We’re happy to share our new preprint form @N_Rajewsky, with @tmpentimalli.bsky.social i.bsky.social @Ilan Theurillat lab! 🎉 🧬 Spatiotemporal atlas of tumor–stroma crosstalk in a new TNBC model. Spatial transcriptomics (Open-ST), snRNA-seq, and functional validation. 🔗 biorxiv.org/content/10.1...

Our 3D study of the tumor microenvironment is finally out! Play around with the data yourself at lung-3d-browser.mdc-berlin.de (Kudos to @danilexn.bsky.social👏 ) Many thanks to Nikolaus Rajewsky lab at @mdc-bimsb.bsky.social and everyone involved, it takes a village to raise a multimodal paper!

🧬 Want to implement Open-ST in your lab? We've published a detailed guide that takes you from tissue sections to 3D molecular maps star-protocols.cell.com/protocols/3922

#SpatialTranscriptomics is revolutionizing gene expression profiling at subcellular resolution! 🔬These 'molecular microscopes' can unlock disease mechanisms & guide therapies... But how to bring ST to the clinic? Our thoughts with T. Pentimalli and N. Rajewsky out @annualreviews.bsky.social 🧵👇