Jordi Xiol
@jordixiol.bsky.social
📤 739
📥 320
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Science, history, and drug development |
https://vineyardbooks.substack.com/
pinned post!
How did life on Earth begin? Recent scientific advances suggest that all living beings are descended from a single gene that appeared around 4 billion years ago. New blog post Adam and Eve Existed: They Created the Genetic Code
www.vineyardbooks.blog/p/adam-and-e...
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Adam and Eve Existed: They Created the Genetic Code
How did life on Earth begin? Recent scientific advances suggest that all living forms are descended from a single gene that existed around 4 billion years ago. This gene encoded for two proteins that ...
https://www.vineyardbooks.blog/p/adam-and-eve-existed-they-created
over 1 year ago
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Big pharma is heading to Barcelona and here's why
www.bloomberg.com/news/newslet...
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Big Pharma Is Heading to Barcelona and Here’s Why
Hello, it’s Ashleigh in London, where I’ve been trying to solve the mystery of why Big Pharma is flocking to Spain (and no, it’s not just for the sun, sea and paella). More on that in a bit, but first...
https://www.bloomberg.com/news/newsletters/2025-04-04/here-s-why-astrazeneca-azn-and-other-big-pharma-giants-are-flocking-to-spain
7 months ago
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reposted by
Jordi Xiol
Christian Odendahl
7 months ago
Nobel Prizes by country and year. The dominance of Germany is striking every time. Before 1933, that is. And the utter dominance of America (and the UK) after 1945.
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Jordi Xiol
Wikipedia
7 months ago
"In a minefield of glitchy AI search and social media, Wikipedia becomes one of the most reliable places on the internet" Read more, via CNN Business ➡️
edition.cnn.com/2025/01/14/b...
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Nobody's talking about the fact that some anonymous hero included Jeffrey Goldberg in that Signal group chat. Lighting the way
7 months ago
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GSK allegedly just tipped the feds that Pfizer intentionally delayed releasing its Covid vaccine Phase 3 data until after the 2020 election. A very risky move by GSK that could seriously backfire, regardless of whether the accusation is true
www.wsj.com/health/pharm...
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Exclusive | U.S. Prosecutors Probe Tip About Timing of Pfizer Vaccine
The inquiry is looking into a politically explosive suggestion that Pfizer delayed announcing a successful vaccine against Covid-19 until after the election that Trump lost to Biden.
https://www.wsj.com/health/pharma/pfizer-covid-vaccine-2020-election-probe-2f3ec247?st=iL6Zpw&reflink=desktopwebshare_permalink
7 months ago
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🎙️Podcast 1957 - La URSS lanza el satélite Sputnik y desata la carrera espacial con Estados Unidos 2025 - DeepSeek revela la competitividad de China en inteligencia artificial Momento DeepSeek: En este episodio analizamos el auge de China en clave biotech
open.spotify.com/episode/63Vj...
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E10 - Momento DeepSeek en Biotech
PÍLDORAS de BIOTECH · Episode
https://open.spotify.com/episode/63VjFkLPu8dclL17FYAXbh?si=og33ZdCHTeSLaa45-qf_GQ
7 months ago
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reposted by
Jordi Xiol
Daphne Zohar
7 months ago
A dark read from a biotech investor. Some important themes here about prioritizing shareholders
substack.com/inbox/post/1...
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How Biotech was broken & how to fix it!
Over the past five years, biotech investors have endured a challenging period, and industry’s struggles are evident.
https://substack.com/inbox/post/159305323?showWelcomeOnShare=false
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"We were badly misled about Covid". TLDR, it's about a potential lab origin. Some serious soul-searching to be done on this topic by the scientific community
www.nytimes.com/2025/03/16/o...
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Opinion | We Were Badly Misled About Covid
The same dangerous mistakes. The same lack of candor.
https://www.nytimes.com/2025/03/16/opinion/covid-pandemic-lab-leak.html
7 months ago
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Roche pays $1.65B upfront to co-develop Zealand Pharma's long-acting amylin agonist for obesity. The deal includes a total consideration of $5.3B and the two companies will split profits evenly in Europe and the US Danish biotech has been on fire lately $ZEAL
www.globenewswire.com/news-release...
