Phosphorylation of rhizobial effector NopZ by soybean NORK promotes association with NENA and enhances nodulation www.nature.com/articles/s41...

T3SS effector and regulator discovery by predicting interacting partners of T3SS chaperones in Pseudomonas aeruginosa - Zhang - 2026 - Protein Science - Wiley Online Library onlinelibrary.wiley.com/doi/full/10....

@albertopmacho.bsky.social and I summarize advances in understanding how T3Es modulate cellular processes beyond immune signaling for colonization in COPB. Sabotage behind enemy lines: Bacterial hijacking of plant cellular functions www.sciencedirect.com/science/arti...

Regulator-derived growth and fitness costs of Salmonella SPI-2 expression are environment specific and T3SS independent https://www.biorxiv.org/content/10.64898/2026.04.10.717833v1

Enteropathogenic E. coli-mediated Fast and Coordinated Ca2+ responses regulate NF-κB activation www.biorxiv.org/content/10.1...

Global transcription factors analyses reveal hierarchy and synergism of regulatory networks and master virulence regulators in Pseudomonas aeruginosa doi.org/10.7554/eLif...

Regulator-derived growth and fitness costs of Salmonella SPI-2 expression are environment specific and T3SS independent www.biorxiv.org/content/10.6...

In @eLife.bsky.social: Gene synteny and translational coupling of sctS and sctT facilitate assembly of the unique helical T3SS export apparatus in Salmonella Typhimurium doi.org/10.7554/eLif...

Biochemist Elizabeth Bugie co-discovered streptomycin (with Selman Waksman), the first antibiotic against Mycobacterium tuberculosis. Waksman went on to win the 1952 Nobel Prize for Medicine & took full credit for the discovery. Bugie died #OTD in 2001. #WomenInSTEM #MatildaEffect (1/2)

In @eLife.bsky.social: Gene synteny and translational coupling of sctS and sctT facilitate assembly of the unique helical T3SS export apparatus in Salmonella Typhimurium doi.org/10.7554/eLif...

Enterohemorrhagic Escherichia coli senses colonic oxygen availability to modulate its virulence and colonization: iScience www.cell.com/iscience/ful...

The MarR Family Transcriptional Regulator EmrR Negatively Regulates the Type III Secretion System (T3SS) and Positively Modulates Pathogenicity in Dickeya oryzae - Lv - 2026 - Molecular Plant Pathology - Wiley Online Library bsppjournals.onlinelibrary.wiley.com/doi/10.1111/...

Class II chaperones: indispensable components of the Gram-negative bacterial T3SS as guardians of translocators link.springer.com/article/10.1...

Full article: High-throughput transposon sequencing identifies HprR as a key regulator of the LEE operon and virulence in E. coli O157:H7 www.tandfonline.com/doi/full/10....

Pathogen hijacks focal adhesion signaling by a T3SS effector CteX | PNAS www.pnas.org/doi/10.1073/...

#OTD in 1936, Danish seismologist Inge Lehmann wrote a famous letter to a colleague outlining her theory that seismic waves (P-waves) recorded from distant earthquakes indicated Earth had a solid inner core. Her discovery fundamentally changed our understanding of the Earth's interior. #WomenInSTEM

My latest News & Views in Nature Immunology explores work by Young et al. mapping how commensals could use T3SS to "talk" to our cells, fine-tuning our immune responses: rdcu.be/e9JSq @springernature.com Original: www.nature.com/articles/s41... @interactome.bsky.social @natmicrobiol.nature.com

Fis suppresses late-stage virulence gene expression in Yersinia pseudotuberculosis at environmental temperatures dx.plos.org/10.1371/jour...

Simultaneous inhibition of bacterial virulence and anti-phage defense systems by synergistic bacteriophage counter-defense proteins link.springer.com/article/10.1...

Catabolism of serine enantiomers represses enterohemorrhagic Escherichia coli virulence factors via modulation of the nitrogen stress response | PNAS www.pnas.org/doi/full/10....

Host adaptation in Salmonella enterica serovar Typhimurium: population structure, pathovariants, and genomic mechanisms | Applied and Environmental Microbiology journals.asm.org/doi/10.1128/...

Tumor-specific cytokine therapy mediated by engineered Salmonella with a synthetic protein delivery system www.nature.com/articles/s41...

DksA inhibitors against intracellular and persistent Salmonella are effective in acute models of infection | Science Advances www.science.org/doi/10.1126/...

Serine phosphorylation of CesT by the type III secretion system effectors NleH1 and NleH2 regulates antagonization of CsrA in enteropathogenic Escherichia coli | Infection and Immunity journals.asm.org/doi/10.1128/...

