Nico Barros
@nicobarrosid.bsky.social
š¤ 962
š„ 76
š 37
Transplant Infectious Diseases Indiana University
A must read.
www.idsociety.org/globalassets...
@germhuntermd.bsky.social
@natebahrid.bsky.social
@fungaldoc.bsky.social
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https://www.idsociety.org/globalassets/idsa/practice-guidelines/histo-2025/pico-a-manuscript_final-2.pdf
4 months ago
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Cool article!
@drboulware.bsky.social
academic.oup.com/cid/advance-...
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Revisiting Immune-Mediated Mechanisms as Drivers of Cryptococcal Immune Reconstitution Inflammatory Syndrome
Hyunah Yoon, MD MS, Liise-anne Pirofski, MD, David R Boulware, MD MPH; Revisiting Immune-Mediated Mechanisms as Drivers of Cryptococcal Immune Reconstituti
https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciaf328/8163483?redirectedFrom=fulltext
5 months ago
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reposted by
Nico Barros
Ilan Schwartz
5 months ago
Addressing Antifungal Drug Resistance ā A āOne HealthāOne Worldā Challenge
@grthompsonmd.bsky.social
and Angel Desai
www.nejm.org/doi/full/10....
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Addressing Antifungal Drug Resistance ā A āOne HealthāOne Worldā Challenge | NEJM
Use of some antifungal pesticides may select for resistant fungi in the environment, which can then endanger human health. Coordinated regulatory processes in this area are important.
https://www.nejm.org/doi/full/10.1056/NEJMp2416548?query=WB
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Cannot agree more with
@germhuntermd.bsky.social
@fungaldoc.bsky.social
@natebahrid.bsky.social
"Better awareness, diagnostic testing practices, and reporting are needed to improve patient outcomes and enhance our understanding of coccidioidomycosis epidemiology"
jamanetwork.com/journals/jam...
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Estimated Burden of Coccidioidomycosis
This cross-sectional study generates a systematic and rigorous estimate of national incident symptomatic coccidioidomycosis cases by developing a model to account for cases missed through national sur...
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2834845
6 months ago
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Histoplasma working group ISHAM. Let's do it! 90-90-90 for 2030!
6 months ago
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reposted by
Nico Barros
Ilan Schwartz
6 months ago
Interferon-Ī³ therapy in patients with refractory disseminated
#coccidioidomycosis
Steve Holland and colleagues in
@cidjournal.bsky.social
academic.oup.com/cid/advance-...
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Interferon-Ī³ therapy in patients with refractory disseminated coccidioidomycosis
Abstract. Refractory disseminated coccidioidomycosis (DCM) is a severe disease with limited treatment options. This report reviews our own and prior publis
https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciaf286/8152940?redirectedFrom=fulltext
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Benedict K. and colleagues estimate that the US fungal disease related economic burden to be 19.4 billion dollar (with Dr. Evil sound effect)!!!
academic.oup.com/ofid/article...
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Economic Burden of Fungal Diseases in the United States
We conservatively estimated the U.S. economic burden of fungal diseases as $11.5 billion in 2019: direct medical costs ($7.5 billion), productivity loss du
https://academic.oup.com/ofid/article/9/4/ofac097/6553135
6 months ago
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Saving the best for last, Histoplasma working group ISHAM2025 Foz do IguaƧu, Brazil
6 months ago
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Michael Mansour presenting about "Augmenting neutrophil function as a therapeutic strategy for high risk-patients" Next level stuff!
@mansourlab.bsky.social
@mgh-id.bsky.social
6 months ago
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journals.asm.org/doi/10.1128/...
Great paper!
@germhuntermd.bsky.social
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Practical Guidance for Clinical Microbiology Laboratories: Antibody and antigen detection methods for dimorphic fungal infections | Clinical Microbiology Reviews
SUMMARYAntibody and antigen detection assays continue to play a significant role in the diagnosis of dimorphic fungal pathogens, including Blastomyces dermatitidis complex, Coccidioides immitis/posada...
https://journals.asm.org/doi/10.1128/cmr.00005-20
6 months ago
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reposted by
Nico Barros
Ilan Schwartz
8 months ago
Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter PK study for Screening Antifungal Exposure in Intensive Care Units (SAFE-ICU) J Roberts etc TLDR: ++variable, need tailored approach w TDM
link.springer.com/article/10.1...
