Armand
@armand.bsky.social
📤 697
📥 313
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positive sum human prox.bio
one of the problems with the new peptide craze is that people unfamiliar with how hard it is to actually understand drug biology treat risk monolithically when it is anything but this tweet inspired by my absolute horror of people injecting pig brain lysates into their body
3 months ago
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one mistake early founders often make is that they think they should be able to accurately assess every single candidate in a recruiting process unfortunately the candidates where you have high s/n is somewhat stochastic, based on your experience so far
11 months ago
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reposted by
Armand
Marco
over 1 year ago
I squeaked over the 2k followers mark on the last day of 2024. Let's see how it goes in 2025!
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love this!
add a skeleton here at some point
over 1 year ago
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reposted by
Armand
Stephan Hacker
over 1 year ago
Since yesterday, I have been able to add:
@kamatsiddhesh.bsky.social
@balynzaro.bsky.social
@armand.bsky.social
(Armand Cognetta)
@xingyuliu9595.bsky.social
@vincorine.bsky.social
(Benjamin Horning)
add a skeleton here at some point
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every now and then i have a good idea. here's how I think about having them: 1/ have lots of ideas you have to train your mind to be an idea engine and the easiest way to do that is to just to start having a lot of them.
over 1 year ago
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one of the hard lessons I've learned about recruiting is that you've gotta be ok with passing on lots of amazing candidates that you think could be rockstars to get to the (much more rare) candidates that you absolutely *know* are
over 1 year ago
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relatedly have friend who thinks it’s super important to have hobbies that require the use of two hands. so you can’t causally doom scroll while doing them
add a skeleton here at some point
over 1 year ago
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*reopens bsky after a year* *people publicly advocating for murder on the tl* *homer.gif*
add a skeleton here at some point
over 1 year ago
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macrocycles are the catnip of the medicinal chemistry world
over 1 year ago
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My framework for effective ideation
https://writing.arman.do/p/how-to-have-ideas
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How to have ideas
On occasion I’ve been blessed to have good ideas flow through me. While there’s probably an element of luck in this, I also believe this is a deeply learnable skill, and one that many people negle...
https://writing.arman.do/p/how-to-have-ideas
almost 3 years ago
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🏃🏻♂️
almost 3 years ago
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Blood donation and blood donor mortality after adjustment for a healthy donor effect 👀🧪
almost 3 years ago
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Who are the bio/chem bio/biotech peeps on bsky I should follow? 🤓
almost 3 years ago
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just hit inbox zero for the first time since starting my co, what is this magical feeling 😇
almost 3 years ago
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receiving books is my love language
almost 3 years ago
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bsky is the greatest social network ever created 🙇🏻
add a skeleton here at some point
almost 3 years ago
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one of my all-time fav
@neilhimself.neilgaiman.com
memories
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W00tstock 5.0 - George RR Martin vs. Paul and Storm
Paul and Storm launch W00tstock 5.0 with \
https://www.youtube.com/watch?v=w5vw9RTVky4
almost 3 years ago
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https://www.lesswrong.com/posts/yT22RcWrxZcXyGjsA/how-to-have-polygenically-screened-children
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How to have Polygenically Screened Children - LessWrong
Polygenic screening is a method for modifying the traits of future children via embryo selection. If that sounds like gobbledygook, then think of it a bit like choosing stats for your baby. …
https://www.lesswrong.com/posts/yT22RcWrxZcXyGjsA/how-to-have-polygenically-screened-children
almost 3 years ago
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halp my mom has turned into a crypto bro
about 3 years ago
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good plank
about 3 years ago
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went to a talk on zen last night where the speaker mentioned he always picks up and handles his phone with two hands as a ritual to show reverence for how powerful (good and bad) a tool it can be
about 3 years ago
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time for the yearly re-read
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The Pursuit of Happiness
The Pursuit of Emptiness by John Perry Barlow Happiness is the absence of the striving for happiness. - Chuang-Tzu (350 B.C.) Chuang-Tzu had it right. No more need be said. But such is human nature th...
https://www.evernote.com/shard/s97/client/snv?isnewsnv=true¬eGuid=a67168d7-66f0-49f8-8cbd-a8b23431b63e¬eKey=1a497bc796793656&sn=https%3A%2F%2Fwww.evernote.com%2Fshard%2Fs97%2Fsh%2Fa67168d7-66f0-49f8-8cbd-a8b23431b63e%2F1a497bc796793656&title=The%2BPursuit%2Bof%2BHappiness
about 3 years ago
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monday poetry 🤗
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Poems To Live By - For A New Beginning
http://www.stevenkharper.com/foranewbeginning.html
about 3 years ago
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kensho (awakening experiences) as “anti-trauma”
about 3 years ago
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TIL!
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Stendhal syndrome - Wikipedia
https://en.wikipedia.org/wiki/Stendhal_syndrome
about 3 years ago
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type 2 fun is fun
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A supposedly fun thing I'll definitely do again
https://arman.do/tri
about 3 years ago
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enlightenment is arguably the most import thing a human can learn, why are we so bad at studying this phenomenon?
