Joana Segura-Martinez
@joanasgrmrtnz.bsky.social
📤 32
📥 46
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pinned post!
Happy to share it with all of you! 🎉 Thank you to María and the whole lab
add a skeleton here at some point
about 1 month ago
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Joana Segura-Martinez
Carlos Estella
25 days ago
Se busca candidat@ para solicitar un contrato postdoctoral en nuestro grupo de investigación (morfogénesis y respuesta al estrés) del
@cbm-csic-uam.bsky.social
@csic.es
. Interesados no duden en contactar con nosotros. Se agradece RT.
#sciencejobs
#postdoct
www.fundacionareces.es/fundacionare...
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Joana Segura-Martinez
Centro de Biología Molecular Severo Ochoa
29 days ago
Ir más despacio puede hacer a las células más flexibles. Un estudio del grupo de María Gómez Vicentefranqueira @GenomeFun revela que la velocidad a la que se leen los genes influye en la identidad celular y en su capacidad de cambiar de estado.
www.cbm.uam.es/index.php/20...
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Ir más despacio para ser más flexible: la velocidad de lectura de los genes influye en la identidad celular - Centro de Biología Molecular Severo Ochoa
Todas las células del cuerpo tienen el mismo ADN, pero no todas hacen lo mismo. Una neurona y una célula de la piel, por ejemplo, activan genes distintos. La gran […]
https://www.cbm.uam.es/index.php/2026/05/08/ir-mas-despacio-para-ser-mas-flexible-la-velocidad-de-lectura-de-los-genes-influye-en-la-identidad-celular/?lang=es
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Happy to share it with all of you! 🎉 Thank you to María and the whole lab
add a skeleton here at some point
about 1 month ago
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Sometimes I get beautiful images 🥰
about 2 months ago
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reposted by
Joana Segura-Martinez
Genome Function Lab
2 months ago
Superinspiring!-as always
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Joana Segura-Martinez
Fundación Científica de la Asociación Española Contra el Cáncer
3 months ago
💚Recuerdos del III Encuentro Investigadores Contra el Cáncer💚 Momentos que nos recuerdan por qué investigamos. Gracias a todas las personas que formáis esta gran comunidad.
#SomosComunidadAECC
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Joana Segura-Martinez
Neuroepigenetics of brain physiology and pathology Lab
3 months ago
Happy to share our first preprint! Led by
@joseruiziglesias.bsky.social
— EpiFlow: multidimensional single-cell epigenetic profiling by spectral flow cytometry Many thanks to
@cbm-csic-uam.bsky.social
,
@ageinves.bsky.social
and Fundación Ramón Areces for their support
www.biorxiv.org/content/10.6...
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EpiFlow: multidimensional single-cell epigenetic profiling by spectral flow cytometry
The epigenetic landscape of individual cells determines their identity and function, yet current methods for profiling chromatin modifications at single-cell resolution remain low-throughput, costly, or limited in parametric depth. Here we present EpiFlow, a spectral flow cytometry-based platform that enables the simultaneous quantification of 16 epigenetic markers, including histone post-translational modifications, DNA methylation, and hydroxymethylation, at the single-cell level. We demonstrate that EpiFlow is robust across species from yeast to mammals and resolves biologically meaningful epigenetic transitions during the cell cycle, stem cell differentiation, germinal centre B cell maturation, diabetic liver remodelling, and seizure-induced chromatin reprogramming. High-dimensional integration of EpiFlow data enables cell-type classification based solely on epigenetic profiles in liver, brain, blood, and cancer. Furthermore, EpiFlow detects on-target and off-target/indirect effects of epigenetic drugs in a high-throughput-compatible format. Collectively, these results establish EpiFlow as a broadly applicable platform for single-cell epigenetic analysis in basic, pharmaceutical, and translational research. ### Competing Interest Statement The authors have declared no competing interest. Agencia Estatal de Investigación, PID2022-137384OA-I00 (ERDF /EU), RYC2021-031713-I (European Union NextGenerationEU/PRTR), EUR2024-153539, CNS2024-154632 Fundación Ramón Areces, CIVP22A7609
https://www.biorxiv.org/content/10.64898/2026.03.16.711606v1
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Yesterday, I had the privilege of attending the 3rd Meeting of Researchers Against Cancer, organised by
@contracancerinv.bsky.social
. It was a pleasure to exchange ideas with clinicians, researchers and patients. Thank you for supporting our research.
3 months ago
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reposted by
Joana Segura-Martinez
Genome Function Lab
3 months ago
Our postdoctoral researcher
@joanasgrmrtnz.bsky.social
, together with other researchers from
@cbm-csic-uam.bsky.social
, has participated in the video by
@contracancerinv.bsky.social
to commemorate **Women’s Day (#8M)** to recognize the strength, dedication and talent of women in science 💜
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The best thing about our lab is the mix of cultures. Happy Chinese new year all! 🐴
add a skeleton here at some point
4 months ago
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reposted by
Joana Segura-Martinez
Jesús Rafael RODRIGUEZ-AGUILERA
4 months ago
🧬 Inspiring talk and great coffee-side discussions with Dr. Francesca Mattiroli from
@hubrechtinstitute.bsky.social
, as part of the 27th Severo Ochoa Seminar Cycle at
@cbm-csic-uam.bsky.social
.🔬☕️
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reposted by
Joana Segura-Martinez
Centro de Biología Molecular Severo Ochoa
4 months ago
Celebramos el
#11F
con una foto de nuestras compañeras científicas, técnicas, gestoras, etc., en el CBM. 👩🔬💫 ¡Por más visibilidad, igualdad y oportunidades para las mujeres en ciencia!
