Part of a very important reassessment of IgM's role in immunity.

Vibrio2026 - Submit your abstract by June 15, and join us in Berlin for this wonderful conference in September!! event.fourwaves.com/vibrio2026

Pathogenic CD4⁺ T cells in experimental uveitis share key features with those seen across immune-mediated inflammatory diseases, highlighting common pathways driving chronic inflammation 🧬 🔗 vist.ly/55ib7 #Immunology #Autoimmunity #Tcells

Asking for #help -has anyone tried or #recommend #commercial #crystallography company for #TCR-#peptide #MHC, specifically mouse class II (I-Ab) with self peptide and #CD4 #TCR.

Delighted to share my PhD work "Coincident epithelial signals restrain commensal-specific CD8αβ+ T cells in the intestine" We made tools to track commensal-specific CD8 T cells so we could better understand this enigmatic population and see what happens when immunity to the microbiome goes awry.

Really great work from @harrison-lab.bsky.social on a really understudied area. Well worth a read!

Please repost! This comes from the good people at ChimeraX, who produce powerful up-to-date software to study protein (etc) structures, which are FREE to the community. 🙏 To stay viable and serve us, they need an experienced structural biologist to assume the leadership role on a funded project.

Another twist to why newborn babies more vulnerable to infection. Beyond immune cell immaturity, layering, active suppression... maternal pathogen-targeted antibodies still protect. Grateful @Nature sharing this hopefully uplifting glass half (99.9%)-full perspective www.nature.com/articles/s41...

Check out this squid-vibrio postdoc position at Penn State with my colleague Tim Miyashiro, especially if you have a background in proteomics/metabolomics. psu.wd1.myworkdayjobs.com/PSU_Academic...

If anyone interested in #postdoc #opportunities in our lab, please let us know. marie-sklodowska-curie-actions.ec.europa.eu/node/1495

May you live in interesting times...

Attending #BSI25? 📣 Meet our Editor-in-Chief, Simon Milling! Join us at the BSI stand this evening (18:00–19:30) in the exhibition hall to hear more about Discovery Immunology. Come say hello! 👋

Eh, does anyone know why bovine serum albumin (from Sigma at least) has tripled in price?

Interesting 🧵. IANAE so won’t comment on the science beyond noting that phase separation (in biology) is highly contentious (see e.g. genesdev.cshlp.org/content/33/2...). But it does bring up issues around publishing and editorial decisions 1/n

Populist Dems won. Moderate Dems won. We won in blue states. We won in purple states. Maybe the take is that (a) people think Trump is out of control; and (b) people like Dems when we're taking a stand and fighting for what we believe in - as we have been for the last month.

Happy to share new work from #theonlylabever, lead by the phenomenal @sltai.bsky.social - who developed a tool to study the biology of ILC3s, identifying their role in controlling CSF2-dependent myeloid cells. 🤗 @mucosalimmunol.bsky.social @societymucosalimm.bsky.social OA: doi.org/10.1016/j.mu...

For the #lovers of #TCRs -we are looking for #postdocs with interest in #functional and #mutational studies -dare to express 700 #self #antigen #specific #TCRs and #study them in #depth!!!!

I've noted for a long time a desire among many to try & write particular people out of the narrative of the history of Treg research. This review, by the one person everyone agrees is pivotal, provides an accurate assessment for those who don't know the field: www.annualreviews.org/content/jour...

Séamus Heaney was also uncontactable as he was sailing when he won for literature in '95

Anyone have any expertise/experience with interrogating SNP/InDel in a mouse genome using a reference genome. We have an alignment and are using Integrated Genomics Viewer, but are having trouble figuring some stuff out.

With deep gratitude, we thank Dr. Marc Jenkins for his decades of leadership, mentorship, and dedication to the Center for Immunology. The foundation he built will guide and inspire us for years to come.

Gianna Hammer & I are thrilled to co-Chair the 64th @midwinter-immun.bsky.social Conference of Immunologists Jan. 24-27, 2026. Join us & an amazing lineup of speakers including Carla Rothlin as Dan Campbell memorial lecturer for some exciting science in lovely Asilomar, CA! www.midwconfimmunol.org

Ugh. So many businesses thrive only by amplifying insecurities and making us feel inadequate: Not good enough, not beautiful enough, not clean enough, not rich enough, not thin enough, not popular enough, not tech savvy enough. EFF THAT. Don’t buy what they’re selling. You’re wonderful as you are.

Studying ecoimmunology? 🌍🧬 Submit your work to Discovery Immunology’s new Ecoimmunology Special Collection, exploring how ecological factors shape immune responses in humans & animals. 📢 Editors: Dr Iris Mair & Prof Kathryn Else 🔗 https://bit.ly/4lZX3NM ##Ecoimmunology #Immunology

Does anyone have any recommendations for a company/service that can sequence a mouse genome (B6 background) and provide analysis to a reference genome?

🐭 How does microbial exposure shape mouse model outcomes? A new Discovery Immunology study compares naturalization methods - co-housing, feralization, or both, and reveals distinct effects on gut immunity and microbiota. 🔗 https://bit.ly/44md5LQ ##Microbiome #Immunology

Super excited to announce that MRC has funded a new Centre of Research Excellence in Exposome Immunology. Working together, Manchester and Oxford are going to tackle a major challenge of our times. For those who wonder what the Exposome is - see yesterday's posts! www.ukri.org/news/centre-...