@sashac.bsky.social
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Hey, why aren't we doing more research about spiritual awakening
We know shockingly little about one of the most important human phenomena
https://open.substack.com/pub/sashachapin/p/hey-why-arent-we-doing-more-research?r=2mjya&utm_medium=ios&utm_campaign=post
about 3 years ago
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Remembering this paper exists never ceases to blow my mind
https://www.pnas.org/doi/full/10.1073/pnas.1322174111
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Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans | Proceedings of the National Academy of Sciences
Excessive or persistent proinflammatory cytokine production plays a central role in autoimmune diseases. Acute activation of the sympathetic nervou...
https://www.pnas.org/doi/full/10.1073/pnas.1322174111
about 3 years ago
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wrote a blag https://arman.do/todo
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My to-do list addiction as a high leverage meta-habit
https://arman.do/todo
about 3 years ago
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Was trying to find this quote I couldn't remember, googled fruitlessly for ten minutes then asked GPT4 and it nailed it on the first try. The world has changed, the future is here
about 3 years ago
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now entering my favorite phase of race training: the carbo load
about 3 years ago
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🤔
about 3 years ago
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https://scottaaronson.blog/?p=7134
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On overexcitable children
Wilbur and Orville are circumnavigating the Ohio cornfield in their Flyer. Children from the nearby farms have run over to watch, point, and gawk. But their parents know better. An amusing toy, not…
https://scottaaronson.blog/?p=7134
about 3 years ago
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I need to become a minister to officiate my brother’s wedding—what’s the best “church” for this? Looking for something a bit less silly than FSM, but with similar vibes: humanism, secularism, cheekiness
about 3 years ago
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“are the bad boys playing smash or harry potter”
about 3 years ago
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happy St Patrick’s day my skoot pals
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A Biologist's St. Patrick's Day Song
A 200-year-old Irish classic!\r \r Lyrics:\r In the year of our lord eighteen hundred and eleven\r On March the seventeenth day\r I will raise up a beer and I'll raise up a cheer\r For Saccharomyces cerevisiae\r Here's to brewers yeast, that humblest of all beast\r Producing carbon gas reducing acetaldehyde\r But my friends that isn't all -- it makes ethyl alcohol\r That is what the yeast excretes and that's what we imbibe\r \r Anaerobic respiration*\r Also known as fermentation\r NADH oxidation\r Give me a beer\r \r [CHORUS]\r \r My intestinal wall absorbs that ethanol\r And soon it passes through my blood-brain barrier\r There's a girl in the next seat who I didn't think that sweet\r But after a few drinks I want to marry her\r I guess it's not surprising, my dopamine is rising\r And my glutamate receptors are all shot\r I'd surely be bemoaning all the extra serotonin\r But my judgement is impaired and my confidence is not\r \r Allosteric modulation\r No Long Term Potentiation\r Hastens my inebriation\r Give me a beer\r \r [CHORUS]\r \r When ethanol is in me, some shows up in my kidneys\r And inhibits vasopressin by degrees \r A decrease in aquaporins hinders water re-absorption\r And pretty soon I really have to pee\r Well my liver breaks it down so my body can rebound\r By my store of glycogen is soon depleted\r And tomorrow when I'm sober I will also be hungover\r Cause I flushed electrolytes that my nerves and muscles needed\r \r Diuretic activation\r Urination urination \r Urination dehydration\r Give me a beer\r \r [CHORUS]\r \r Happy St. Pat's\r \r *Actually, this isn't true. While both anaerobic respiration and fermentation occur without the use of oxygen, anaerobic respiration utilizes the electron transport chain to generate ATP, while fermentation does not. My bad. I would have remembered that if I wasn't trying so hard to rhyme. A new corrected version is now up on my channel: http://www.youtube.com/watch?v=L6dzUOYTQtQ\r \r CHORDS: \r \r Intro: \r D DAG / bm A\r D D A G / bm A G D\r G D A G / G D G A\r G D A bm / G D A D\r \r Pre - chorus:\r G D A bm / G D A\r \r Chorus (Li-Diddly-I):\r G D A bm A\r G D A D\r \r Verse:\r D DAG / Bm A\r D D A G / Bm A G D\r G D A G / bm A\r G D A bm / G D A D
https://www.youtube.com/watch?v=oax3cUFsBSw
about 3 years ago
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Anyone else read Existential Kink? Just finished, loved it, now in my top ten
about 3 years ago
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Good ep. “We all feel like we have limited time but that’s really not the case. What we have is limited energy.” https://pca.st/episode/b9288d9e-6f08-40a0-ac22-bd5a312a702c
about 3 years ago
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virginia peanuts >>> all other peanuts
about 3 years ago
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reposted by
Armand
michael lai
about 3 years ago
no better way to start the day than volunteering with friends back at glide memorial church serving breakfast to the elderly & homeless 🙏🏻
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bday bsky 😇
about 3 years ago
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gm 🤙 @ryan.bsky.social
about 3 years ago
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Hamming questions
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Questions · Patrick Collison
https://patrickcollison.com/questions
about 3 years ago
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shal'kek nem'ron 🖖
about 3 years ago
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met all the bluesky celebrities last night ama
about 3 years ago
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reposted by
Armand
Noah J. Nelson, Immersonaut Prime
about 3 years ago
But they were all of them deceived, for another app was made.
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bringin back bsky ski pics
over 3 years ago
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propranolol is a v special molecule (for some ppl) ✨
over 3 years ago
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rapa + acarbose extend lifespan by ~30% in mice 🤯 can’t wait to see human trials for this https://onlinelibrary.wiley.com/doi/10.1111/acel.13724#acel13724-fig-0001
over 3 years ago
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