Great thread by @claudiocantu81.bsky.social! We wondered how 2 adjacent cell types in the intestinal crypt that depend on #WNT / β-catenin, Stem cells and Paneth cells, turn on very different expression programs in response to #WNT. We find that GATA factors drive #WNT dependent lineage choices.

Join 🇸🇪 🌞 The PALS Summer School in TranscriptOMICS 🧬 🧪 To learn about ➡️ Dynamics of immunological tissue architecture in the human gut ⬅️ by ⭐ professor Simon Koplev ⭐ from KTH @scilifelab.se @kawresearch.bsky.social @remeseiro-lab.bsky.social REGISTER NOW! www.trippus.net/summerschool...

We're hiring! The vacancy for a PhD student position in our lab, working on a KWF-funded project "Targeting WNT/CTNNB1 signaling in breast cancer" is now open. Check it out (or forward it) if you are (or know) someone who might be interested and a good fit: werkenbij.uva.nl/en/vacancies...

Fresh pre-print: our all-human, innervated & vascularized oral cancer-on-chip, all done with fully defined extracellular matrices with controlled enrichment and degradability! 🔥 www.biorxiv.org/content/10.6...

Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample? Yes, one can. with CUT&ID ✂️🪪 Spearheaded — singlehandedly — by @annanordin.bsky.social No need of transgenesis, cloning and overexpression. Check it out, it's fast and its works.

Save the date 23-26 June 2026 The Third Edition of The PALS Summer School in OMICS is on! Soon registration+other info If you are interested to teach (if you are a former participant) please get in touch with me or @remeseiro-lab.bsky.social 🙏 @scilifelab.se @kawresearch.bsky.social

In one tumor, despite the shared oncogenic driver mutations, there may be different cell types In collaboration with the Peng Lab we used Hepatoblastoma to investigate this. Our results show that β-catenin can drive different transcriptional programs across cancer cell populations Check this out👇

We are hiring! 2 years postdoctoral fellowship, to work on the generation of all-human, vascularized and innervated organ-on-chip systems & model infection & inflammation - in Sweden 🇸🇪 @liu.se Details in the link - please help me spreading the announcement! liu.se/en/organisat...

SOX2 and NR2F1 cooperate to make #neurons in the #Thalamus for visual input from the #retina #DevBio journals.biologists.com/bio/article/... ‪ @biologyopen.bsky.social In collab w Sara Mercurio and Silvia Nicolis @btbsunimib.bsky.social Driven by Linda Serra and @annanordin.bsky.social

A 6-year long study from the Lab is finally out @genomeresearch.bsky.social Mastered by @annanordin.bsky.social in collaboration with Chaitali Chakraborty from @remeseiro-lab.bsky.social Why is our work Important? Discover it in the quick Bluetorial 👇 genome.cshlp.org/content/earl...

A study led by @claudiocantu81.bsky.social show how the protein TBX3, key in early development, resurfaces in aggressive cancers – making them harder to treat. New insights, new hope for targeted therapies. 🔗 liu.se/en/news-item... #research #cancer

We had previously shown that TBX3 and #WNT cooperate in limb #DevBio We now have a shocking finding, just published in @pnas.org TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC) www.pnas.org/doi/epub/10....

Story time! We are excited to share our new Biorxiv pre-print which we hope will also find a home in a peer-reviewed journal soon: "GRHL and PGR control WNT4 expression in the mammary gland via 3D looping of conserved and species-specific enhancers" www.biorxiv.org/content/10.1...