Writing a paper? Join us tomorrow at 12:00 BST for a free webinar with OUP Publisher Rachel Moriarty & our very own EIC Simon Milling. Essential tips on journal selection, peer review, and maximising impact. Register here: https://bit.ly/44ARC1p

Great piece re how to tackle reproducibility/fraud in science. Like many things in life, policing is a blunt tool, we should tackle the underlying causes of these issues. academic.oup.com/jimmunol/art...

Does anyone have DNA/ear biopsy from SJL (CD45.1) mice from Taconic or Charles River (originating from there, even if they've been in-house for a long time that's fine) that they can share? I don't have much reach here, would appreciate people sharing the post.

New immunological discoveries deserve wide reach. With read & publish deals, eligible authors can publish open access in Discovery Immunology for free! 🚀 Find out if you’re eligible here: bit.ly/4no9OTy

Lawmakers in Congress should not be buying, trading, and owning individual stocks. Period. It’s long past time to BAN Congressional stock trading.

📢 Final call! Submissions for the Re-discovering Myeloid Cells Special Collection close end of June 2025. Share your latest insights into myeloid cell biology, function, and pathology. Don’t miss out! 🔗 https://bit.ly/43OULe9

I thought this was really interesting. Somatic hypermutation can generate new specificities not present in the germline. Hard to quantify how prevalent such specificities are in the immune repertoire, but it would help prevent holes in the repertoire www.cell.com/immunity/ful...

Excited to share that our study, on how T cells selectively sense foreign antigens with single-molecule sensitivity, is out! This work was led by the brilliant Will White, and done in collaboration with Jay Groves and David Baker @uwproteindesign.bsky.social www.pnas.org/doi/10.1073/...

From bench to bedside, better models mean better arthritis therapies! 💡🧬 Explore this open access guide to standardizing murine arthritis scoring for clearer, comparable results. Full article: https://bit.ly/4mEgigp #InflammatoryArthritis #RheumatoidArthritis #AnimalModels #Immunology

Discovery Immunology publishes sound science on novel immune mechanisms in humans and animals. We've published some great papers. Publishing here, with the British Society for Immunology @britsocimm.bsky.social also helps support the immunology community @discovimmunol.bsky.social

⏳ Final call! The Re-discovering Myeloid Cells collection closes for submissions at the end of this month. Got research on monocytes, macrophages, or other myeloid cells? 🧬 Now’s the time to submit! 📢 Don’t miss out, submit today: https://bit.ly/4kLSs0L #Immunology #MyeloidCells #Macrophages

📢 Calling all immunology researchers! Submit your ground-breaking discoveries to Discovery Immunology - an Open Access journal by @britsocimm.bsky.social Fast online publication, expert editorial board, and global visibility await! 🔬🌍 📝 Learn more: https://bit.ly/3TXQOgF #Immunology

Our open access journal @discovimmunol.bsky.social is waiting for your immunology research and review papers. Submitting to this journal is a great way to get your research out there and to support the immunology community.

Are you working in cellular, molecular or comparative immunology? If yes, do consider the BSI's newest open access journal @discovimmunol.bsky.social

NIH Extends the ESI eligibility window drugmonkey.wordpress.com/2025/05/21/n...

Have novel findings in cellular, molecular or comparative immunology? Discovery Immunology is accepting submissions! 🔍 Original research, reviews, short reports & more 💡 Veterinary studies now welcome 🔗 Call for papers: bit.ly/3WmPhl3

What do rewilding, dirty mice & tidal rhythms have to do with immunity? "Context matters: Immunology meets ecology" introduces ecoimmunology - a field exploring immune variation in the real world. A must-read for researchers rethinking immunity 🌱 🔗 bit.ly/3Sg9rvC

Lets introduce #ecoimmunology - a field exploring immune variation in the real world. Take a look @discovimmunol.bsky.social

1/2 T cells friends. We are doing some in vitro experiments with a TCR transgenic that's on a RAG-/- background, so there is no endogenous TCR rearrangement. It breeds poorly. What do you think about an experiment where our input cells are a pool from male and female mice together with female BMDC?

Emerging evidence links Gamma Delta (γδ) T cell changes in the uterus to pregnancy disorders like recurrent miscarriage and preterm birth. Could they be targets for future therapies? 🔍 Full review: bit.ly/44xC6Uu #Fertility #Immunology #WomensHealth

Working on B cell function, regulation and clinical studies? Do think about submitting your next paper in this B Cell and Immune Regulation special collection in @imtadvances.bsky.social

I'm seeing a lot about how Europe needs to become a force in science as NIH support declines, & the potential to recruit scientists from the US arises. I think this misses a fundamental point. Europe doesn't lag behind the US because the scientists are less smart/capable....

🚨🚨 Dear friends in North America: I will be taking a 1-year sabbatical at @uwmadisonmmi.bsky.social with the wonderful @markjmandel.bsky.social (bringing the #mucus back to the marine world) from August 2025. If you want to meet up, let me know! Please share