky.social
we have a job opening for a PhD student in my group! 🎉 If you want to do cool stuff in cross-linking mass spectrometry of the tumor suppressor p53, please take a look:
personal.verwaltung.uni-halle.de/jobs/wissmi/
Please RT!
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Externe Stellenausschreibungen- Wissenschaftliche Mitarbeiterinnen und Mitarbeiter, Ärzte und Lehrkräfte für besondere Aufgaben
http://personal.verwaltung.uni-halle.de/jobs/wissmi/
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Maximilian Frey
Kaptorga - Visual History
12 months ago
And industry since has been like: "Hold my beer!"
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Maximilian Frey
Andrea Sinz 🧪
12 months ago
‼️Altogether we are hiring 12 PhD students in
#RTG2467
on intrinsically disordered proteins. Please take a look at our job advertisements❗️
@unihalle.bsky.social
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Uni Halle (@unihalle.bsky.social)
Stabsstelle Zentrale Kommunikation der Uni Halle. Impressum: https://uni-halle.de/impressum
https://unihalle.bsky.social
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Maximilian Frey
The Plant Journal
12 months ago
𝐍𝐞𝐰 𝐢𝐧 𝐓𝐏𝐉 The cis-prenyltransferase protein family in Taraxacum koksaghyz 👉doi.org/10.1111/tpj.17233 by Müller, Niephaus et al Comprehensive description of cis-prenyl transferases in this rubber-producing plant that aid in breeding & protein design
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Maximilian Frey
Boas Pucker
12 months ago
Cornflowers are famous for their brilliant blue color. This genome sequence provides a valuable resource for studying the genetics of this striking flower. Read more:
doi.org/10.1101/2025...
#Genomics
#FlowerColor
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reposted by
Maximilian Frey
Stefan Koldehoff
12 months ago
"Es gibt keinen Zusammenhang zwischen Herkunft und Gewalt -Deutschland ist sehr sicher": Unendlich wichtiger Text von Prof. Christian Stöcker über die völlig verzerrte Migrationsdebatte und ihre Folgen. Bitte unbedingt lesen.
www.spiegel.de/wissenschaft...
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Meinung: Migration: Friedrich Merz fällt auf den Psychotrick der AfD herein
Das Narrativ vom »gefährlichen Ausländer« gehört zum Markenkern der AfD. Sie hat es mit langem Atem strategisch in den Mainstream eingeschleust und die Union überlistet: mit gezielter Realitätsverzerr...
https://www.spiegel.de/wissenschaft/mensch/migration-friedrich-merz-faellt-auf-den-psychotrick-der-afd-herein-a-f76a4721-bc6f-4a5e-aff8-845eaa45c058
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The book "Natural Product Isolation and Identification" is now online. Happy to contribute to a protocol: "Extraction of Essential Oils and Terpene Volatiles from Plants and Identification by GC-MS-Based Techniques" (Krause & Frey, 2025)
link.springer.com/protocol/10....
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Extraction of Essential Oils and Terpene Volatiles from Plants and Identification by GC-MS-Based Techniques
The extraction of plant essential oils (EOs) and analysis by gas chromatography coupled to mass spectrometry (GC-MS) are standard methods when studying aromatic plants and the chemical composition of ...
https://link.springer.com/protocol/10.1007/978-1-0716-4350-1_6
12 months ago
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Maximilian Frey
bioRxivpreprint
about 2 years ago
Metabolome and transcriptome profiling of root chicory provide insights into laticifer development and specialized metabolism https://www.biorxiv.org/content/10.1101/2024.01.02.573856v1
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Metabolome and transcriptome profiling of root chicory provide insights into laticifer development and specialized metabolism https://www.biorxiv.org/content/10.1101/2024.01.02.573856v1
Chicory roots produce inulin, a dietary fiber, as well as large quantities of bitter sesquiterpene l
https://www.biorxiv.org/content/10.1101/2024.01.02.573856v1
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Maximilian Frey
Alain Tissier
almost 2 years ago
Happy to share our latest publication. More than 200 diterpenoids producex by combinatorial biosynthesis using 10 diterpene synthases and 4 P450 oxygenases in yeast:
www.sciencedirect.com/science/arti...
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Maximilian Frey
Alain Tissier
almost 2 years ago
Thrilled to see our work on improving gene targeting frequencies in plants by fusing 5' exonucleases to CRISPR/Cas endonucleases finally published. Awesome team effort with tremendous contribution by project leader Tom Schreiber
www.cell.com/molecular-pl...
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Maximilian Frey
Alain Tissier
about 1 year ago
We're looking for a postdoc and a technical assistant in a 3-year project funded by the DFG in collaboration with Sophien Kamoun (TSL) and Silvia Restrepo (Boyce Thompson Institute). Genome editing in potato to generate new resistance against late blight. Deadline 30/01.
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Joboffer Detail: Leibniz-Institut für Pflanzenbiochemie
https://www.ipb-halle.de/en/career/job-vacancies/joboffer-detail/wissenschaftliche-r-mitarbeiter-in-fightblight-bioengineering-von-immunrezeptoren-zur-resistenz-gegen-die-kartoffelfaeule-mwd-272024/
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reposted by
Maximilian Frey
Alain Tissier
about 1 year ago
Attention! The IPB is looking for a new Head of Department in a joint appointment (W3 Professorship) with the University of Halle. This is an exceptional position. Come join us and shape the future of the IPB!
berufungsportal.uni-halle.de
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Welcome - Login | Appointment Portal
https://berufungsportal.uni-halle.de/
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