🔍Salmonella enterica contaminates essential food sources and causes serious illness. Peter Katsande takes us behind the scenes of their latest #MGEN publication investigating its genetic profile in the food supply chain of Zimbabwe. Read the full blog🔗 microb.io/3NtC4GA

Structural insights into the antibacterial function of the Pseudomonas putida effector Tke5 @pbernalt6ss.bsky.social, David Albesa-Jové and coworkers link.springer.com/article/10.1...

JB Editor's Choice: Bhattarai, Harshey et al. propose a new model for YcgR::c-di-GMP regulation of flagellar motility in Salmonella/E. coli. They provide evidence for the first part of their model. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology

Structural insights into the assembly and evolution of a complex bacterial flagellar motor www.nature.com/articles/s41...

Host CD59 Potentiates the Type III Secretion System in Yersinia pseudotuberculosis www.biorxiv.org/content/10.6...

Type IV Secretion Systems: Reconciling Diversity Through a Unified Nomenclature url: academic.oup.com/femsre/artic...

Our first paper is out today in @natmicrobiol.nature.com! We introduce a prostate organoid model and show that UPEC invades prostate cells via FimH binding to the prostate-specific protein PAPP. A step toward targeted therapies against bacterial prostatitis. 🎉 #UTI #UPEC #Organoids #AMR

Type IV Secretion Systems: Reconciling Diversity Through a Unified Nomenclature url: academic.oup.com/femsre/artic...

Salmonella SPI2 evades detection by NAIP/NLRC4 despite utilization of a detectable needle www.biorxiv.org/content/10.6...

A comprehensive analysis of flagellar mutations in Vibrio cholerae: Trade-off mechanisms between motility loss and host adaptability www.biorxiv.org/content/10.6...

📣New preprint with @rberntsson.bsky.social👇We overturn the long-standing view that Gram-positive bacteria lack conjugative pili! We identify pili-forming proteins in a wide range of bacteria and show they're essential for the spread of #antibioticresistance #AMR 🧵1/6 www.biorxiv.org/content/10.6...

Assembly and glycosylation of Helicobacter pylori sheathed flagella www.biorxiv.org/content/10.6...

Cyclic-di-GMP controls Type III effector export and symptom development in Pseudomonas syringae infections via the export ATPase HrcN dx.plos.org/10.1371/jour...

Enteropathogenic E. coli-mediated Fast and Coordinated Ca²⁺ responses regulate NF-κB activation doi.org/10.7554/eLif...

Ultraweak interactions drive cap-mediated positioning and elongation of the bacterial flagellar filament www.nature.com/articles/s41...

Dynamic interaction of the Yersinia pseudotuberculosis type three secretion system proteins LcrV and LcrG - Mangu - 2026 - Protein Science - Wiley Online Library onlinelibrary.wiley.com/doi/full/10....

TTSS-2 virulence drives inflammatory destruction of the gut epithelial barrier and modulates inflammatory response profiles in the Salmonella-infected mouse guthttps://dx.plos.org/10.1371/journal.ppat.1013733

Checkout this article I found at PLOS: dx.plos.org/10.1371/jour...

Unravelling Salmonella Pathogenesis: Effector-Mediated Post-Translational Modifications, Alternative Therapies, and Advances in Rapid Detection | ACS Infectious Diseases pubs.acs.org/doi/10.1021/...

Exploiting Pseudomonas syringae Type 3 Secretion to Study Effector Contribution to Disease in Spinach | Molecular Plant-Microbe Interactions® apsjournals.apsnet.org/doi/10.1094/...

Full article: The ubiquitin system targets translocated EspH to proteasomal degradation www.tandfonline.com/doi/full/10....

An unexpected mechanism for population heterogeneity in the gut microbiome: www.cell.com/cell-host-mi...

Interplay between T3SS effectors, ExoY activation, and cGMP signaling in Pseudomonas aeruginosa infection nature.com/articles/s41...

Bimodal expression of Type 3 Secretion System 2 enables cooperative virulence among intracellular Salmonella Typhimurium dx.plos.org/10.1371/jour...

