Cameron Dale MacQuarrie
@cdmacquarrie.bsky.social
📤 439
📥 619
📝 56
Scientist at Arcadia Science Berkeley, CA, USA Cell Biology He/Him
New pub from @ArcadiaScience 🧵 We found that C. smithii — a freshwater green alga — undergoes wild morphological transformations when grown on Marine Broth. Huge cells with mysterious wisp-like appendages. Here's what we saw.
thestacks.org/publications...
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Morphological transformation of Chlamydomonas smithii grown in Marine Broth medium
Marine Broth induces extreme morphological transformation in C. smithii: Cells shift from typical ellipsoid shape to amorphous forms with thin wisp-like appendages containing mitochondria, revealing u...
https://thestacks.org/publications/observation-marine-broth-chlamy
3 months ago
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Excited to share some new work from
@arcadiascience.com
at
#CellBio2025
! We’re using Chlamydomonas reinhardtii as a rapid in vivo platform to model ADA1 deficiency and test computationally designed therapeutic ADA1 variants. Poster PDF:
bit.ly/chlamy-ADA
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Chlamydomonas Cellular Phenotypes Enable in vivo Validation of Computationally Designed Therapeutic ADA1 Variants
Poster presented at CellBio 2025 in Philadelphia, PA. December 2025Abstract:Adenosine deaminase (ADA) deficiency causes severe combined immunodeficiency, and current treatments include enzyme replacem...
https://bit.ly/chlamy-ADA
6 months ago
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Discovered some unexpected growth phenotypes in Chlamydomonas flagellar mutants! The cpc1-1 strain (with central pair complex defects) shows surprising metabolic traits that might be independent of its flagellar defects. đź§µ
research.arcadiascience.com/pub/observat...
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Chlamydomonas cpc1-1 mutant exhibits unexpected growth phenotypes
Comparative analysis of <i>Chlamydomonas </i>strains revealed that a <i>cpc1-1</i>Â mutant has three unexpected growth phenotypes across different media types, suggesting possible genetic background co...
https://research.arcadiascience.com/pub/observation-chlamy-cpc1-growth
about 1 year ago
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reposted by
Cameron Dale MacQuarrie
Arcadia Science
over 1 year ago
Happy Darwin Day! Today, we’re thinking about how to use evolution to accelerate biomedical research. We think the answer is to expand the repertoire of organismal models. Search for the best ones using our new portal, Zoogle:
zoogle.arcadiascience.com
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Today at
#CellBio24
, I'll discuss our new pub at the "Quantitative Biology in Emerging Model Systems" subgroup session at 5:15 pm in Ballroom 20A. Come check it out!
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over 1 year ago
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Today at
#CellBio24
, Dave Mets will be at poster B599 talking about mapping genotypes to phenotypes! poster:
zenodo.org/records/1449...
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over 1 year ago
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Our new pub dropped this weekend! For those at
#CellBio24
, I'll be at poster B73 starting at 11:15 am discussing this work! I'll also be giving a talk on Tuesday at 5:15 pm in Ballroom 20A in the Quantitative Biology in Emerging Model Systems session poster here:
zenodo.org/records/14481493
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over 1 year ago
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đź§µ New from
@arcadiascience.bsky.social
: We used Chlamydomonas mutants to model specific types of spermatogenic failure and found drugs can rescue swimming behavior in mutation-specific ways. Full pub:
research.arcadiascience.com/pub/result-chlamy-spgf
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Rescuing Chlamydomonas motility in mutants modeling spermatogenic failure
We used Chlamydomonas reinhardtii motility mutants with disrupted genes homologous to human SPEF2 or DNALI1 to model spermatogenic failure disorders SPGF43 and SPGF83, respectively. We recovered aspec...
https://research.arcadiascience.com/pub/result-chlamy-spgf
over 1 year ago
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Tomorrow at
#CellBio24
, I'll be at poster (B73) talking about some fun new work we just released using Chlamydomonas to model spermatogenic failure. Check out the poster here:
zenodo.org/records/14481493
Join the fun and post your comments & questions on the pub!
bit.ly/chlamy-spgf
add a skeleton here at some point
over 1 year ago
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Happening soon at
#CellBio24
@ascbiology.bsky.social
Ryan York's poster (B574) on a data-driven approach to selecting your model organism
@arcadiascience.bsky.social
Poster here:
zenodo.org/records/14479386
Join the fun & post your comments & questions on the pub!
bit.ly/evolutionary...
add a skeleton here at some point
over 1 year ago
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reposted by
Cameron Dale MacQuarrie
Prachee Avasthi
over 1 year ago
Ryan’s poster:
zenodo.org/doi/10.5281/...
