@jmoronconcepcion.bsky.social
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anesthesiology.wustl.edu/study-identi...
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Study identifies gene that may influence opioid addiction risk | Anesthesiology | Washington University School of Medicine in St. Louis
Researchers at WashU Medicine have identified a gene that may help explain why some individuals are more likely than others to develop opioid addiction. The study builds on human genetic studies sugge...
https://anesthesiology.wustl.edu/study-identifies-gene-that-may-influence-opioid-addiction-risk/
about 1 month ago
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Last paper by Jessica Higginbotham on how environmental enrichment impact fentanyl reinstatement.
www.eurekalert.org/news-release...
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How enriching the environment may combat fentanyl addiction
Rat study shows that introducing new objects in a nonsocial environment dampens fentanyl use over time and relapse-like behavior triggered by stress.
https://www.eurekalert.org/news-releases/1122430
about 2 months ago
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reposted by
US Association for the Study of Pain
4 months ago
Interested in the intersection of pain and substance abuse? Check out this Symposium during the USASP annual meeting titled, "Neural Insights of Pain in the Context of Opioid Use and Misuse". Wednesday March 25, 2026 11:45AM - 1:15 PM EST
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@flybottleescape.bsky.social
made it to the news in Spain! Congrats my friend!
elpais.com/salud-y-bien...
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Un interruptor del dolor en el cerebro: un experimento logra acabar con el sufrimiento sin efectos secundarios
Un estudio en ratones prueba que es posible eliminar la sensaciĂłn de dolor a la vez que se evita el riesgo de adicciĂłn de los opioides
https://elpais.com/salud-y-bienestar/2026-01-09/un-interruptor-del-dolor-en-el-cerebro-un-experimento-logra-acabar-con-el-sufrimiento-sin-efectos-secundarios.html
5 months ago
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New work from the lab shows that object-based environmental enrichment, even in the absence of social enrichment, is sufficient to blunt fentanyl use, facilitate extinction, and constrain stress-induced reinstatement. Work done by @jessinbotham
biorxiv.org/content/10.6...
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Environmental Enrichment Attenuates Fentanyl-Seeking Behavior and Protects Against Stress-Induced Reinstatement in Both Male and Female Rats
Environmental enrichment (EE) reduces vulnerability to multiple drugs of abuse, yet its impact on fentanyl use and relapse-like behavior remains unclear. Here, we tested whether long-term, non-social,...
https://biorxiv.org/content/10.64898/2025.12.02.691896v1
6 months ago
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New study on the role of hippocampal SK2 channels in the encoding and retrieval of morphine-induced associative memories.
link.springer.com/article/10.1...
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Modulation of dorsal hippocampal SK2 channels regulates morphine-enhanced neuronal oscillations and morphine-induced contextual memory encoding and retrieval - Scientific Reports
Persistent maladaptive drug-context associations are a key component of relapse vulnerability and pose a major obstacle in treating opioid use disorder. Although the dorsal hippocampus (dHPC) is criti...
https://link.springer.com/article/10.1038/s41598-025-24819-6?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20251120&utm_content=10.1038/s41598-025-24819-6
7 months ago
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reposted by
Niko Massaly
8 months ago
🚨 Please RT! We’re recruiting a motivated postdoc to dissect the neurocircuits of affective pain. Expertise in behavioral models of pain/SUDs, stereotaxy, microscopy, opto/chemogenetics, or fiber photometry encouraged. Apply 👉
recruit.apo.ucla.edu/JPF10647
#Neuroscience
#Postdoc
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Postdoctoral Research Position
University of California, Los Angeles is hiring. Apply now!
http://recruit.apo.ucla.edu/JPF10647
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We published this study a couple of months back but has now been featured by
@washumedicine.bsky.social
. In this study in collaboration with Bill Carlezon and Domi Burek at McLean we assessed how pain impacts sleep architecture.
source.washu.edu/2025/09/mous...
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Mouse study links chronic pain to disrupted sleep patterns
Researchers at Washington University in St. Louis School of Medicine have developed the first mouse model to replicate the disrupted sleep patterns seen in people with chronic pain.
https://source.washu.edu/2025/09/mouse-study-links-chronic-pain-to-disrupted-sleep-patterns/
9 months ago
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New study from the lab on alcohol/pain and taste aversion.
add a skeleton here at some point
9 months ago
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Our new paper on the effects of pain on sleep architecture in collaboration with Bill Carlezon and Erik Musiek is now out at
@npp-journal.bsky.social
. Work conducted by Domi Burek and Nisa Ibrahim.
www.nature.com/articles/s41...
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Inflammatory pain in mice induces light cycle-dependent effects on sleep architecture - Neuropsychopharmacology
Neuropsychopharmacology - Inflammatory pain in mice induces light cycle-dependent effects on sleep architecture
https://www.nature.com/articles/s41386-025-02152-w?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20250622&utm_content=10.1038/s41386-025-02152-w
12 months ago
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www.psypost.org/estrogen-cur...
