Pomelo on tatami as the cover of RIKEN Research www.riken.jp/medialibrary...

Plant Science Research Weekly -- Discovery and engineering of synthetic RLKs (Science) @shirasulab.bsky.social @brunongou.bsky.social @yasukadota.bsky.social @BrunoNgou (Summary by Mary Williams @PlantTeaching.bsky.social) buff.ly/JlJKjJE #PlantaePSRW

Well done, Max! Neofunctionalized RGF pathways drive haustorial organogenesis in parasitic plants | Science Advances www.science.org/doi/10.1126/...

this research is potentially also interesting to botanical industries (herbalist, food, cosmetics, cannabis, etc.) and maybe even to pharma, because a lot of the botanically derived extracts those industries use come from plant immune systems and their structure and function against pathogens.

Discovery and engineering of synthetic RLKs plantae.org/discovery-an...

BIK1-RIN4 complex links plant immunity and pathogen virulence www.biorxiv.org/content/10.1...

理研、植物が病原体からの「危険サイン」を検知するセンサーの役割を持つ免疫受容体をさまざまな種から探索する方法を開発 - 日本経済新聞 www.nikkei.com/article/DGXZ...

Game-changing biotech for engineering pathogen-resistant crops | EurekAlert! www.eurekalert.org/news-release...

病原体を見分ける植物のセンサーをデザイン | 理化学研究所 www.riken.jp/press/2025/2...

Excited to announce that our latest paper has just been published in Science! ttps://www.science.org/doi/10.1126/science.adx2508

Very happy to share our latest work “Systematic discovery and engineering of synthetic immune receptors in plants” out in @science.org ! www.science.org/doi/10.1126/...

With this approach, we aim to characterize more PRRs against different pathogens & pests in the future.

I am very grateful to Michele & Marc, Takehiro & Dohmae-san, Markus, @yasukadota.bsky.social & @shirasulab.bsky.social for their support. Also big thanks to the reviewers and editors for improving our manuscript!

Registrations are rolling in for the 2025 Stromlo Plant Pathology meeting in Canberra (Nov 27–28)! Secure your spot! Speakers: @yasukadota.bsky.social, Cecille Segonzac, @thamlab.bsky.social, @yichangsung.bsky.social, Tek Tay & @danielsyu.bsky.social. Register at tinyurl.com/3e3tx9j2 #strompath25

🌱 From Nature Plants: Phosphorylation of NLR immune receptors by a cell wall–associated kinase limits resistosome assembly, fine-tuning plant immune responses. (Savithramma P. Dinesh-Kumar) ▶️ www.nature.com/articles/s41... #PlantBiology #PlantScience

Our new work uncovering how WIND1 promotes somatic embryogenesis as a bifunctional chromatic regulator!!!! We knew WIND1 promotes new fate acquisition and now we show WIND1 also helps repressing existing identity!

WIND1 controls cell fate transition through histone acetylation and deacetylation during somatic embryogenesis https://www.biorxiv.org/content/10.1101/2025.08.07.669221v1

A truly enabling new approach by @taralowensohn.bsky.social Will Cody and @sattelylab.bsky.social to probe plant genetics at scale. Single-gene-per-cell delivery coupled to an effective transcriptional selection system www.biorxiv.org/content/10.1...

Chitin Soil Amendment Triggers Systemic Plant Disease Resistance Through Enhanced Pattern‐Triggered Immunity - Makechemu - Plant Biotechnology Journal - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...

Exciting preprint! CryoEM structure of plant ROS & quinone receptor CARD1 (also known as HPCA1) reveals it is a copper dependent redox sensor (and cys residues not essential). CARD1 is a member of LRR-RLK clade VIII-1. www.biorxiv.org/content/10.1...

植物が寄生線虫や昆虫を認識するメカニズムを解明しました！ 植物は“危険サイン”により寄生線虫を察知する www.riken.jp/press/2025/2...

🎉 Our new paper is out in Science Advances! Plants can detect parasitic nematodes. www.science.org/doi/full/10....

Here comes the final version. Congratulations Erika, Yasu, Ken, and all others involved! @yasukadota.bsky.social @shirasulab.bsky.social www.science.org/doi/10.1126/...

Excited this paper is finally published! We focused on the inner concave surface of LRR RKs to expand bacterial flagellin perception in plants. Selection indicates expanded perception is more common than previously thought. Experiments led by @jerrytli.bsky.social www.nature.com/articles/s41...

Cryo structure of CARD1 from N. benthamiana transiently produced protein.

Our new work lead by Anuphon. Cryo Structure of CARD1 reveals copper in the ecodomain, required for sensing H202. The phenotype of card1 is same as rbohd, suggesting ROS produced by RBOHD is sensed by CARD1.

BTW, he is not my PhD student.

I'm very happy that this paper is now published in PNAS! Isochorismate-based salicylic acid biosynthesis appears to have emerged in the Brassicales after the divergence of C. papaya, likely within the timeframe between the divergence of B. maritima and R. odorata. www.pnas.org/doi/10.1073/...