The concept:
research.arcadiascience.com/pub/idea-sel...
The approach and analyses:
research.arcadiascience.com/pub/result-e...
The validation:
research.arcadiascience.com/pub/result-c...
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reposted by
Cameron Dale MacQuarrie
Prachee Avasthi
over 1 year ago
If you’re at
#CellBio2024
drop by Ryan’s poster today (Board B574) to hear the latest from
@arcadiascience.bsky.social
about how you can choose the right model system for your research or find areas best studied in the species you have expertise/infrastructure Poster and publications below
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reposted by
Cameron Dale MacQuarrie
Joseph W. Brown
over 1 year ago
Annual reminder that PhyloPic is your free go-to source for organismal silhouettes for
#Jack-o'-lantern
designs
phylopic.org
@tmkeesey.bsky.social
đź§Ş
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PhyloPic
PhyloPic is an open database of free silhouette images of animals, plants, and other life forms, available for reuse under Creative Commons licenses. Download silhouettes for use in educational materi...
http://phylopic.org
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Two weeks ago we
@arcadiascience.bsky.social
posted our final, major update to our Chlamydomonas sp. phenotypic variation pub!
research.arcadiascience.com/pub/result-c...
! A lot of new findings in the đź§µ!!! 1/9
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Phenotypic differences between interfertile Chlamydomonas species · Genetics: Decoding evolutionary...
We’re crossing C. reinhardtii and C. smithii algae for high-throughput genotype-phenotype mapping. In preparation, we’re comparing the parents to uncover unique species-specific phenotypes.
https://research.arcadiascience.com/pub/result-chlamydomonas-phenotypes
over 2 years ago
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🎉 Excited to share our latest work at
#CellBio23
! I'll be presenting a poster on our pub “Phenotypic differences between interfertile Chlamydomonas species” and our continued work in the Protists and Parasites Cell Biology poster session (Board #723)
@arcadiascience.bsky.social
over 2 years ago
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DALL-E's take on a colored pencil sketch of Chlamydomonas
over 2 years ago
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🚨
@arcadiascience.bsky.social
is hiring an Image Analysis scientist!!! 🔬
jobs.lever.co/arcadiascien...
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Arcadia Science - Scientist, Image Analysis
A Bit About Us: We are Arcadia Science. Arcadia is a science company founded and led by scientists. Our mission is to transform evolutionary innovations into real-world solutions by openly developing ...
https://jobs.lever.co/arcadiascience/14d3bed3-be02-47eb-ac4c-fa730180073f
over 2 years ago
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Are you a Chlamydomonas reinhardtii or Chlamydomonas smithii? Find out here!!!
www.buzzfeed.com/cameronmacqu...
#SpiritAlgae And check out the latest version of our
@arcadiascience.bsky.social
pub comparing the 2 species!
research.arcadiascience.com/pub/result-c...
#ArcadiaGenetics
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Are You Chlamydomonas Reinhardtii Or Chlamydomonas Smithii?
Which microalgal species are you? Read the pub here: https://research.arcadiascience.com/pub/result-chlamydomonas-phenotypes/
https://www.buzzfeed.com/cameronmacquarrie/which-chlamydomonas-species-are-you-g7825nudn4
over 2 years ago
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reposted by
Cameron Dale MacQuarrie
Arcadia Science
almost 3 years ago
🗣️ Calling all microscopy enthusiasts! We're looking for publicly available, open-source video data featuring bright-field, DIC, or phase-contrast images. These data will complement our own in a new study on focus-filtering techniques. Please comment with a link to a public repository!
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New pub update from
@arcadiascience.bsky.social
! ! We've just released an update to our research on the 2D cell morphology of C. reinhardtii and C. smithii, two interfertile algal species.
research.arcadiascience.com/pub/result-c...
almost 3 years ago
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