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Zealand Pharma and Roche enter collaboration and license agreement to co-develop and co-commercialize petrelintide as a future foundational therapy for people with overweight and obesity
Company announcement – No. 4 / 2025 Zealand Pharma and Roche enter collaboration and license agreement to co-develop and co-commercialize petrelintide as...
https://www.globenewswire.com/news-release/2025/03/12/3041113/0/en/Zealand-Pharma-and-Roche-enter-collaboration-and-license-agreement-to-co-develop-and-co-commercialize-petrelintide-as-a-future-foundational-therapy-for-people-with-overweight-and-o.html
8 months ago
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Now there's talk of a recession and the stock market is crashing. Does anyone still question that the Democrats' problem with the economy is one of communication?
add a skeleton here at some point
8 months ago
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You are not rewriting the genetic code, John Evans, you are rewriting the genetic sequence. The genetic code has been the same since life can call itself life $BEAM
8 months ago
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$MLYS announces positive topline data from two pivotal trials in uncontrolled or resistant hypertension. The primary endpoint was met in both
#portfolio
ir.mineralystx.com/news-events/...
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Mineralys Therapeutics Announces Positive Topline Results from Launch-HTN and Advance-HTN Pivotal Trials of Lorundrostat for the Treatment of Uncontrolled or Resistant Hypertension
– Launch-HTN met its primary endpoint with lorundrostat 50 mg dose achieving a 16.9 mmHg reduction in systolic blood pressure, and a 9.1…...
https://ir.mineralystx.com/news-events/press-releases/detail/60/mineralys-therapeutics-announces-positive-topline-results
8 months ago
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$BEAM positive Ph1/2 data in Alpha-1 Antitrypsin Deficiency, the paradigmatic indication for a base editing approach given that neither a KO nor gene therapy would be sufficient They also priced a $500M offering behind closed doors, this will be controversial
www.globenewswire.com/news-release...
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Beam Therapeutics Announces Positive Initial Data for BEAM-302 in the Phase 1/2 Trial in Alpha-1 Antitrypsin Deficiency (AATD), Demonstrating First Ever Clinical Genetic Correction of a Disease-causin...
Single Dose of BEAM-302 Led to Durable, Dose-dependent Increases in Total and Functional Alpha-1 Antitrypsin (AAT), Production of Corrected M-AAT, and...
https://www.globenewswire.com/news-release/2025/03/10/3039523/0/en/Beam-Therapeutics-Announces-Positive-Initial-Data-for-BEAM-302-in-the-Phase-1-2-Trial-in-Alpha-1-Antitrypsin-Deficiency-AATD-Demonstrating-First-Ever-Clinical-Genetic-Correction-of.html
8 months ago
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reposted by
Jordi Xiol
Simon Bayly
8 months ago
Are the longevity crowd barking up the wrong tree because they have mistaken the chicken for the egg? Evidence that epigenetic 'clocks' are driven by somatic mutations
www.nature.com/articles/s43...
#biosky
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Somatic mutation as an explanation for epigenetic aging - Nature Aging
Koch and colleagues report that epigenetic clocks mirror age predictions based on the accumulation of somatic mutations and show that somatic mutations at CpG sites coincide with extensive remodeling ...
https://www.nature.com/articles/s43587-024-00794-x
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The Monsanto acquisition probably ranks as the worst ever by a pharma company Bayer as a whole is now worth less than what it paid for Monsanto, and litigation is putting the company in financial distress. All karma for not having bought small biotech instead :)
endpts.com/bayer-eyes-c...
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Bayer eyes capital raise as it grapples with Monsanto cases
Bayer is asking shareholders to authorize a potential equity offer that would allow it to quickly raise billions of euros to deal with ongoing Monsanto litigation.
https://endpts.com/bayer-eyes-capital-raise-as-it-grapples-with-monsanto-cases/
8 months ago
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Please no
www.marketwatch.com/story/nasdaq...
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Nasdaq announces plans to launch 24-hour trading Monday through Friday
Nasdaq Inc. on Friday announced the most ambitious plan yet by a major U.S. exchange operator to allow stocks to be traded around the clock.
https://www.marketwatch.com/story/nasdaq-announces-plans-to-launch-24-hour-trading-monday-through-friday-219fbd6a
8 months ago
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CytomX/Amgen discontinue masked EGFR T Cell Engager It seems intuitively hard to get to therapeutic exposures if both sides of the bispecific antibody are masked. More encouraging data with Janux' PSMA bispecific where only CD3 arm is masked $CTMX $AMGN $JANX $VIR
ir.cytomx.com/news-release...
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CytomX Therapeutics Announces 2024 Financial Results and Provides Business Update | CytomX Therapeutics, Inc.
