Introduction to the interventions tested in our @trr393.bsky.social consortium to improve #depression and #bipolardisorder Big thanks to @lisaleehr.bsky.social! @unimarburg.bsky.social @tudresden.bsky.social @uni-muenster.de @dfg.de @dgps.bsky.social link.springer.com/article/10.1...

Let's meet at the #DGPPN! Our members are happy to chat with you at our info desk in the exhibition hall, right across the main entrance - stop by to get to know the people behind the hashtag #SFBTRR393 👥 (also: we have sweets 🤭) #DGPPN2025 #DGPPNKongress

📄 New study published: Exploring the sustainability of treatment success over five years – key insights for clinical practice! 🔍 Read more here: doi.org/10.1159/0005... #Medicine #TreatmentSuccess #LongTermStudy #Research #Sustainability

Last week, 130 researchers of the #SFBTRR393 & invited guests gathered at Kulturrathaus Dresden for an inspiring retreat. 4 days of sharing recent results, discussing new directions, and strengthening collaborations across sites. More & more difficult to get everyone into one photo, but we managed!

During last week's retreat, we awarded #posterprizes to the best 3 of ~70 excellent #ECR posters. 🎉 Congratulations to winners Vera Ludwig, Alina Nostadt, Claudia Förster Ribet, Tung Anh Nguyen & Theresa Kolb - thank you to all ECRs for presenting your research and engaging in lively discussions!

🧠 Our CRC/TRR 393 consortium outlines key mechanisms of affective disorders — focusing on emotion regulation, expectation, social cognition, and cognitive-behavioral rhythms. Read here 👉 doi.org/10.1007/s001... @kanske.bsky.social @markuswohr.bsky.social @lisaleehr.bsky.social @trr393.bsky.social

📣 The ENIGMA study “Regional brain morphology and current antidepressant use” explores how antidepressant medication correlates with structural brain differences in Major Depressive Disorder across age and sex, drawing on data from 32 international cohorts. 🧠 🔗 Read it here: doi.org/10.1038/s413...

Please repost! I am looking for a PhD candidate in the area of Computational Cognitive Neuroscience to start in early 2026. The position is funded as part of the Excellence Cluster "The Adaptive Mind" at @jlugiessen.bsky.social. Please apply here until Nov 25: www.uni-giessen.de/de/ueber-uns...

A new publication, “Transdiagnostic alterations in white-matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium”, by ENIGMA Suicidal Thoughts & Behaviours Consortium (Translational Psychiatry www.nature.com/articles/s41...)

🧩 New article! Same same but different: Threat expectancy change and fear reduction as readouts of exposure rationales are only weakly associated to treatment outcome in anxiety disorders Now published in Behaviour Research and Therapy: 🔗 doi.org/10.1016/j.br... #AnxietyDisorders #Expectancy

😊 New publication! Joy Beyond Fear: Positive Emotions After Exposure in Patients with Anxiety Disorders and Their Link to Threat Expectancy and Treatment Outcome Now out in Behaviour Research and Therapy: 🔗 doi.org/10.1016/j.br... #AnxietyDisorders #ExposureTherapy #PositiveEmotions #Expectancy

🧠 New paper investigated how childhood maltreatment shapes structural brain connectivity across affective and psychotic disorders. Now out in European Neuropsychopharmacology: 🔗 authors.elsevier.com/sd/article/S... #Neuroscience #Psychiatry #BrainConnectivity #ChildhoodMaltreatment

🧠Out now @natcomms.nature.com ! Brain changes linked to childhood maltreatment are among the field's most published findings. Yet, we find extensive replication failure of gray matter correlates in three large cohorts (N=3225), consistent across subsamples, models and operationalizations🧵

The CRC/TRR 393 aims to unravel trajectories of depression & bipolar disorder by combining mobile assessments, neuroimaging, -omics & interventions in >1500 participants. A 12-year effort to decode mechanisms of recurrence & remission. Overview: 🔗 rdcu.be/eGtBy

🥳 Our study led by @edwardody.bsky.social from the @tnm-lab.bsky.social is published in the European Journal of Neuroscience. Take a look if you are interested in action-perception transition, readiness potential, and voluntariness of action! 📍https://onlinelibrary.wiley.com/doi/10.1111/ejn.70236

🎥 LOEWE DYNAMIC in 2 ½ min Not brand new, but still relevant: In this video introduction, Winfried Rief explains what the LOEWE Research Center DYNAMIC is all about – and how dynamic networks can help improve treatments. ▶️Watch here: www.youtube.com/watch?v=TR6F... (English subtitles available)

Neural correlates of human fear conditioning and sources of variability in 2199 individuals www.nature.com/articles/s41...