Active removal of inhibitory components drives the flagellar Type III Secretion Specificity Switch www.biorxiv.org/content/10.6...

Happy to share our latest work! Interplay between SpaO variants shapes the architecture of the Salmonella type III secretion sorting platform | mBio journals.asm.org/doi/full/10....

Host CD59 Potentiates the Type III Secretion System in Yersinia pseudotuberculosis www.biorxiv.org/content/10.6...

Gene synteny and translational coupling of sctS and sctT facilitate assembly of the unique helical T3SS export apparatus in Salmonella Typhimurium www.biorxiv.org/content/10.6...

I had the fun opportunity to write a Commentary for a JB paper by Bhattarai, Harshey et al. describing their Texas Two-Step model of cdG-mediated motility control. Commentary: pubmed.ncbi.nlm.nih.gov/41705806/ Paper: journals.asm.org/doi/10.1128/... @asm.org #JBacteriology

Differential targeting of human pyroptotic caspase-5 and caspase-4 by Shigella OspC2 and OspC3 | mBio journals.asm.org/doi/10.1128/...

Full article: Substrate secretion by the different EHEC secretion systems during its interaction with epithelial cells www.tandfonline.com/doi/full/10....

A type III secretion system is required for Bordetella atropi invasion of host cells in vivo dx.plos.org/10.1371/jour...

What does competition for iron look like for pathogens in different environments? We had the chance to contribute to this great paper looking at Salmonella in the gut with the Cunrath Lab (UoStrasbourg). Salmonella relies on siderophore exploitation at low pH url: academic.oup.com/microlife/ar...

📄 New paper out! Please check out our latest publication, where we show how the gatekeeper protein InvE orchestrates hierarchical type III secretion in Salmonella Typhimurium via oligomeric assembly. #T3SS #DNAPAINT www.pnas.org/doi/10.1073/...

Oligomeric assembly of the gatekeeper InvE orchestrates hierarchical type III protein secretion in Salmonella Typhimurium | PNAS www.pnas.org/doi/10.1073/...

#NatMicroPicks A bacterial symbiont wraps its flagllar filaments around its cell body to propel itself through narrow gut passages in its stinkbug host and hook flexibility is key for this 🪲🦠 by Yoshitomo Kikuchi & co @natcomms.nature.com www.nature.com/articles/s41...

Effector–host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation www.nature.com/articles/s41...

Pseudomonas syringae histidine kinase BvgS acts as the sensory receptor of plant-derived putrescine to activate the type III secretion system and enhance bacterial virulence www.sciencedirect.com/science/arti...

Decoding the host–pathogen proteomic dialogue using surface labeling tools - Dubois - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...

Canine Providencia alcalifaciens: virulence factors and phylogenetic analysis of an emerging enteropathogen Open Access www.microbiologyresearch.org/content/jour...

My time in @martinsteinegger.bsky.social's group is ending, but I’m staying in Korea to build a lab at Sungkyunkwan University School of Medicine. If you or someone you know is interested in molecular machine learning and open-source bioinformatics, please reach out. I am hiring! mirdita.org

PROTEINS: Structure, Function, and Bioinformatics | Protein Science Journal | Wiley Online Journal onlinelibrary.wiley.com/doi/10.1002/...

The gene moeA is involved in the structural colour of some bacterial colonies by modifying cell shape and colony organisation, thus causing a shift in reflected colour.

The persistent challenge of importing biological research materials to the Global South at a reasonable cost, within acceptable timeframes, and with manageable regulatory complexity stalls progress before research and innovation can even begin go.nature.com/48ZIPHr rdcu.be/eZond

Shigella OspF blocks rapid p38-dependent priming of the NAIP–NLRC4 inflammasome | PNAS www.pnas.org/doi/10.1073/...

A new mouse model of typhoid fever using Salmonella enterica serovar Paratyphi C as a surrogate pathogen | mBio journals.asm.org/doi/10.1128/...

🔍Salmonella enterica contaminates essential food sources and causes serious illness. Peter Katsande takes us behind the scenes of their latest #MGEN publication investigating its genetic profile in the food supply chain of Zimbabwe. Read the full blog🔗 microb.io/3NtC4GA

Structural insights into the antibacterial function of the Pseudomonas putida effector Tke5 @pbernalt6ss.bsky.social, David Albesa-Jové and coworkers link.springer.com/article/10.1...

JB Editor's Choice: Bhattarai, Harshey et al. propose a new model for YcgR::c-di-GMP regulation of flagellar motility in Salmonella/E. coli. They provide evidence for the first part of their model. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology

Structural insights into the assembly and evolution of a complex bacterial flagellar motor www.nature.com/articles/s41...