Typhoid toxin of Salmonella Typhi elicits host antimicrobial response during acute typhoid fever | EMBO Molecular Medicine www.embopress.org/doi/full/10....

Role of FlhF and its domains in the assembly of a polar flagellum in P. aeruginosa #JBacteriol from Deepti Jain journals.asm.org/doi/10.1128/...

Actin isoform–specific interactions revealed by Vibrio VopV actin-binding repeats | PNAS www.pnas.org/doi/abs/10.1...

Secreting bacteria undergo drastic changes. We found that in Yersinia, T3SS activation triggers rapid, large-scale reorganisation of chromosomal and plasmid DNA. This links secretion to growth inhibition-revealing a new connection between virulence and bacterial cell biology. doi.org/10.1016/j.ce...

Lithocholic acid induces T3SS-dependent formation of invasion-competent Shigella flexneri aggregates www.biorxiv.org/content/10.1...

#MicrobiologyMonday: The bacterial flagellum is built through a hierarchical assembly process and powered by a dynamic motor capable of astonishing speeds. What's new in our understanding of these complex nanomachines? Find out in #MMBRJournal: asm.social/2HB

Building the bacterial flagellum: coordinating regulation, dynamic assembly, and function | Microbiology and Molecular Biology Reviews journals.asm.org/doi/10.1128/...

Flagellar location determines the stability of bacterial surface entrapment | PNAS www.pnas.org/doi/10.1073/...

Swashing: a propulsion-independent form of bacterial surface migration | Journal of Bacteriology journals.asm.org/doi/10.1128/...

What if even the core of bacterial nanomachines wasn’t static? We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function. 🔗 www.nature.com/articles/s41... @kit.edu @t3sss.bsky.social

Continuous exchange of an inner-membrane ring component is required for assembly and function of the type III secretion system www.nature.com/articles/s41...

Structures of the sheathed flagellum reveal mechanisms of assembly and rotation in Vibrio cholerae www.nature.com/articles/s41...

In situ structures of the Legionella Dot/Icm T4SS identify the DotA–IcmX complex as the gatekeeper for effector translocation | PNAS www.pnas.org/doi/10.1073/...

Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky

TXSelect: A multi-task learning model to identify secretory effectors dx.plos.org/10.1371/jour...

Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses www.nature.com/articles/s41...

Salmonella multimutants enable efficient identification of SPI-2 effector protein function in gut inflammation and systemic colonization www.nature.com/articles/s41...

The Salmonella pathogenicity island 1 injectisome reprograms host cell translation to evade the inflammatory response www.nature.com/articles/s41...

Full article: Deletion of the hslV gene alleviates the virulence and lethality of Salmonella Typhimurium in hosts by modulating lon and T3SS-1 www.tandfonline.com/doi/full/10....

Transcriptomic and proteomic analysis of the effect of hydrogen peroxide on enterohemorrhagic Escherichia coli: Heliyon www.cell.com/heliyon/full...

Cooperative Binding of Cytosolic Type III Secretion System Proteins to the Injectisome Revealed by Live-Cell Single-Molecule Localization Microscopy www.biorxiv.org/content/10.1...

Long-term control of Salmonella after transient T3SS-2 inhibition www.biorxiv.org/content/10.1...

Bacterial effector OspB hijacks apoptosis through peptide-bond recombination of BH3 domain proteins: Cell Host & Microbe www.cell.com/cell-host-mi...

IscR-mediated sensing of iron-sulfur cluster demand coordinates virulence gene expression in Yersinia pseudotuberculosis www.biorxiv.org/content/10.1...

Celebrated every 15 October, Global Hand Washing Day aims to raise awareness of the importance of hand hygiene in curbing the transmission of certain diseases and the spread of antimicrobial resistance.

New in JB: Déraspe, Roy et al. perform a comparative genomics study of the PA7-clade of P. aeruginosa - now recognized as a distinct species, Pseudomonas paraeruginosa. This analysis revealed 2 sub-clades, the lack of T3SS & multiresistance. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology