Michaela Schwaiger
@xxxmichixxx.bsky.social
📤 105
📥 248
📝 4
Computational Biologist
reposted by
Michaela Schwaiger
Current Biology
10 days ago
But can they scratch their backs with them?😂
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So true!
add a skeleton here at some point
3 months ago
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reposted by
Michaela Schwaiger
Hans-Rudolf Hotz
5 months ago
contact me or
@csoneson.bsky.social
if you want more details
add a skeleton here at some point
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reposted by
Michaela Schwaiger
FMI science
5 months ago
The Max Burger Prize 2025 goes to Josip Ahel (
@aheljo.bsky.social
), Aparna Pandey & Michaela Schwaiger for adding a key piece to the puzzle of how cells protect the DNA from “jumping genes.” Read more at
www.fmi.ch/news-events/...
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reposted by
Michaela Schwaiger
Marc Bühler
5 months ago
We are hiring-join us!
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reposted by
Michaela Schwaiger
FMI science
5 months ago
🚨 Job Alert: we seek a Lab Manager for
@juliabatki.bsky.social
's new group (start Mar 2026), which will study cell fate regulation during organ development. Join the Batki's group to drive experiments & lab operations! Apply at:
www.fmi.ch/education-ca...
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reposted by
Michaela Schwaiger
Josip Ahel
7 months ago
🧵 New preprint! How does a chromatin remodeler know where to act? In our latest study, we show how the transcription factor ADNP targets CHD4 remodeling activity to silence transposons and block CTCF. 👇 A thread on the ChAHP complex and how it weaves chromatin 🧬🔬🧵
www.biorxiv.org/content/10.1...
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Remodeling Activity of ChAHP Restricts Transcription Factor Access to Chromatin
Transcription in eukaryotes is regulated by chromatin-based mechanisms that control nucleosome occupancy, chromatin modifications, and transcription factor binding. We have previously shown that the transcription factor ADNP forms the ChAHP complex with the chromatin remodeler CHD4 and HP1 proteins, acting as a site-specific regulator of transcription and antagonist of CTCF binding. However, the molecular basis of these functions remained unclear. Here, we demonstrate that the CHD4 subunit is essential to antagonize CTCF and silence transcription of transposons, while HP1 proteins are dispensable. Although the remodeling activity of CHD4 is not required for ChAHP chromatin association, it is critical for both transposon repression and CTCF antagonism. Our findings support a model wherein ADNP recruits chromatin remodeling activity in a sequence-specific manner, enabling transcriptional control and local modulation of chromatin architecture. ### Competing Interest Statement The Friedrich Miescher Institute for Biomedical Research (FMI) receives significant financial contributions from the Novartis Research Foundation. Published research reagents from the FMI are shared with the academic community under a Material Transfer Agreement (MTA) having terms and conditions corresponding to those of the UBMTA (Uniform Biological Material Transfer Agreement). Novartis Research Foundation, n.a. Swiss National Science Foundation, grant 310030_188835
https://www.biorxiv.org/content/10.1101/2025.07.03.662926v1
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reposted by
Michaela Schwaiger
Jakob Schnabl-Baumgartner
7 months ago
More ChAHP within the same week! Check out the work from
@aheljo.bsky.social
dissecting the molecular activities within the complex
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reposted by
Michaela Schwaiger
Marc Bühler
7 months ago
preprint alert:
www.biorxiv.org/content/10.1...
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Remodeling Activity of ChAHP Restricts Transcription Factor Access to Chromatin
Transcription in eukaryotes is regulated by chromatin-based mechanisms that control nucleosome occupancy, chromatin modifications, and transcription factor binding. We have previously shown that the transcription factor ADNP forms the ChAHP complex with the chromatin remodeler CHD4 and HP1 proteins, acting as a site-specific regulator of transcription and antagonist of CTCF binding. However, the molecular basis of these functions remained unclear. Here, we demonstrate that the CHD4 subunit is essential to antagonize CTCF and silence transcription of transposons, while HP1 proteins are dispensable. Although the remodeling activity of CHD4 is not required for ChAHP chromatin association, it is critical for both transposon repression and CTCF antagonism. Our findings support a model wherein ADNP recruits chromatin remodeling activity in a sequence-specific manner, enabling transcriptional control and local modulation of chromatin architecture. ### Competing Interest Statement The Friedrich Miescher Institute for Biomedical Research (FMI) receives significant financial contributions from the Novartis Research Foundation. Published research reagents from the FMI are shared with the academic community under a Material Transfer Agreement (MTA) having terms and conditions corresponding to those of the UBMTA (Uniform Biological Material Transfer Agreement). Novartis Research Foundation, n.a. Swiss National Science Foundation, grant 310030_188835
https://www.biorxiv.org/content/10.1101/2025.07.03.662926v1
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Check out our latest preprint on the regulation of SINE retrotransposons! 🐭
add a skeleton here at some point
7 months ago
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reposted by
Michaela Schwaiger
Hans-Rudolf Hotz
7 months ago
Earlier today
@csoneson.bsky.social
from
@fmiscience.bsky.social
gave a great keynote at this year's
#gbcc2025
conference
@bioconductor.bsky.social
@galaxyproject.bsky.social
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reposted by
Michaela Schwaiger
Merle Skribbe
11 months ago
www.sciencedirect.com/science/arti...
I am very excited to share our latest work on the protein and chromatin interactomes of transcription factors! 🧬 Huge thanks to everyone who contributed, especially
@csoneson.bsky.social
and
@mbstadler.bsky.social
for driving this story with me! 🙌
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A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin
Transcription factors (TFs) are key regulators of gene expression, yet many of their targets and modes of action remain unknown. In Schizosaccharomyce…
https://www.sciencedirect.com/science/article/pii/S1097276525000991?via%3Dihub
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reposted by
Michaela Schwaiger
Michael Stadler
about 1 year ago
Permanent position for a Linux Systems Engineer: Are you fond of scientific computing and/Linux/HPC and would enjoy working in a vibrant research environment? Have a look at our job opening:
www.fmi.ch/education-ca...
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Friedrich Miescher Institute, open position
Friedrich Miescher Institute, open position
https://www.fmi.ch/education-careers/positions/jobdetails.html?jobID=308
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reposted by
Michaela Schwaiger
Hans-Rudolf Hotz
about 1 year ago
Our IT (at
@fmiscience.bsky.social
) group is looking for a Linux Systems Engineer. This is an interesting opportunity to work in a diverse research environment.
www.fmi.ch/education-ca...
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Friedrich Miescher Institute, open position
Friedrich Miescher Institute, open position
https://www.fmi.ch/education-careers/positions/jobdetails.html?jobID=308
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reposted by
Michaela Schwaiger
FMI science
about 1 year ago
📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at:
www.fmi.ch/education-ca...
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