Thrilled to share our latest preprint describing an optimized spatial tissue proteomics workflow for the preparation and analysis of >100 proteomes / day at high spatial resolution. Kudos to @melissaklingeberg.bsky.social 🥳 and big thanks to all our collaborators! bit.ly/3SCARw4

Excited to introduce openDVP — an open-source framework to bring deep visual proteomics to the broader research community! It includes: – A simplified fast-track pipeline for easy adoption – An AI-powered option for advanced image & spatial analysis 👉 BioRxiv: bit.ly/44SBuHu 👉 Github: bit.ly/4eR3IqK

www.cell.com/cell-systems... CosMx data by @brukerspatial.bsky.social Second harmonics by Andrew Woehler Immunofluorescence by @sonjafritzsche.bsky.social and @josenimo.bsky.social in Fabian Coscia lab STIM for 3D alignment by @preibischs.bsky.social @nukappa.bsky.social et al (coming very soon!)

Our lab's newest preprint is out on deep spatial proteomics of ovarian cancer precursor lesions! We demonstrate how ultrasensitive discovery proteomics can shed light onto early carcinogenesis, uncover cell-of-origin signatures, and prioritize novel drug targets. bit.ly/41M7fke