#MujeresYCiencia
#diadelamujerylaninaenlaciencia
#TodasHacemosCiencia
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reposted by
Joana Segura-Martinez
ME Torres-Padilla
4 months ago
Particularly excited to announce "In Formation" 👉Vernissage 17h00 Munich *5th of July* @Muffatwerk 1st exhibition of Art&Science work from 4 artists, including
annadumitriu.co.uk
+
@replifate.bsky.social
Helen Pynor,Solveig Lill & Pei-Ying Lin
replifate.eu/event/in-for...
😇STAY TUNED 4more info
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Events for February 2026
We are thrilled to announce In Formation, the first exhibition featuring work from four artist-in-residence projects that bring art into the heart of scientific stem cell and epigenetics research. ...
https://replifate.eu/event/in-formation-the-first-exhibition-featuring-work-from-four-artist-in-residence-projects/
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Orgullosa de formar parte de la red de investigadoras de la Fundación
@contracancerinv.bsky.social
#investigadorascontraelcancer
4 months ago
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reposted by
Joana Segura-Martinez
Aura Carreira
6 months ago
🚨 Exciting news! Our latest study is out in Nature Communications! We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair. 🔗
rdcu.be/eT1R9
#CancerResearch
#BRCA2
#Genomics
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A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription - Nature Communications
Pathogenic BRCA2 truncating variants in heterozygosis drive distinct cancer-linked mechanisms. Here the authors show that one causes PARPi sensitivity and HR loss via haploinsufficiency, while another...
https://www.nature.com/articles/s41467-025-67209-2
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reposted by
Joana Segura-Martinez
Jesús Rafael RODRIGUEZ-AGUILERA
6 months ago
⚗️🧪 Hoy tocó desayuno de celebración en el
@genomefun.bsky.social
y coincidió con el
#DíaDelQuímico
🧬🧫
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reposted by
Joana Segura-Martinez
Jesús Rafael RODRIGUEZ-AGUILERA
7 months ago
🏵 ¡La celebración por el
#DíaDeMuertos
llegó al laboratorio de la Organización Funcional del Genoma de Mamíferos! 🧬
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reposted by
Joana Segura-Martinez
Centro de Biología Molecular Severo Ochoa
7 months ago
Mil gracias a Julia Otero y todo el equipo de
@juliaenlaonda.bsky.social
por contar a vuestra audiencia lo que hacemos en el CBM, lo que llevamos haciendo 50 años siguiendo la estela de Severo Ochoa. ¡Por otros cincuenta años más del CBM y de
#JELO
!
@ondacero.es
@csic.es
@uam.es
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reposted by
Joana Segura-Martinez
Genome Function Lab
8 months ago
The
@cbm-csic-uam.bsky.social
has celebrated its Golden Jubilee with two days filled with inspiring talks. We had the joy of hearing from outstanding scientists — including Nobel Prize laureates and leading figures in molecular biology — we were truly honored to have spoken with Dr. Svante Pääbo
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reposted by
Joana Segura-Martinez
Emilio Lecona
10 months ago
We are looking for a candidate to apply to a
#MSCA
Postdoctoral Fellowship in our lab in the @CBM_CSIC_UAM, working on the connections between DNA replication dynamics, replication stress and genomic instability in cáncer. Contact us if you are interested and please retweet.
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It's Science... 🧪
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First human genome from ancient Egypt sequenced from 4,800-year-old teeth
Forty years after the first effort to extract mummy DNA, researchers have finally generated a full genome sequence from an ancient Egyptian.
https://www.nature.com/articles/d41586-025-02102-y?utm_source=Live+Audience&utm_campaign=f6ff7df86f-nature-briefing-daily-20250703&utm_medium=email&utm_term=0_-33f35e09ea-50024132
11 months ago
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Congratulations to all 🎉 Terrific work 👇🏼
add a skeleton here at some point
11 months ago
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reposted by
Joana Segura-Martinez
Centro de Biología Molecular Severo Ochoa
11 months ago
¿Te interesa el cruce entre arte y ciencia? Este viernes 4 de julio a las 12:00, ven a la charla de la artista residente RepliFate Helen Pynor y a la mesa redonda con científic@s del CBM y CNIO. 📍 Evento en inglés con subtítulos en vivo en español 🎟️ Entrada libre ¡Te esperamos!
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reposted by
Joana Segura-Martinez
Centro de Biología Molecular Severo Ochoa
12 months ago
¡
#arteyciencia
en el CBM! Durante dos semanas tenemos con nosotros a la artista autraliana Helen Pynor, como parte del programa "Artists in Residence" de la red doctoral europea RepliFate. Trabajará con Emilio Lecona y María Gomez, IPs de esta red en el CBM.
@csic.es
@uam.es
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reposted by
Joana Segura-Martinez
Centro de Biología Molecular Severo Ochoa
12 months ago
La semana pasada recibimos en el CBM a 7 estudiantes del programa Científic@s en prácticas. Pasaron cinco días increíbles en los laboratorios de Miguel Manzanares, María Gómez y Natalia Azpiazu. ¡Gracias a l@s investigador@s por su generosidad y a l@s chic@s por su entusiasmo! 🥼
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So grateful to have reconnected with my former boss and mentor — such an inspiring scientist and person. I hope we can stay in touch and maybe even do some science together again! 😊
add a skeleton here at some point
12 months ago
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you reached the end!!
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