New research @eClinicalMed - A large-scale comparison of clinical outcomes to IBD therapies in White and South Asian ethnicities www.thelancet.com/journals/ecl... #GastroSky #MedSky #IBDSky

Great to see out this study from Sharmili Balarajah and Laura Martinez-Gili @imperialmdr.bsky.social, working with the #IBD @nihrbioresource.bsky.social, comparing outcomes with #IBD therapies in White and South Asian patients, now in @eclinicalmed.bsky.social: www.sciencedirect.com/science/arti...

Very pleased to see this practical guide to #nutrition in #cirrhosis out in #FrontlineGastroenterology: fg.bmj.com/content/earl.... Thanks to Luke Tyson for leading the group! #liversky

Honoured to speak on #FMT #LBPs at the #EHMSG meeting today in session with Nicolas Benech and Jens Walter. Thanks to Gianluca Ianiro for organising, and for even getting a @nobelprize.bsky.social winner for Physics to speak to us, Giorgio Parisi! @imperialmdr.bsky.social #microbiomeclinicians

www.sciencedirect.com/science/arti... - we used an AMS approach to operationalise & formalise a structured approach to FMT @imperialcollegeldn.bsky.social @imperialnhs.bsky.social

Out now from us in @thejhi.bsky.social - operational considerations in running an #NHS #FMT service: www.sciencedirect.com/science/arti... @imperialmdr.bsky.social @imperialbrc.bsky.social #GastroSky #MicroSky #IDSky

Very pleased to see this out in @cmijournal.bsky.social - what non-antimicrobial options are there for recurrent #UTI, and what might be the role for #FMT? www.clinicalmicrobiologyandinfection.com/article/S119... @rohmaghani.bsky.social @imperialmdr.bsky.social @imperialbrc.bsky.social #MicroSky

We’ve also written a Behind the Paper blog post to accompany our article, which you can find here: go.nature.com/401ctsa

Great to see this work from Shiv Radhakrishnan and colleagues out in #GutMicrobes - using network analysis to explore #microbiome #metabolome interactions in an #IBD inception cohort: doi.org/10.1080/1949... @imperialmdr.bsky.social @imperialhepatology.bsky.social #IBDSky #GISky

So excited to share a new paper from my lab just published in Nature Communications! We showed that vancomycin-resistant enterococci (VRE) occupied distinct intestinal niches in the antibiotic-treated intestine. doi.org/10.1038/s414... Amazing work by first author Olivia King and colleagues!

Vancomycin-resistant 𝙀𝙣𝙩𝙚𝙧𝙤𝙘𝙤𝙘𝙘𝙪𝙨 𝙛𝙖𝙚𝙘𝙞𝙪𝙢 (VRE) thrives in the antibiotic-perturbed gut VRE gobbles up enriched sugars and amino acids, and loss of short-chain fatty acids (acetate, propionate, butyrate) eliminates natural growth brakes Therapeutic angle: Prebiotic SCFA mixtures block VRE growth!

A great privilege to work with @julieakmcdonald.bsky.social lab on this new paper, now out in @natureportfolio.nature.com Communications - how #antibiotic-related changes in gut #nutrients and #metabolites promote #VRE colonisation: doi.org/10.1038/s414... @imperialmdr.bsky.social

Honoured to to be part of this Future of Hepatology session at @easlnews.bsky.social #EASL2025, discussing the promise of #microbiome related therapies in #PSC #cholestatic liver disease - where have we come since the original #FMT #PSC pilot study by @DrAllegrettiIBD? doi.org/10.14309/ajg...

Delighted to welcome Manchester Royal Infirmary onto the #MAST trial as our seventh site! Pleased to be able to expand our coverage for this important trial of #GutMicrobiome manipulation with #IMT #FMT before #HCT; find out more here: www.imperial.ac.uk/metabolism-d... @imperialmdr.bsky.social

Want to know more about why we are looking at the #GutMicrobiome #IMT #HCT as therapy? Find out even more here: youtu.be/zDd1qdVCa6A?...

The #MAST trial is pushing forward, investigating the impact of #IMT #FMT prior to #HCT in seven UK centres #HaemSky #MicrobiomeSky #GastroSky @imperialmdr.bsky.social @bloodcanceruk.bsky.social ruk.bsky.social @anthonynolan.bsky.social. Find out more from our poster or our website: rb.gy/myizsb

The relationships between MASLD, extrahepatic multimorbidity and all-cause mortality in UK Biobank cohort https://www.medrxiv.org/content/10.1101/2025.03.09.25323328v1

A great first day at the #BSG #GutMicrobiome event, covering everything from early life @halllab.bsky.social, to #liver @debbieshawcross.bsky.social, to #cancer @jameskinross.bsky.social, and culminating in a tour de force on #IBD and the #microbiome in clinical practice from Prof Harry Sokol

MAST is moving onwards and upwards and now up to 18 recruited patients. We push on, hoping to see how gut #microbiome manipulation with #IMT #FMT can help our patients with #BloodCancer #HCT @bloodcanceruk.bsky.social @anthonynolan.bsky.social

Pleased that #FARGO - a randomised, multicentre, placebo-controlled phase IIa trial of #FMT to treat #PSC - is running and recruiting. Have a look at the protocol paper out now in #BMJOpen: doi.org/10.1136/bmjo... @pscsupport.bsky.social @cholestasisdoc.bsky.social

Great that the #MAST trial is moving ahead, and really hoping that this shows the #microbiome as a route to give new treatment prospects to #HCT #BloodCancer patients @bloodcanceruk.bsky.social @cancerresearchuk.org

Great work by Nabil Quraishi, Palak Trivedi and many others - unravelling the positive impact of #vancomycin in #PSC #IBD by altering interactions between the host, #microbiome, and #metabolome. Now in #JCC: academic.oup.com/ecco-jcc/adv... #GastroSky

Great to work with the lab of @julieakmcdonald.bsky.social and see this preprint out on @biorxivpreprint.bsky.social, looking at how nutrient availability and microbial #metabolites impact #VRE colonisation in the #antibiotic treated gut: www.biorxiv.org/content/10.1... #MicroSky #GastroSky

Great work by Sharmili Balarajah with #ImperialMDR colleagues and the @nihr.bsky.social #IBD Bioresource team, now in press in #JCC - exploring differences in #IBD phenotypes and treatment approaches between White and South Asian patients in the UK: academic.oup.com/ecco-jcc/adv...

Thanks to Gianluca Ianiro for co-ordinating the international consensus statement on #microbiome testing in clinical practice, now in Lancet GastroHep - an assessment of where we are and where we hope to go: doi.org/10.1016/S246... #GastroSky #MedSky

Unstoppable in the name of #AMR, even if it means being poisoned by The Thames - #microbiome manipulator extraordinaire, Prof Julian Marchesi @gut-health.bsky.social

We are pleased that the #MAST study is live on @bsky.app! Read here 👇 about this trial of modulating the #GutMicrobiome using #IMT #FMT prior to #HCT for #BloodCancer 🩸🦠: www.imperial.ac.uk/metabolism-d... #MRC #EnteroBiotix @anthonynolan.bsky.social @bloodcanceruk.bsky.social

An extraordinary read of incredible braveness in a horrific situation in this week’s #NEJM: www.nejm.org/doi/full/10....

Great to have our new review out - what we do and don't know about how clinical, biological and procedural considerations impact the efficacy of #IMT #FMT in repairing the #GutMicrobiome: www.tandfonline.com/doi/full/10.... … a great team effort