- Continued progress with lead program, CX-2051 (EpCAM PROBODY ® Topo-1 ADC), in Phase 1a study in advanced colorectal cancer with initial Phase 1a clinical data to be presented in 1H 2025 - - CX-801 (PROBODY ® Interferon-alpha 2b) Phase 1a translational data in advanced melanoma expected in 2H
https://ir.cytomx.com/news-releases/news-release-details/cytomx-therapeutics-announces-2024-financial-results-and
8 months ago
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Giving GPT 4.5 a try and the reasoning capacity is getting scary. Where did the people who said that LLMs were just statistical parrots go?
8 months ago
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Dry powder for European biotech: Sofinnova Partners raises €1.2B to fuel the next wave of life sciences innovation
sofinnovapartners.com/news/sofinno...
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Sofinnova Partners raises €1.2 billion to fuel the next wave of life sciences innovation — Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm in life sciences, specializing in healthcare and sustainability. Based in Paris, London and Milan, the firm brings together a team of prof...
https://sofinnovapartners.com/news/sofinnova-partners-raises-eur1-2-billion-to-fuel-the-next-wave-of-life-sciences-innovation
8 months ago
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"Coalition of the willing" is the new way Europe needs to operate on everything, not just geopolitics. Just get together the countries who agree on something, and get it done
www.theguardian.com/world/2025/m...
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Orbán problem pushes EU towards ‘coalitions of the willing’ on Ukraine
As crisis talks loom, Trump and the bloc’s own populist spoilers have driven it away from its old quest for unanimity
https://www.theguardian.com/world/2025/mar/02/orban-problem-pushes-eu-towards-coalitions-of-the-willing-on-ukraine-russia
8 months ago
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Are European labs seeing an uptick in high-quality postdoc applications? Just curious
8 months ago
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Stem cell therapy in epilepsy: an interview with Jonathon Parker, investigator in Neurona Therapeutic’s pioneering trial
#portfolio
www.neurologylive.com/view/stem-ce...
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Stem Cells in Epilepsy: Innovations and Challenges in Neurosurgical Treatment
Jonathon Parker, MD, PhD, an assistant professor of neurosurgery and neuroscience at Mayo Clinic Arizona, provided commentary on the promise and roadblocks behind stem cell approaches in epilepsy.
https://www.neurologylive.com/view/stem-cells-in-epilepsy-innovations-challenges-in-neurosurgical-treatment
8 months ago
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Are low-resolution images in a corporate deck a red flag? yes/no
8 months ago
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John Stewart slices his hand while talking drug pricing The biopharma sector needs to fight the common misconception that drug development is funded by taxpayer money. Basic research and development are both equally necessary, but they're very different things
www.dailykos.com/stories/2025...
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Jon Stewart’s DOGE rage draws blood—literally
“Daily Show” host Jon Stewart accidentally sliced his hand during his opening monologue on Monday night. The incident happened as Stewart worked himself up over the horse manure being tossed ...
https://www.dailykos.com/stories/2025/2/25/2306151/-Jon-Stewart-s-DOGE-rage-draws-blood-literally
8 months ago
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reposted by
Jordi Xiol
Craig M. Crews
8 months ago
First RIPTAC dosed in humans!
#RIPTACs
#prostatecancer
haldatx.com/halda-therap...
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Halda Therapeutics Announces First Patient Dosed in Phase 1/2 Clinical Trial Evaluating HLD-0915 in Metastatic Castration-Resistant Prostate Cancer - Halda Therapeutics
First-in-human clinical trial to evaluate safety and tolerability of a new class of small molecule medicines for the treatment of cancer, RIPTAC™ therapeutics NEW HAVEN, CT, February 24, 2025 – Halda ...
https://haldatx.com/halda-therapeutics-announces-first-patient-dosed-in-phase-1-2-clinical-trial-evaluating-hld-0915-in-metastatic-castration-resistant-prostate-cancer/
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Jordi Xiol
Ysios Capital Partners
8 months ago
#PortfolioNews
| Our
#portfolio
company Neurona Therapeutics plans Phase3 trial in H2 2025 for NRTX-1001, a
#celltherapy
for drug-resistant
#epilepsy
. 🔬 Encouraging early data: Up to 97% seizure reduction with no cognitive impairment 📢 Read more:
https://buff.ly/3Dh9kfv
#VC
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An overwhelming majority are listed in the US. The time is right for Europe to move towards a common listing
8 months ago
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This is certainly not the first time big pharma finds fraudulent data after they acquire a drug from a biotech company. But it may be one of the first times where they openly admit it Novo Nordisk alleges fraud after $1.3B deal to buy drug from KBP Biosciences
www.reuters.com/business/hea...
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Novo Nordisk alleges fraud after $1.3 billion deal to buy hypertension drug from KBP Biosciences
Novo Nordisk is seeking up to $830 million in damages from KBP Biosciences, according to a ruling by a Singapore court, as the Danish drugmaker says it was misled when it bought a new hypertension drug from KBP in 2023.
https://www.reuters.com/business/healthcare-pharmaceuticals/novo-nordisk-alleges-fraud-after-13-billion-deal-buy-hypertension-drug-kbp-2025-02-18/
8 months ago
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reposted by
Jordi Xiol
@RNAiAnalyst
8 months ago
Why I Am taking My HAE Cure Idea to My Grave:
rnaitherapeutics.blogspot.com/2025/02/why-...
$NTLA $BCRX
#HAE
$KALV $PHVS I may have to change to a different platform, blogger/blogspot is becoming shockingly outdated.
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Why I Am Taking a HAE Cure Idea to My Grave
Last year, as I was researching the hereditary angioedema (HAE) therapeutics landscape, I came across data in the C1 inhibitor gene regulati...
https://rnaitherapeutics.blogspot.com/2025/02/why-i-am-taking-hae-cure-idea-to-my.html
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$AZN key 2025 catalysts. AVANZAR trial (Dato-Dxd + durvalumab + chemo) in first-line lung cancer one to watch The combo of ADC + checkpoint inhibitor worked remarkably well in bladder cancer, will this become a broader concept in oncology treatment?
9 months ago
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reposted by
Jordi Xiol
Ysios Capital Partners
9 months ago
🎙️Nueva entrega de nuestro
#Podcast
! PÍLDORAS DE BIOTECH💊 🎯 𝗝.𝗣. 𝗠𝗼𝗿𝗴𝗮𝗻 𝗛𝗲𝗮𝗹𝘁𝗵𝗰𝗮𝗿𝗲 𝗖𝗼𝗻𝗳𝗲𝗿𝗲𝗻𝗰𝗲 📈 Descubre los acuerdos,
#tendencias
y
#retos
que marcarán el 2025 en
#pharma
y
#biotech
. ▶️
https://buff.ly/3Q5lgnn
#YsiosPodcast
#BiotechPillsWithJordi
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$NVS cardiovascular franchise showing its muscle: Both Entresto and Leqvio were characterized as very poor launches, now they are both major growth drivers
www.novartis.com/sites/novart...
9 months ago
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reposted by
Jordi Xiol
Ysios Capital Partners
9 months ago
#entrevista
I🔬#TelescopeBiotechFund , una apuesta estratégica por la
#biotecnología
cotizada. Descúbrelo con
@jordixiol.bsky.social
, Partner en
@ysioscapital.bsky.social
y Horacio Encabo de Andbank en
@capitalradiob.bsky.social
▶️
https://buff.ly/3CkLQG7
#FondosDeInversión
#MercadoFinanciero
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Telescope Biotech Fund: Una apuesta por la innovación biotecnológica
Ysios Capital y Andbank Wealth Management se alían para lanzar un fondo especializado en biotecnología cotizada, Telescope Biotech Fund
https://buff.ly/3CkLQG7
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When Warp Drive Bio first launched I remember thinking those people were insane. Never going to work. Now I’m blown away by every piece of new data with $RVMD’s tri-complex inhibitors. The zeal of the convert
9 months ago
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Efficacy of pan-RAS and KRAS G12D inhibitors from $RVMD in 2L PDAC: 36% and 30% ORR for daraxonrasib and zoldonrasib, respectively
#ASCOGI
9 months ago
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Good amycretin data. It looks like it will be able to break the 25% weight loss psychological barrier. The one cagrisema missed and sent Novo down 30%
add a skeleton here at some point
9 months ago
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One more ADC deal with China: Arrivent licenses ADC from Lepu Biopharma for the treatment of colorectal, pancreatic and other GI cancers. Target undisclosed, $47M in near-term payments $AVBP
ir.arrivent.com/news-release...
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https://ir.arrivent.com/news-releases/news-release-details/arrivent-biopharma-enters-exclusive-license-lepu-biopharma
9 months ago
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Scientist at a not-to-be-named Nasdaq cell therapy company: "I don't know if we're stupid or visionary"
9 months ago
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De novo protein design is the low-hanging fruit of AI for drug discovery
www.nature.com/articles/s41...
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De novo designed proteins neutralize lethal snake venom toxins - Nature
Deep learning methods have been used to design proteins that can neutralize the effects of three-finger toxins found in snake venom, which could lead to the development of safer and more accessible an...
https://www.nature.com/articles/s41586-024-08393-x
9 months ago
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$RLAY is going after the same target than Scorpion and has treated many more patients Why is $RLAY trading under cash while Scorpion is getting acquired for up to $2.5B? The value of showing single-agent activity in oncology
9 months ago
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$GILD paying $250M upfront for LEO Pharma’s preclinical STAT6 portfolio. Talk about a hot target
#JPM25
www.businesswire.com/news/home/20...
