Becky Lamason (@lamasonlab.bsky.social)

Our collaborative work investigating the interaction between a Rickettsia parkeri secreted effector and clathrin is online in the December issue of Infection and Immunity. Thanks also to the editors for selecting it as an article of significant interest! journals.asm.org/doi/10.1128/...

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A conserved interaction between the effector Sca4 and host clathrin suggests additional contributions for Sca4 during rickettsial infection | Infection and Immunity Intracellular bacterial pathogens must adapt to a host cell environment to enable their growth, survival, and dissemination. Consequently, they have evolved various mechanisms to manipulate their host environments to create a more hospitable niche (1–5). One common way for pathogens to interact with host cells is through surface-associated and secreted effector proteins. Bacterial pathogen effectors are known to exert diverse functions, including inducing cellular invasion, establishing vacuolar compartments, remodeling host organelles, modifying the host immune response, and facilitating the spread of these pathogens between cells (6–11). https://journals.asm.org/doi/10.1128/iai.00267-24