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Update on the Clinical Practice Guidelines for treatment of Histoplasmosis. Thank you to all the authors
@fungaldoc.bsky.social
@germhuntermd.bsky.social
@jobadd.bsky.social
@iddoc4kids.bsky.social
Nathan Bahr
www.idsociety.org/practice-gui...
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Histoplasmosis (2025)
https://www.idsociety.org/practice-guideline/histoplasmosis-2025/
8 months ago
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reposted by
Nico Barros
Ilan Schwartz
9 months ago
From rising
#TxID
star (and a Canadian, no less), Patrick Tam
@tamckpatrick.bsky.social
HOPE in every breath and heartbeat: Understanding transplant eligibility, access barriers, and clinical outcomes in thoracic transplantation in persons with HIV
www.jhltopen.org/article/S295...
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HOPE in every breath and heartbeat: Understanding transplant eligibility, access barriers, and clinical outcomes in thoracic transplantation in persons with HIV
Persons with HIV (PWH) are living longer, leading to increased end-organ disease from chronic illness. Organ transplantation improves survival in patients with end-organ disease yet remains a constrai...
https://www.jhltopen.org/article/S2950-1334(25)00033-3/fulltext
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Histoplasmosis screening was positive in 9.1% of PLWHIV with clinical manifestations suggestive of histoplasmosis (including fever, night sweats and weight loss) in a Brazilian center. More screening is required for early diagnosis and improved outcomes.
academic.oup.com/mmy/advance-...
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Histoplasmosis screening using urinary antigen detection in people living with HIV in Southern Brazil
Abstract. Histoplasmosis is a life-threatening opportunistic infection in individuals with advanced HIV disease (AHD), particularly in endemic regions such
https://academic.oup.com/mmy/advance-article/doi/10.1093/mmy/myaf017/8029899?searchresult=1
9 months ago
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Fungal sensitization syndrome may be more prevalent than currently thought. This article examines asthma as a potential coccidiodiomycosis complication.
onlinelibrary.wiley.com/doi/10.1111/...
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Investigating Asthma After Coccidioidomycosis Among Patients With Commercial Health Insurance, United States, 2017ā2022
Background The relationship between asthma and coccidioidomycosis has not been fully described. We have hypothesised that Coccidioides could trigger inflammatory airway responses, similar to other f...
https://onlinelibrary.wiley.com/doi/10.1111/myc.70033
9 months ago
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If it's written by
@kottonnelson.bsky.social
, it is a must read! Concise expert insight into the utility of Immune monitoring assays for Cytomegalovirus.
journals.lww.com/transplantjo...
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Immune Monitoring Assays: Predicting Cytomegalovirus and... : Transplantation
An abstract is unavailable.
https://journals.lww.com/transplantjournal/fulltext/2025/03000/immune_monitoring_assays__predicting.3.aspx
9 months ago
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What an amazing valentines gift!
pubmed.ncbi.nlm.nih.gov/39956284/
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Complement and fungal diseases - PubMed
Complement and fungal diseases
https://pubmed.ncbi.nlm.nih.gov/39956284/
9 months ago
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A must read...amazing collaboration between different societies Super good article. Plus it has Michael K. Mansour
@mansourlab.bsky.social
as an author, boom!!
www.thelancet.com/journals/lan...
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Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM
Candida species are the predominant cause of fungal infections in patients treated in hospital, contributing substantially to morbidity and mortality. Candidaemia and other forms of invasive candidias...
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00749-7/fulltext
9 months ago
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One of the largest reports on pediatric histoplasmosis.
academic.oup.com/jpids/advanc...
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Retrospective Investigation of Pediatric Histoplasmosis Diagnosed at a Tertiary Childrenās Hospital in an Endemic Area over 11 years
AbstractBackground. Most histoplasmosis data are from adults. We describe pediatric histoplasmosis diagnosed at a tertiary pediatric care center in an ende
https://academic.oup.com/jpids/advance-article-abstract/doi/10.1093/jpids/piaf007/8011365?redirectedFrom=fulltext&login=false
9 months ago
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This is a great commentary challenging the use of antibiotics for SBP prophylaxis in patients with cirrhosis.
academic.oup.com/cid/advance-...
I've added this review article by
@arunasubramanian.bsky.social
as it provides context to the question (great read).
journals.lww.com/hepcomm/full...
