Brant Isakson (@brantisakson.bsky.social)

Delighted to share ongoing translation of our discovery that alpha globin-eNOS is a potent regulator of NO in endothelium. In this work, the mechanism is confirmed in humans with alpha thalassemia, and our HbaX peptide used to dilate sickle cell arteries n/🧵 www.ahajournals.org/doi/abs/10.1...

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Sickle Trait and Alpha Thalassemia Increase NOS-Dependent Vasodilation of Human Arteries Through Disruption of Endothelial Hemoglobin-eNOS Interactions | Circulation BACKGROUND: Severe malaria is associated with impaired nitric oxide (NO) synthase (NOS)–dependent vasodilation, and reversal of this deficit improves survival in murine models. Malaria might have sele... https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.123.066003?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed