Computational Systems Neuroscience (@nawrot.bsky.social)

The endocytic adaptor AP-2 maintains Purkinje cell function by balancing cerebellar parallel and climbing fiber synapses Tolve et al. demonstrate that AP-2 stabilizes GRID2IP to regulate synaptic function in Purkinje cells. Loss of AP-2 disrupts synaptic connectivity, alters network activity, and impacts motor coordinat... https://www.cell.com/cell-reports/fulltext/S2211-1247%2825%2900027-0