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Rethinking Antibiotic Prophylaxis for Spontaneous Bacterial Peritonitis in Patients with Cirrhosis: First, Do No Harm
Abstract. Antibiotic prophylaxis for spontaneous bacterial peritonitis (SBPPr) in patients with cirrhosis has been considered standard of care since the 19
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaf047/7997050
9 months ago
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Expanding our pool (and knowledge) Great article about the long term outcome of HBV viremic allograft use in seronegative liver and kidney transplant recipients.
journals.lww.com/journalacs/a...
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Friend or Foe? Safety and Efficacy of Hepatitis B Viremic... : Journal of the American College of Surgeons
T+ and NAT-negative (ā) allografts in seronegative recipients. Study Design: All recipients of an HBV core antibody-positive (HBcAb+) LT or KT were prospectively evaluated at a single transplant ce...
https://journals.lww.com/journalacs/abstract/9900/friend_or_foe__safety_and_efficacy_of_hepatitis_b.1130.aspx
9 months ago
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Two good reads to accompany the Saturday morning coffee:
doi.org/10.1093/ofid...
(Breakthrough invasive mold infections in hematological cases)
academic.oup.com/ofid/article...
(Adenovirus incidence on pediatric SOT)
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Breakthrough Invasive Mold Infections in Hematologic Cases: Relevance of the Host's Factors
This retrospective study evaluating breakthrough invasive mould infections occurring among hematological patients highlights that host factors, including p
https://doi.org/10.1093/ofid/ofaf025
9 months ago
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Fun things to read and keep us entertained during these difficult times. "Surveillance and prevention of infection in clinical xenotransplantation"
journals.asm.org/doi/10.1128/...
Amazing article by Adam Stewart and Jay Fishman
10 months ago
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Check out our editorial "Beyond the test: moving forward with transplant candidates testing positive for COVID-19" Since I wrote it with
@kottonnelson.bsky.social
, can I say that I'm a grownup, or not just yet? We discuss an interesting Transplantation article:
journals.lww.com/transplantjo...
10 months ago
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What an awesome start for cocci this 2025! Outcomes of cocci in Ab+ SOTs after stopping antifungal prophy
journals.lww.com/transplantjo...
Antifungal prophy for Cocci: how long
journals.lww.com/transplantjo...
Should we treat mild cocci in immunocompetent host
academic.oup.com/cid/advance-...
10 months ago
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reposted by
Nico Barros
TransplantID.Net - American Society of Transplantation
10 months ago
Journal of Fungi review of
#Histoplasmosis
in solid organ
#transplant
by
@nicobarrosid.bsky.social
and L. Joseph Wheat of MiraVista Labs šØOpen accessšØ š„Great tables!š„ Open Access articles always prioritized by
transplantid.net
https://buff.ly/4aovOY7
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This guideline sought to provide updated recommendations on corticosteroid use for adults with sepsis, ARDS, and CAP
jamanetwork.com/journals/jam...
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Corticosteroids for Sepsis, ARDS, or Community-Acquired Pneumonia
This JAMA Clinical Guidelines Synopsis summarizes the 2024 Society of Critical Care Medicine guidelines on use of corticosteroids in sepsis, acute respiratory distress syndrome, and community-acquired...
https://jamanetwork.com/journals/jama/article-abstract/2828913
10 months ago
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#vaccinesavelives
Expanded recommendations to include pneumococcal conjugate vaccination for adults >50.
www.cdc.gov/mmwr/volumes...
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Expanded Recommendations for Use of Pneumococcal ...
This report describes CDCās updated pneumococcal conjugate vaccine recommendation for all adults aged ā„50 years who are PCV-naĆÆve or who have unknown vaccination history.
https://www.cdc.gov/mmwr/volumes/74/wr/mm7401a1.htm?s_cid=mm7401a1_w
10 months ago
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Geographic distribution of endemic mycoses 2.0! Let's leave the "historical distribution maps" in the history books and replace them for 21st century driven data.
@fungaldoc.bsky.social
@julioczuniga1.bsky.social
academic.oup.com/ofid/advance...
11 months ago
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Infectious Diseases Clinics of North America just published reviews of: Histo, Blasto, Mucor, Dematiaceous, invasive candidiasis, climate change medical mycology, fungal nomenclature, and culture-independent diagnostics.
www.sciencedirect.com/journal/infe...
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Infectious Disease Clinics of North America | ScienceDirect.com by ElsevierScienceDirect
Read the latest articles of Infectious Disease Clinics of North America at ScienceDirect.com, Elsevierās leading platform of peer-reviewed scholarly literature
https://www.sciencedirect.com/journal/infectious-disease-clinics-of-north-america/articles-in-press
11 months ago
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Very nice study describing the clinical aspects of this amazing fungi in transplant recipients.
