@hasselljames.bsky.social
📤 1055
📥 6381
📝 10
Neuro/metabolism post doc @ CU Anschutz | Learning & Memory | 🐀🧠
reposted by
Steve Maren
4 months ago
🚨New paper alert! 🚨 Inactivation of the nucleus reuniens causes relapse of extinguished fear. Here we show this “circuit-induced relapse” depends on hippocampal fear memories and is mediated by hippocampal engrams. Congrats to the team!
loading . . .
Hippocampal ensembles regulate circuit-induced relapse of extinguished fear
Molecular Psychiatry - Hippocampal ensembles regulate circuit-induced relapse of extinguished fear
https://urldefense.com/v3/__https://rdcu.be/enulI__;!!DZ3fjg!4WTTn91dOHoOe1cBqHrKGrhe3zcbKCVveTwEAZCruquL5HfW7Sz8G238dSxm8-xiqrGNnbxhGxuSS0XeWAnerRlikeMArwW7cmI$
2
70
22
reposted by
Priya Prakash
4 months ago
Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now
@cp-immunity.bsky.social
! ➡️
www.cell.com/immunity/ful...
loading . . .
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease
Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...
https://www.cell.com/immunity/fulltext/S1074-7613(25)00192-X
4
68
27
reposted by
Science Rabbit
5 months ago
Fantastic new article by Dr. Christy Niemeyer on the disproportionate burden of Alzheimer's disease on women.
@csniemeyerphd.bsky.social
sciencerabbit.org/2025/04/04/w...
loading . . .
Why are women twice as likely to get Alzheimer’s disease?
Explore the complexities of Alzheimer's disease and its disproportionate impact on women, influenced by hormonal and societal factors.
https://sciencerabbit.org/2025/04/04/why-are-women-twice-as-likely-to-get-alzheimers-disease/
0
6
3
reposted by
Carl T. Bergstrom
6 months ago
This piece from
@tressiemcphd.bsky.social
starts with a bang and just gets better and better. Gift link.
loading . . .
Opinion | The Tech Fantasy That Powers A.I. Is Running on Fumes (Gift Article)
A.I. is just what we need in the post-fact era: less research and more predicting what we want to hear.
https://www.nytimes.com/2025/03/29/opinion/ai-tech-innovation.html?unlocked_article_code=1.7k4.oG8D.H6ureDIHnmAO&smid=url-share
51
1602
761
reposted by
Dr. Becca
6 months ago
I wrote a piece for
@thetransmitter.bsky.social
www.thetransmitter.org/sex-differen...
With the fate of NIH-funded research uncertain, it is extra important that the work we do now is most likely to benefit everyone. Adhering to SABV in the lab and in grant & paper review is the right thing to do.
loading . . .
Amid NIH upheaval, how to keep sex as a biological variable
Even in the absence of formal instruction to do so, we should continue to hold our colleagues accountable for SABV practices.
https://www.thetransmitter.org/sex-differences-in-the-brain/keep-sex-as-a-biological-variable-dont-let-nih-upheaval-turn-back-the-clock-on-scientific-rigor/
0
66
35
@aoc.bsky.social
and
@sanders.senate.gov
anti-oligarchy rally in Denver, CO!
loading . . .
6 months ago
0
10
0
reposted by
Kimberley Bruce
6 months ago
Thank you
@sanders.senate.gov
and
@aoc.bsky.social
for rallying us together, and not dividing us apart!
#denver
#fightoligarchy
0
14
2
reposted by
Kimberley Bruce
7 months ago
New review from the lab! Do
#microglia
metabolize
#fructose
in
#Alzheimers
Disease?
rdcu.be/edIRM
Big congrats to the first author @AnnaliseSturno for all her hard work 💪🏻👩🏻🔬💪🏻
0
15
5
Why would a commercial software use 0's for missing values????
7 months ago
0
0
0
reposted by
Kimberley Bruce
7 months ago
More than ever we need to talk about the importance of our "basic research" in public and political forums. Kudos to
#AnnaliseSturno
and
@neurohassell.bsky.social
for getting out there and sharing their work on fructose metabolism and Alzheimers Disease at
#Denver
#Capitol
0
5
4
reposted by
Christy Niemeyer, PhD
7 months ago
Today’s STEM Day at the capital was a success! My students worked so hard on making posters that were accessible and highlighted all the important work we are doing!
