Jack Sanford
@jacksanfordphd.bsky.social
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Postdoc in the Goncalves lab. Studying cancer cachexia and tumor secreted proteins.
Today is the first cancer cachexia day. Please share to spread awareness. For patients, these are symptoms to keep track of and let your doctor know if you are experiencing. For medical professionals, a big hurdle is dietitian visits are not commonly reimbursed, despite benefiting patients
9 days ago
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Authors, please upload a gene count matrix or even t-test excel sheet in your paper. I don’t want to have to download the raw counts
11 days ago
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Jack Sanford
Stand Up for Science!
18 days ago
You asked for it! We delivered Quack-O-Grams to our members of Congress urging them to #ImpeachRFK, and get that Quack out of office! There's still time for you to get in on this fluffy, feathery action: Send your own duck at
zurl.co/W1ZnB
#ImpeachRFK
and keep the momentum going! 🦆
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Jack Sanford
Nikolai Slavov
22 days ago
Contrasting cell count and biomass distributions by cell type: ◼️ Human cell size and count are nearly inversely related. More quantitatively, ... 🧵
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Massive study just published for the field of appetite control! Now only if we could harness it! (Check out the video at the end)
www.cell.com/cell/fulltex...
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A brain center that controls consummatory responses
The BNST brain region integrates a broad range of external and internal signals to flexibly regulate consumption, revealing a unified control over consummatory responses.
https://www.cell.com/cell/fulltext/S0092-8674(25)00976-6
24 days ago
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Phospholipid looking like a wacky inflatable tube man
add a skeleton here at some point
25 days ago
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Jack Sanford
Michael MacCoss
3 months ago
The Mag-Net paper is out! We've now put 1000s of plasma samples through this protocol and we know others have too. We've used it to study dozens of diseases. Looking forward to seeing what others apply this towards. The preprint already has >39 citations.
www.nature.com/articles/s41...
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Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome - Nature Communications
Authors report MagNet, a plasma extracellular vesicle (EV) enrichment strategy using magnetic beads. Proteomic interrogation of this plasma EV fraction enables the detection of proteins that are beyon...
https://www.nature.com/articles/s41467-025-60595-7
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Incredible! Once/year HIV prevention injection
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7 months ago
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Well said. This will not stop at Columbia.
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7 months ago
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I made my NCAA bracket based on how much each university received in funding from the NIH last year. The NIH funds incredible, life saving research at all of these universities that we cheer for.
7 months ago
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Really interesting findings. My interpretation: Large, high profile research groups create a survival of the fittest mentality. Those who survive do quite well, but many end up dropping out of academia
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7 months ago
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Jack Sanford
Derek Lowe
7 months ago
The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:
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A Bifunctional Degrader Reads Out in Phase 3
https://www.science.org/content/blog-post/bifunctional-degrader-reads-out-phase-3
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We need to change how we talk about the NIH funding another vaccines and autism study. Don’t say “this is settled science, we already studied this” Talk about the opportunity cost. We are NOT going to find the next cancer causing agent because we are studying this instead
7 months ago
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Eating a western diet during pregnancy is associated with ADHD and autism development in offspring.
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7 months ago
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Got my sign ready for the
#StandUpForScience
march in DC! Hope to see many of you out there!
7 months ago
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Jack Sanford
Carolyn Bertozzi
7 months ago
It is important at this pivotal moment to
@standupforscience.bsky.social
. Looking forward to sharing my thoughts on why this should be a national priority at tomorrow’s rally in SF:
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Jack Sanford
jp flores (he/him)
7 months ago
What Hank said!
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I was lucky enough to have been one of these interns. Not only did this program give me practical experience that helped me get into a PhD program, but it was as an NIH intern that I learned that I loved science. What a loss.
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7 months ago
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Jack Sanford
Itai Yanai
8 months ago
We have to stand up for science! Anyone who can join these rallies and believes that US science must be protected should come!
@standupforscience.bsky.social
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Just signed up to attend the March 7th Stand up for Science march in DC. Similar marches happening at state capitals nationwide. Now is the time to double down on science. Not cut back. Make your voice heard on March 7th.
www.standupforscience2025.org/STAND-UP-FOR...
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STAND UP FOR SCIENCE 2025
Join us in Washington, DC or your state capitol on March 7th, 2025 to stand up for science!
https://www.standupforscience2025.org/STAND-UP-FOR-SCIENCE-2025-1965a8bd7a44806a8182dc6b75b80da2
8 months ago
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Cancer is non-partisan. Cardiovascular disease is non-partisan. This will be devastating if not resolved quickly.
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9 months ago
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Jack Sanford
Nikolai Slavov
9 months ago
A Quantitative Proteome Map of the Human Body .
www.cell.com/cell/fulltex...
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A Quantitative Proteome Map of the Human Body
Proteomics analysis across human tissues from the GTeX resource reveals insight into tissue-specific pathways and phenotypes arising from genetic diseases.
https://www.cell.com/cell/fulltext/S0092-8674(20)31078-3
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I’m finding a lot of proteins in my blood proteomics work that have no known secretion pathway. Proteins like histone subunits, parts of the nuclear pore complex, and proteosome subunits. Does anyone know how these get into the blood stream? It has to be cell turnover, right?
9 months ago
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Jack Sanford
Dr. Al
10 months ago
All these pipelines for spatial transcriptomics really need to be aware of this. Don't turn your expensive output into a puddle.
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Jack Sanford
Brendon Neuen
10 months ago
Clear ⏬ with GLP-1RA by ~15% for all clinical outcomes including: Kidney failure ✅ Major CV events ✅ Heart failure ✅ CV death ✅ All-cause death ✅ Updated systematic review/meta-analysis of 11 trials ~85,000 participants, with & without diabetes Now in Lancet D&E:
www.thelancet.com/journals/lan...
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My parents were very confused when I excitedly told them about my first citation 😅
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10 months ago
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Also proudly represented team CANCAN at the Cancer Grand Challenges future leaders symposium in Barcelona. It was a blast meeting everyone and exploring such a gorgeous city! (Pics of Sagrada Familia)
10 months ago
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Recently presented my work on identifying LPS-induced lung secreted proteins at the Cancer Cachexia Action Network (CANCAN) symposium at CSHL. Thanks everyone for the wonderful feedback!
10 months ago
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