Dennis Frank
@denfra.bsky.social
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PhD student in Freiburg and meme enthusiast
reposted by
Dennis Frank
Robert Grosse @ grosselab
11 days ago
It was inspiring and fun hosting Patrick Lusk
@luskinglab.bsky.social
as our seminar guest, here looking at cell nuclei and peppers with AFM expert Dennis
@denfra.bsky.social
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reposted by
Dennis Frank
Robert Grosse @ grosselab
about 1 month ago
Svenja Ulferts
@sulferts.bsky.social
receiving a wonderful doctoral thesis award from our
@uni-freiburg.de
president 🥳🍾 - well done and well deserved!
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reposted by
Dennis Frank
Robert Grosse @ grosselab
2 months ago
we found that nuclear envelope rupture triggers rapid DIAPH3 formin influx to generate a actin mesh to prevent further chromatin leakage from damaged nuclei. thanks to Pitter Huesgen
@degradomics.bsky.social
and
@cibss.bsky.social
,
@chrkam.bsky.social
add a skeleton here at some point
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reposted by
Dennis Frank
The EMBO Journal
2 months ago
Nuclear rupture in confined cell migration triggers nuclear actin polymerization to limit chromatin leakage DDR sensor ATR protects against nuclear envelope rupture via formin phosphorylation inducing F-actin formation Christos Kamaras et al
@grosselab.bsky.social
www.embopress.org/doi/full/10....
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reposted by
Dennis Frank
Robert Grosse @ grosselab
4 months ago
Hi all, check out our new preprint where we uncover:"Regulation of YAP activity by nuclear G-actin binding",
www.biorxiv.org/cgi/content/...
#actin
#YAP/TAZ
#transcription
#nucleus
with help from Sonja-Verena Albers @archaellum.bsky.social
loading . . .
Regulation of YAP activity by nuclear G-actin binding
The Yes-associated protein YAP belongs to the TEAD (TEA/ATTS domain) transcriptional co-activators that shuttle between cytoplasm and nuclear compartment. YAP and its paralog TAZ (transcriptional co-a...
https://www.biorxiv.org/cgi/content/short/2025.07.30.667612v1
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