@projbridgeco.bsky.social
@cuanschutz.bsky.social
0
5
2
@lindseyforco.bsky.social
&
@shannonbird4co.bsky.social
I live in y'alls district and will be talking about the link between sugar on the 🧠 and Alzheimer's in
@drkimberleybruce.bsky.social
's lab at
@cuanschutz.bsky.social
with
@projbridgeco.bsky.social
. Hope to see y'all there!
7 months ago
0
6
4
reposted by
Kimberley Bruce
7 months ago
I continue to be blown away by the sub-cellular resolution that our new
#Nanolive
3D explorer allows. Look at these
#microglia
go!
loading . . .
1
5
3
reposted by
Stand Up for Science!
7 months ago
TODAY IS THE DAY! 🧪☀️⬇️ Join us at the Lincoln Memorial or your local site to Stand Up for Science!
16
1180
461
reposted by
Sketching Science
7 months ago
Your lab scissors are actually a parafilmase - a highly specialized enzyme that catalyzes the precise cutting of parafilm through a metal-dependent mechanism
2
187
39
reposted by
Center for Open Science
9 months ago
Join our monthly Getting Started on the OSF webinar every 2nd Monday at 11 AM ET! Learn how OSF supports open science and streamlines research workflows 🌟 Highlights: ✔ Guided feature tour ✔ Use case exploration ✔ Live Q&A 🔗 Register:
cos-io.zoom.us/webin...
0
8
7
reposted by
jenn m. jackson (they/them)
8 months ago
A Black woman named Aliyah was struggling to find work. So, she catfished herself and made a fake profile on LinkedIn named "Emily." Emily had the same qualifications as Aliyah but received 57.9% of interview invites while Aliyah received 8.9% This is what we mean when we say racism is systemic.
71
5129
1825
I think I finally got the hang of surface mount resistors. Version 7.1 is a different piecing together project for sure.
8 months ago
0
2
0
Back at it again!
@csniemeyerphd.bsky.social
@kravitzlab.com
8 months ago
1
3
0
reposted by
Carolyn Bertozzi
10 months ago
Exciting new discovery from colleagues
@stanfordmedicine.bsky.social
, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.
www.science.org/doi/10.1126/...
loading . . .
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies
Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...
https://www.science.org/doi/10.1126/science.abm6131
4
211
50
Question for science Bluesky. Does 4% PFA during cell fixation permeabilize cell membranes?
10 months ago
2
2
1
reposted by
Denise J. Cai, Ph.D.
10 months ago
🌟 Cai Lab Nature (
@natureportfolio.bsky.social
) paper alert! In work led by Joe Zaki, we find that rest periods after learning not only stabilize new memories BUT ALSO integrate new memories with older ones from days past! (1/10) Read it here:
www.nature.com/articles/s41...
8
261
95
reposted by
University of Colorado Anschutz
11 months ago
#CUAnschutz
researchers are among the first to recognize how Herpes simplex virus type 1 infiltrates the brain, leading to a better understanding of how it may trigger neurological diseases. The study was recently published in the Journal of Virology. ⬇️🧠
loading . . .
Silent Intruder: How the Cold Sore Virus Maps its Way Through the Brain
Silent Intruder: How the Cold Sore Virus Maps its Way Through the Brain
https://news.cuanschutz.edu/news-stories/silent-intruder-how-the-cold-sore-virus-maps-its-way-through-the-brain?utm_campaign=hsv1&utm_source=bluesky&utm_medium=social
0
18
7
reposted by
SJo
11 months ago
xcited to share our new results! We (huge team effort led by post-doc extraordinaire Sylvie Lesuis) examined the effects of acute stress on threat memory generalization and engram ensemble architecture.
www.sciencedirect.com/science/arti...
loading . . .
Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice
Stress induces aversive memory overgeneralization, a hallmark of many psychiatric disorders. Memories are encoded by a sparse ensemble of neurons acti…
https://www.sciencedirect.com/science/article/pii/S0092867424012169?dgcid=author
11
211
65
reposted by
Jonathan W. Gray
11 months ago
A quick note to all the NewSkys: there really isn’t algorithm here. We depend on each other to spread the word. So if you want others to see something, repost it. Liking something adds it to your feed but doesn’t surface it for others.
22
1155
607
you reached the end!!
feeds!
log in