@fungaldoc.bsky.social
@julioczuniga1.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...
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Presentation and Outcomes of Histoplasmosis in Transplant Recipients: A Retrospective SingleāCentre Cohort Study
Histoplasmosis was more common among transplant recipients after the first year of transplant. Transplant recipients had more disseminated disease and higher, but not significant mortality at 90 days
https://onlinelibrary.wiley.com/doi/10.1111/tid.14421
11 months ago
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Guys, you gotta stop fertilizing your weed with bat guano.
academic.oup.com/ofid/article...
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Histoplasmosis Associated With Bat Guano Exposure in Cannabis Growers: 2 Cases
Abstract. Histoplasma capsulatum is a pathogenic dimorphic fungus with evolving epidemiology. Initially described as endemic to the Ohio and Mississippi ri
https://academic.oup.com/ofid/article/11/12/ofae711/7917418?login=false
11 months ago
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reposted by
Nico Barros
Camille Nelson Kotton
12 months ago
The ACIP 2025 vaccine schedule for adults by medical condition (as well as age) is now available - with some great updates
www.cdc.gov/vaccines/hcp...
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reposted by
Nico Barros
Ricardo M. La Hoz
12 months ago
The results of the SOT subgroup analysis of the SOLTICE Phase III RCT (Maribavir vs. IAT) are consistent with those of the overall population. > Effectiveness < Discontinuations.
#TxID
#IDSky
#ViroSky
#MedSky
pubmed.ncbi.nlm.nih.gov/39613120/
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Maribavir for refractory cytomegalovirus infection (with or without resistance) in solid organ transplant recipients: subgroup analysis of the phase 3 randomized SOLSTICE study - PubMed
ClinicalTrials.gov; NCT02931539 DATA AVAILABILITY STATEMENT: The datasets, including the redacted study protocol, redacted statistical analysis plan, and individual participants data supporting the re...
https://pubmed.ncbi.nlm.nih.gov/39613120/
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Despite the risk of selection bias, the current study does an excellent job in underscoring the need for expanded screening and awareness of chagas disease among transplant candidates. It also shows that we need better access to monitoring tests.
academic.oup.com/ofid/article...
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Prevalence of Trypanosoma cruzi Infection in Solid Organ Transplant Recipients: A Neglected Disease in America
This study reports a 4.8% prevalence of T. cruzi infection among 1,523 individuals who required solid organ transplantation from 2019 to 2023, with lung an
https://academic.oup.com/ofid/article/11/12/ofae650/7887509
12 months ago
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A monumental ruling from the Secretary of the Health and Human Services. Huge round of applause to Dr. Durand and the HOPE investigators.
www.federalregister.gov/documents/20...
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Organ Procurement and Transplantation: Implementation of the HIV Organ Policy Equity (HOPE) Act
The Department of Health and Human Services (HHS) amends the regulations implementing the National Organ Transplant Act of 1984, as amended (NOTA), to remove clinical research and institutional review...
https://www.federalregister.gov/documents/2024/11/27/2024-27410/organ-procurement-and-transplantation-implementation-of-the-hiv-organ-policy-equity-hope-act
12 months ago
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Very comprehensive and helpful guideline for clinicians
pubmed.ncbi.nlm.nih.gov/39536464/
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Prevention and Treatment of Cancer-Related Infections, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology - PubMed
There is an increased risk of infection in patients with cancer that results in higher morbidity and mortality. Several risk factors can predispose these patients to infectious complications. Some suc...
https://pubmed.ncbi.nlm.nih.gov/39536464/
12 months ago
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OMGerms! Another amazing review article in NEJM, this time, is about C. auris. Candida auris Infections | New England Journal of Medicine
www.nejm.org/doi/full/10....
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Candida auris Infections | NEJM
C. auris, a serious public health threat that may have emerged because of climate change, persists on human skin and inanimate objects, frequently causing difficult-to-control outbreaks in health c...
https://www.nejm.org/doi/full/10.1056/NEJMra2402635
12 months ago
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NEJM is on fire! What a great review.
#transplantid.net
12 months ago
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www.nejm.org/doi/full/10....
This is great!
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Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections | NEJM
Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain. In a multicenter, non...
https://www.nejm.org/doi/full/10.1056/NEJMoa2404991
12 months ago
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