Songyuan Zhang - what can we learn from natural variation that can inform receptor engineering? Combined observed sequence variation with AlphaFold3 prediction to model and engineer the pattern recognition receptor FLS2, and then the pathogen peptide agonist flg22. #2025ISMPMI

If you are enjoying #2025ISMPMI then you might also be interested in joining the Plant Peptide and Receptor Meeting #PPRM2025, 8th-10th September in Edinburgh. We have a great lineup of speakers and a diverse and inclusive community. More info here pprm2025.events.kdmeventsportal.co.uk

New preprint! 📑@danimstevens.bsky.social led the development of mamp-ml, a machine learning protein language model approach to predict functional outcomes of immune receptor - microbial peptides interactions. mamp-ml performs better than AlphaFold2 I will talk about it Thr 10:10-10:30 #2025ISMPMI

#2025ISMPMI has been great, so many connections made and re-established. I found this on the railway bridge.

The original works: SYR2-SYR1: Zhou et al 2025, Dev Cell www.sciencedirect.com/science/arti... DM3/DM2: Wan et al 2025, Mol Cell www.cell.com/molecular-ce...

Second, work from Eunyoung Chae on autoimmunity mediated by the NLR DM2 and DM3 "Dangerous mix". CryoEM structures show a shift in enzyme hexamer stability to be the allele-specific trigger for DM2. We highlight that Alphafold can't predict this structural shift. www.cell.com/molecular-ce...

We recently wrote two Preview articles of exciting MPMI papers in Mol Cell and Dev Cell. Two surprising cases showing different ways to regulate immune receptors in plants -- the cell surface LRR-RK, SYR1 and the intracellular NLR DM2 Short summaries below 🧵🌱 #2025ISMPMI

Are you interested in receptor kinase signalling and plant immunity? We have several positions open to join our team at @thesainsburylab.bsky.social in Norwich. #plantscience #mpmi #plantimmunity #sceincejobs Please get in touch if you have questions 1/5

Riyohei Thomas Nakano (@luckystrike1984.bsky.social) is presenting new work about the mechanisms of disease suppressive microbes. Have identified AhcY mutant and looking into downstream effects. #2025ISMPMI

Yasuhiro Kadota @yasukadota.bsky.social from RIKEN, also @shirasulab.bsky.social lab colleague, talks about identification of nematode MAMP and its receptor. Many years of hard work sacrificing bunch of C. elegans in single slide. Not this image

Predicting the protein interaction landscape of a free-living bacterium with pooled-AlphaFold3 https://www.biorxiv.org/content/10.1101/2025.07.01.662654v1

This is textbook cell biology material by chin-hang Wu and colleagues . Check it out 👇 #plantsci #plantpath #immunology #NLRbiology www.biorxiv.org/content/10.1...

🌱 Excited to announce the Plant Peptide Receptor Meeting will take place in Edinburgh, 8–10 Sept 2025 #PPRM2025 Focusing on the latest research on plant peptides & receptor kinase signalling. ⏳Early bird registration closes in just 2 weeks! 🔗 pprm2025.events.kdmeventsportal.co.uk#countdown

I like this work! A synthetic jasmonate receptor agonist uncouples the growth–defense trade-off in rice www.pnas.org/doi/abs/10.1...

Thrilled to share our new paper in @science.org describing our discovery that bacteria can switch from competitors to bonafide predators when resources run dry—arming nanoscale “spears” (T6SS) to stab & consume neighbours. www.science.org/doi/10.1126/... #MicroSKy #Microbiology

Latest paper from the lab @eveteyssier.bsky.social @malick-mbengue.bsky.social @melaniekrich.bsky.social @pierremarcdelaux.bsky.social et al. just out @pnas.org : 1) Plants have used LysM-RLK receptors for 450 million years to dialog with symbionts, and 2) CO/LCOs might not be that essential

New alleles of Arabidopsis BIK1 reinforce its predominant role in pattern-triggered immunity and caution interpretations of other reported functions www.biorxiv.org/content/10.1...

Two exciting papers from Shirasu Lab utilizing the *juice* of my favorite biological players—Agrobacterium and nematodes—to investigate receptor profiles! 🦠 www.biorxiv.org/content/10.1... 🪱 www.biorxiv.org/content/10.1... Congrats to the authors! 🥳🤩

Happy to announce that registration for the 2025 Stromlo Plant Pathology (and plant pests!) conference at ANU is now open (Nov 27-28). Plenary speakers confirmed include @yasukadota.bsky.social, Cecile Segonzac [email protected]. Please go to tinyurl.com/2rdxuap3 to register - all are welcome!

Join us for the 🪴 🌵 Plant Peptide Receptor Meeting 2025 ☘️ 🪴 in 🏴󠁧󠁢󠁳󠁣󠁴󠁿 Edinburgh 🏴󠁧󠁢󠁳󠁣󠁴󠁿 8th-10th September #plantsignaling #PlantScience #plantsci pprm2025.events.kdmeventsportal.co.uk @pprm2025.bsky.social A thread 🧵 (1/n)

Rep1 vs. Lep1? …for Japanese speakers nph.onlinelibrary.wiley.com/doi/full/10....