🧠 New paper out! Rashid, Kircher & Straube (2025) investigate temporal characteristics of hemodynamic responses during active vs. passive hand movements in schizophrenia spectrum disorder. 📄 Schizophrenia: 👉 doi.org/10.1038/s415...

@tnm-lab.bsky.social Kausalitätswahrnehmung, Erwartungen & fMRT begeistern dich? Bewirb dich auf die Promotionsstelle (3 Jahre, 75%) in Marburg (www.theadaptivemind.de) bis zum 17.08.: stellenangebote.uni-marburg.de/jobposting/1... #Job #Promotion #fMRI #Psychologie

🧠🗣️ I’m co-editing a Neuropsychologia Special Issue: “Language in Psychosis – A Multidisciplinary Approach” We welcome contributions on: • neural mechanisms • predictive processing • cognitive, computational & clinical perspectives 📅 Deadline: Sept 30, 2025 www.sciencedirect.com/special-issu...

Feeling excluded can distort your decisions! New study shows tDCS can buffer against the effects of social exclusion on decision-making. 🔗 academic.oup.com/scan/advance... #neuroscience #tDCS #socialexclusion #mentalhealth

Delay adaptation does not transfer between discrete button press actions and continuous control - Loes CJ van Dam, Svenja Kernig, Karina Lazarova, Melisa Ünal, Nicole Gappa, Benjamin Straube, Thomas SA Wallis, 2025 journals.sagepub.com/doi/10.1177/... @tsawallis.bsky.social

New manuscript! Together with Junqing Huang & @straubeb.bsky.social, we used an innovative paradigm & DDM to show that gesture's processing hierarchy from a behavioral perspective! Gestures are visual—but they’re also layered, structured, and unfold like language. 🧠🖐️ 👇👇👇 osf.io/r5nb9_v1

The #ClustersOfExcellence have been selected: today, the Excellence Commission approved 70 projects for funding. 45 clusters will continue and 25 will be newly established. Funding starts on 1 Jan 2026 for 7 years, with €539 million per year. The full list: www.dfg.de/resource/blo... 1/3

🧠✨ New publication in Brain Communications! Schizophrenia spectrum disorders & motor preparation: Aberrant pre-movement fMRI patterns in insula, putamen, cerebellum & angular gyrus 🔗 doi.org/10.1093/brai... #Schizophrenia #fMRI #ActionAwareness #CognitiveNeuroscience #Psychiatry

🚨 New in Molecular Psychiatry 🚨 DNA methylation as a potential marker for anxiety disorders & psychotherapy response: Longitudinal EWAS reveals epigenetic signatures linked to disease risk and CBT outcomes. 📖 doi.org/10.1038/s413... #Anxiety #Epigenetics #CBT #Psychiatry #PrecisionMedicine

How do patients with schizophrenia Spectrum Disorder perceive causality? We show altered reliance on spatial vs. temporal cues—and a growing bias to repeat prior choices over time. ➡️ doi.org/10.1038/s415... #Schizophrenia #Perception #Cognition #Neuroscience

Join the #SFBTRR393 in Marburg! Two open PhD positions (65%) in A04, investigating inflection signals in #depression using MRI, EMA & EEG. You’re passionate about translational #psychiatry and want to work in an interdisciplinary environment? Apply by April 27 via the official portal ⬇️ #ResearchJob

@trr393.bsky.social und @dpk-kongress.bsky.social Herzliche Einladung zu unserem Symposium zu den Schlüsselmechanismen der Trajektorien affektiver Erkrankungen

When listening to a story, earlier parts of the story (context) and the speaker's gestures help us predict and understand what they are saying. In a new preprint we show context and gestures have a push-pull synergy on neural response to linguistic information 👇🧵

In the light of #worldbipolarday, Prof. Dr. Dr. Michael Bauer, the #sfbtrr393 local spokesperson at @tudresden.bsky.social was interviewed about current developments in #bipolardisorder research: www.uni-marburg.de/en/trr-393/n...

