Our new review in @natbiomedeng.nature.com is out! RNA-loaded lipid nanoparticles (LNPs) have huge potential—but their strong liver and immune cell uptake has mostly confined them to vaccines and liver therapies. We explore how to move beyond those limits. free to read 🔗 rdcu.be/eLxGs

🚨 Our new #preprint is out! doi.org/10.1101/2025... We used #PerturbMap spatial functional genomics in pancreatic cancer to track tumor clone dynamics and uncover how extracellular factors like Serpine1 and Serpinb2 drive immune evasion. 🧵 (1/8)

Thrilled to share that our work from Trumpp Lab @hi-stem @dkfz.bsky.social is out in Nature. We provide the first single-cell data on neurons infiltrating pancreatic tumors, offering new insights into cancer therapy. #cancerneuroscience @cn-hd.bsky.social www.nature.com/articles/s41...

Immunology will be for everyone, everywhere, everyday, from driving foundational research to reaping the benefits for health. 🌎 Immunoschool 2025 is open for anyone looking to learn more about key immunotherapy advances over the last decade. FREE TO REGISTER: www.eventbrite.com/e/internatio...

The incidence of early-onset colorectal #cancer is surging By 2030, 1/3 of all CRCs will occur before the typical recommended screening age of 50 years In this #Cell commentary, Mauri et al. discuss the potential causes 🧪- and the importance of determining "tumor age" www.cell.com/cell/fulltex...

First lab Bluesky post! Happy to share new papers: PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac... PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...

I am so excited to share the biggest (and best) part of my #PhD in @maxreichertmd.bsky.social lab We show how inter/intra-tumoral #heterogeneity impacts plasticity and treatment resistance by using #PDAC #organoids @natureportfolio.bsky.social www.nature.com/articles/s41...

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

#InterferonPower! Elewaut, @obenaufa.bsky.social &co show @ Nature that inflammatory monocytes can acquire MHC-class I from tumor cells & locally activate CD8 T cells, given that the capacity of the tumor to shut down type I #IFNs & upreg PGE2 is reverted! www.nature.com/articles/s41...

#PancreaticCancer research starter pack. 65 of 150. Room for 85 more on this 1st starter pack. Who did I miss? go.bsky.app/FDafAW