Rebecca Shapiro
@shapirorebecca.bsky.social
π€ 1096
π₯ 272
π 10
Associate Prof @ U Guelph. Fungal genetics and functional genomics (she/her)
pinned post!
It's been a long time coming to finally see this in print! While not the first paper from my lab, it is one of the very first projects we started working on from day 1
links.springernature.com/f/a/1IP7gCfA...
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Pooled CRISPRi screening reveals fungal-specific drug target candidates - Nature Microbiology
This study presents a pooled CRISPRi screening approach in Candida albicans to investigate essential genes at scale, revealing environment- and strain-dependent gene sensitivities and conserved vulner...
https://links.springernature.com/f/a/1IP7gCfAK_4IvrBY6WGd-A~~/AABE5hA~/sDloX8m24Rtgm_hufqkkRfVugnI34K3sy7oh2G9IuewMYtUYxNWcLeRmgd4AG02LecFE-2w9xs8qLhmuasqUxHLkPUtg_-Cdf1UV7ALemHxg1OtkgYwkVXObelo-H0uwm1kQPK5EDKvYrYYdHCPFTBk86XP8SZhpy2EHxW60NoucP0OBjxq8lb4X62-W9VGn7pNsQASF89W4jISls6WaKP734B2Zp-lDO5rbLV3x5AFJ2rvLb8DK66KPSIZeEBsnDgVQWVrrphGQFNkzRMAIO8ms4BtHUadiGaHHzVKYqZQ~
about 2 months ago
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Rebecca Shapiro
University of Guelph News
about 1 month ago
Resistance to antifungal medications is growing. Now,
#UofG
researchers have developed a faster way to identify the genetic vulnerabilities of Candida fungi, which could lead to brand new treatments.
@uofgcbs.bsky.social
@uofgresearch.bsky.social
uoguel.ph/vze5i
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Faster Gene Screening Method Targets Deadly Fungus
U of G researchers are using CRISPR interference to spot genetic vulnerabilities in Candida albicans, a leading cause of life-threatening infections.
https://uoguel.ph/vze5i
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Rebecca Shapiro
Teresa O'Meara
about 2 months ago
New preprint alert!
www.biorxiv.org/content/10.6...
from my lab and Evan Snitkin's lab Defining the Candidozyma auris pan-genome and essentiality
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https://www.biorxiv.org/content/10.64898/2026.05.12.724661v1
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Rebecca Shapiro
Team Thomma
about 2 months ago
π£ New preprint on
@biorxivpreprint.bsky.social
: Bacteria rewire fungal antimicrobial gene expression in microbial arms races
www.biorxiv.org/cgi/content/...
This work, led by outstanding
@jinyi-zhu.bsky.social
, shows that bacteria suppress fungal antimicrobial protein expression to evade antagonism
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https://www.biorxiv.org/cgi/content/short/2026.05.07.723608v1
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Rebecca Shapiro
Nature Microbiology
about 2 months ago
Out Now! Pooled CRISPRi screening reveals fungal-specific drug target candidates
#MicroSky
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Pooled CRISPRi screening reveals fungal-specific drug target candidates
Nature Microbiology, Published online: 11 May 2026; doi:10.1038/s41564-026-02356-wThis study presents a pooled CRISPRi screening approach in Candida albicans to investigate essential genes at scale, revealing environment- and strain-dependent gene sensitivities and conserved vulnerabilities relevant to antifungal drug discovery.
https://go.nature.com/48TTqEA
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It's been a long time coming to finally see this in print! While not the first paper from my lab, it is one of the very first projects we started working on from day 1
links.springernature.com/f/a/1IP7gCfA...
loading . . .
Pooled CRISPRi screening reveals fungal-specific drug target candidates - Nature Microbiology
This study presents a pooled CRISPRi screening approach in Candida albicans to investigate essential genes at scale, revealing environment- and strain-dependent gene sensitivities and conserved vulner...
https://links.springernature.com/f/a/1IP7gCfAK_4IvrBY6WGd-A~~/AABE5hA~/sDloX8m24Rtgm_hufqkkRfVugnI34K3sy7oh2G9IuewMYtUYxNWcLeRmgd4AG02LecFE-2w9xs8qLhmuasqUxHLkPUtg_-Cdf1UV7ALemHxg1OtkgYwkVXObelo-H0uwm1kQPK5EDKvYrYYdHCPFTBk86XP8SZhpy2EHxW60NoucP0OBjxq8lb4X62-W9VGn7pNsQASF89W4jISls6WaKP734B2Zp-lDO5rbLV3x5AFJ2rvLb8DK66KPSIZeEBsnDgVQWVrrphGQFNkzRMAIO8ms4BtHUadiGaHHzVKYqZQ~
about 2 months ago
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reposted by
Rebecca Shapiro
Linda Horianopoulos
2 months ago
It's Mycology Monday! π Which reminds me! CanFunNet registration is now open:
canfunnet.conferences.uwo.ca/registration
If you study fungi, this broad fungal conference is a great one to attend (or present at).
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Rebecca Shapiro
College of Biological Science
2 months ago
Antifungal resistance isnβt just about one gene.𧬠Researchers led by PhD student Nick Gervais &
@shapirorebecca.bsky.social
have developed a new CRISPR tool that can control multiple genes at once in fungal pathogens. SCRIBEποΈ:
www.uoguelph.ca/cbs/news/202...
@uofgresearch.bsky.social
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reposted by
Rebecca Shapiro
Ira Blader
3 months ago
PIs/group leaders, what was the most important aspect of the first paper your lab published 1οΈβ£
Establishing the lab's identity
2οΈβ£
Communicating an important discovery
3οΈβ£
Completing a project started as a postdoc
4οΈβ£
Other
π Show results
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reposted by
Rebecca Shapiro
Ontario Genomics
about 1 year ago
Today is the last day to register for SynBio7.0! Will we see you there?
add a skeleton here at some point
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reposted by
Rebecca Shapiro
SynBio7.0
about 1 year ago
Today is the last day to register for SynBio7.0 in Toronto!
www.eventbrite.ca/e/synbio-70-...
The phenomenal lineup of speakers is now available on the website (
synbio7.vercel.app#schedule
). I hope you can join us!
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reposted by
Rebecca Shapiro
Flow Genomics π¨π¦
about 1 year ago
We're looking forward to attending the upcoming SynBio7.0 conference in Toronto!
add a skeleton here at some point
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Join us for SynBio7.0 in Toronto!
add a skeleton here at some point
about 1 year ago
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