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Estrogen curbs fentanyl intake by suppressing brain’s reward response
A new study in Neuron suggests that men may be biologically more vulnerable to misusing opioids like fentanyl in response to pain. The findings point to estrogen’s ability to suppress brain reward cir...
https://www.psypost.org/estrogen-curbs-fentanyl-intake-by-suppressing-brains-reward-response/
about 1 year ago
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So honored to have our work highlighted in The Scientist
www.the-scientist.com/female-sex-h...
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Female Sex Hormones Reduced Fentanyl Use in Rats
Exploring how sex differences regulate dopamine responses could inform novel interventions to prevent or treat substance use disorders.
https://www.the-scientist.com/female-sex-hormones-reduced-fentanyl-use-in-rats-73002
about 1 year ago
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Amazing preview written by
@docbecca.bsky.social
on our latest manuscript on the sex dependent effects of pain on fentanyl intake at
@cp-neuron.bsky.social
add a skeleton here at some point
about 1 year ago
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Our research on alternative treatments for fentanyl overdoses using peripheral restricted opioid antagonists is highlighted in this podcast by Cambridge University. This work was conducted by the outstanding postdoc Dr Brian Ruyle
www.thenakedscientists.com/articles/int...
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Opioid overdose treatment bypasses brain, eases side effects
It may not be necessary to get drugs into the brain to block the lethal effects of a fentanyl overdose...
https://www.thenakedscientists.com/articles/interviews/opioid-overdose-treatment-bypasses-brain-eases-side-effects
about 1 year ago
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Higher opioid deaths among men may be due to sex hormones, new fentanyl study finds - New York Post
about 1 year ago
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Some media coverage of our study on the sex-dependent effects of pain on facilitated opioid intake:
medicine.washu.edu/news/female-...
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Female sex hormone protects against opioid misuse, rat study finds | WashU Medicine
Male – but not female – rats in chronic pain self-administer increasing amounts of fentanyl, which is prevented with estrogen treatment
https://medicine.washu.edu/news/female-sex-hormone-protects-against-opioid-misuse-rat-study-finds/
about 1 year ago
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New work from the lab published at
@cp-neuron.bsky.social
. In this study we dissect the role of hormonal regulation in pain-induced enhanced opioid intake in males. Work conducted by the super talented @jessinbotham
www.cell.com/neuron/fullt...
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Estradiol protects against pain-facilitated fentanyl use via suppression of opioid-evoked dopamine activity in males
Higginbotham et al. show that inflammatory pain increases opioid-evoked dopamine neuron activity to promote fentanyl use selectively in males. Ovarian hormones offer females protection, but estradiol’...
https://www.cell.com/neuron/fulltext/S0896-6273(25)00131-X
about 1 year ago
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JMC lab decoration
over 1 year ago
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Our new work on the use of peripheral restricted antagonists to prevent and rescue fentanyl induced respiratory depression without unwanted side effects such as aversive behavior is out now! Great work by lead author @brian_ruyle
elifesciences.org/for-the-pres...
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Researchers identify new therapeutic strategy for fentanyl overdose
Blocking peripheral opioid receptors with naloxone methiodide sufficiently prevents and reverses fentanyl-induced cardiorespiratory depression without causing the aversive effects of naloxone in roden...
https://elifesciences.org/for-the-press/dd8568c0/researchers-identify-new-therapeutic-strategy-for-fentanyl-overdose
over 1 year ago
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Our Neuroprep postbacc program at WashU is now accepting applications. This program offers 2 years of research intensive experience in neuroscience laboratories at WashU to help potential neuroscience graduate student applicants. Please apply now!
neuroprep.wustl.edu
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WashU Neuroprep
Outstanding training to ready scholars for graduate careers in neuroscience
https://neuroprep.wustl.edu
over 1 year ago
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reposted by
Fadel Zeidan
over 1 year ago
Heading to my first
#ACNP2024
! Will be sharing the stage with
@jmoronconcepcion.bsky.social
and
@marieeikemo.bsky.social
on Sunday 4-4:50pm to discuss Mechanisms Supporting Sex Differences in Opioid Use and Pain: From Preclinical to Clinical Studies.
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The JMC at WashU aims to dissect the intersection between pain and opioid use disorders to find better therapeutic approaches.
moronconcepcionlab.wustl.edu
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Moron-Concepcion Lab
A website by WashU Sites
https://moronconcepcionlab.wustl.edu/
over 1 year ago
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reposted by
Denise J. Cai, Ph.D.
over 1 year ago
We’re hiring tenure-track faculty focused on Systems &
#ComputationalNeuroscience
at the Friedman Brain Institute at Mount Sinai! We're starting to review applications so submit yours ASAP! 👇
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