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Gilead and LEO Pharma Enter Into Strategic Partnership to Accelerate Development of Oral STAT6 Program With Potential in Multiple Inflammatory Diseases
Gilead Sciences, Inc. (Nasdaq: GILD) and LEO Pharma today announced a strategic partnership to accelerate the development and commercialization of LEO
https://www.businesswire.com/news/home/20250111983856/en/Gilead-and-LEO-Pharma-Enter-Into-Strategic-Partnership-to-Accelerate-Development-of-Oral-STAT6-Program-With-Potential-in-Multiple-Inflammatory-Diseases
10 months ago
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100 years of quantum mechanics. It remains the most fundamental model for how the universe works, but it still cannot explain gravity, space and time
www.nature.com/articles/d41...
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Quantum mechanics 100 years on: an unfinished revolution
A century ago, physics had its Darwinian moment — a change in perspective that was as consequential for the physical sciences as the theory of evolution by natural selection was for biology.
https://www.nature.com/articles/d41586-025-00014-5?WT.ec_id=NATURE-20250109&utm_source=nature_etoc&utm_medium=email&utm_campaign=20250109&sap-outbound-id=F21C14193574A33AC812221371ECDDF718B13DAE
10 months ago
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Jordi Xiol
David Ho
11 months ago
The world’s 280 million electric bikes and mopeds are cutting demand for oil 4x more than electric cars due to their staggering uptake in China and elsewhere.
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The world’s 280 million electric bikes and mopeds are cutting demand for oil far more than electric cars
Electric vehicles get all the press – but it’s the smaller unsung two wheelers cutting oil demand the most.
https://theconversation.com/the-worlds-280-million-electric-bikes-and-mopeds-are-cutting-demand-for-oil-far-more-than-electric-cars-213870
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Jordi Xiol
Natasha Loder
10 months ago
One of my contacts has a theory on why the JPM meeting in San Fran is so conducive to deal making: Jetlag + cocktails.
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Amivantamab + lazertinib showed survival benefit over osimertinib in 1L NSCLC with classical EGFR mutations
www.targetedonc.com/view/amivant...
Meanwhile sunvozertinib, an amivantamab contender in exon20 EGFR-mutated NSCLC, was granted priority review by the FDA
www.onclive.com/view/sunvoze...
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https://www.targetedonc.com/view/amivant..
10 months ago
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X is being used as a political weapon against a democratically elected government in the UK. You all really need to stop posting over there
add a skeleton here at some point
10 months ago
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Some me-toos and some long shots, but two stand out: - $NVS $IONS Pelacarsen cardiovascular outcomes trial. Lp(a) has been associated with CV disease since the 1970s. First of a highly anticipated class of medicines - MORF-057 Ph2b in UC. Is $LLY on a roll also in BD and can orals replace biologics
add a skeleton here at some point
10 months ago
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reposted by
Jordi Xiol
Ted Price
10 months ago
A pretty good year for drug approvals in 2024
www.nature.com/articles/d41...
but neurology lags behind recent trends for the year. Top of the list on what to look forward to in 2025 is Suzetrigine (VX-548) for acute (post surgical) pain in Jan!
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2024 FDA approvals
The FDA approved 50 new therapeutics in 2024, with green lights for a novel schizophrenia drug, a first NASH medicine and much more.
https://www.nature.com/articles/d41573-025-00001-5
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reposted by
Jordi Xiol
Malgorzata Rogalska
10 months ago
What a way to start 2025! Our spliceosome blueprint has been recognized by
@forbes.com
as one of the “Top Five Breakthroughs of 2024”. Huge thanks to my colleagues and my mentor Juan Valcarcel at
@crg.eu
#Biotech
#Spliceosome
#RNA
#Innovation
www.forbes.com/sites/alexkn...
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Five Breakthroughs In 2024 That Laid A Foundation For Future Tech
From transforming coal to computing with DNA to pharmaceutical manufacturing in space, these are the discoveries that will set the stage for the next decade’s technology.
https://www.forbes.com/sites/alexknapp/2024/12/27/top-breakthroughs-of-2024/
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The founder of Christianity, a distinct religion from Judaism centered around the divinity of Jesus, was Paul the Apostle, not Jesus himself. Hyam Maccoby is the author that best encapsulates this notion
10 months ago
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