And here the poster!

If you are at #CNS2025, check out this brilliant poster #F98 from @edwardody.bsky.social @straubeb.bsky.social where we probed for action-specific "quasi-predictive" effect independent of probability-based expectations!

🚀 Excited to share our new preprint led by my brilliant colleague Anna Petukhova @tnm-lab.bsky.social! We used a drift-diffusion model to show how local semantic predictability rapidly enhances evidence accumulation during language processing. #priming #ddm #prediction 🔗 shorturl.at/lP10h

Hi! We are the SFB/TRR 393 "Trajectories of Affective Disorders: Cognitive-Emotional Mechanisms of Symptom Change" - a transregional @dfg.de collaborative research center & interdisciplinary team of researchers working together to better understand what influences the course of affective disorders👇🏻🧵

Patients with schizophrenia spectrum disorders show reduced differentiation between self- and externally generated sensory input, particularly during tool use and bimodal feedback. 🔗Read more: www.nature.com/articles/s41... #Neuroimaging #Schizophrenia #PredictiveCoding #fMRI @cschmitter.bsky.social

Congratulations @cschmitter.bsky.social

Our project on sensory attenuation is featured in the uni magazine @unimarburg.bsky.social 🗞️ www.uni-marburg.de/de/aktuelles... A very nice summary of our work! Featuring a pic of the project's muscle: The Marburg HPC "MarC3", who did the heavy lifting in optimizing & inverting the models. 🤖💪

#PLOSONE: Modelling sensory attenuation as Bayesian causal inference across two datasets dx.plos.org/10.1371/jour... Congratulations @eckertal.bsky.social

This was a wonderful team effort within our collaborative cluster "The Adaptive Mind", with my P.I. Dominik Endres, @tnm-lab.bsky.social 's @straubeb.bsky.social @cschmitter.bsky.social, and Uni Gießen's Elena Fuehrer and Katja Fiehler.

📢 Stellenausschreibung im TNM-Lab: Qualifizierungsstelle (65%) mit Promotionsziel im SFB/TRR 393 an der Philipps-Universität Marburg. Forschung zu affektiven Störungen mit modernster Ausstattung (MRT, EEG). Bewerbungsfrist: 02.02.2025. stellenangebote.uni-marburg.de/jobposting/f...

Proud to debut in BlueSky with a fascinating new preprint from @tnm-lab.bsky.social @straubeb.bsky.social led by Edd Ody, where we used MVPA of EEG to show how motor preparation and sensory perception are related in action-effect contingency. 🔗https://shorturl.at/XZp5q 🧵👇

This review was fabulously led by Lukas Kirchner, with contributions by @maxberg91.bsky.social, @eckertal.bsky.social, @straubeb.bsky.social, and other Bluesky-less people. Thanks for the nice collaborative work!

Social expectations in depression Review by Lukas Kirchner, Tobias Kube, Max Berg, Anna-Lena Eckert, Benjamin Straube, Dominik Endres & Winfried Rief Web: go.nature.com/41kXLO1 PDF: rdcu.be/d2yHr #psychology #psychscisky #clinpsy

How do negative social expectations shape the onset, course, and severity of depression? Our review in @NatureRevPsych explores the cognitive and interpersonal mechanisms driving these processes, offering insights for intervention. Read it here: rdcu.be/d2ylD #Psychology #Depression #MentalHealth

I feel especially honored because the #DGPPN has awarded our paper with the DGPPN oral presentation abstract prize!🥳

Beyond proud to see this published in The Lancet Psychiatry authors.elsevier.com/sd/article/S22…. Together with my brilliant colleague & joint 1st author Kira Flinkenflügel we explored the prospective associations between cognitive performance, white matter integrity, and depressive disease course.

BLUESKY MEGA-THREAD Altmetric is thrilled and also LITERALLY RELIEVED to officially announce: We are now tracking research attention as it happens on Bluesky! We have been picking up posts on the site since late Oct. Our team is on Bluesky all day answering questions. Let's get into it!