Aleksandra Filipovska
@filipovskalab.bsky.social
📤 102
📥 66
📝 4
reposted by
Aleksandra Filipovska
Hana Antonicka
3 months ago
Our story about FASTKD5 is now published at
@narjournal.bsky.social
It was an amazing collaboration with
@haukehillen.bsky.social
and Toni Barrientos’ labs.
doi.org/10.1093/nar/...
FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites
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FASTKD5 processes mitochondrial pre-mRNAs at noncanonical cleavage sites
Abstract. The first post-transcriptional step in mammalian mitochondrial gene expression, required for the synthesis of the 13 polypeptides encoded in mito
https://doi.org/10.1093/nar/gkaf665
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reposted by
Aleksandra Filipovska
Hana Antonicka
4 months ago
A great collaboration combining clinical and research data to describe mutations in FASTKD5 causing Leigh syndrome. Thank you all!
add a skeleton here at some point
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It takes two to TANGO2! TANGO2 binds the heat shock protein crystallin alpha B to prevent aggregation of the intermediate filament desmin and its loss models TANGO2-deficiency disorder Many thanks to our team, collaborators and reviewers
rdcu.be/epI3p
#metabolism
#mitochondria
#genetic
disorders
4 months ago
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reposted by
Aleksandra Filipovska
Nils-Göran Larsson
6 months ago
www.livescience.com/health/medic...
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'Breakthrough': 1 molecule may be promising treatment for family of devastating mitochondrial diseases
Scientists found a compound that appears to counter common mutations behind POLG-related diseases, rare conditions that harm mitochondrial DNA.
https://www.livescience.com/health/medicine-drugs/scientists-just-discovered-a-single-molecule-that-may-treat-rare-devastating-mitochondrial-diseases
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reposted by
Aleksandra Filipovska
MitoCarriers
6 months ago
Our paper is finally out: Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier | Science Advances
www.science.org/doi/10.1126/...
#mitochondria
#cryo-EM
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Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier
The mitochondrial pyruvate carrier transport mechanism is ΔpH driven and is inhibited competitively by distinct compound classes.
https://www.science.org/doi/10.1126/sciadv.adw1489
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reposted by
Aleksandra Filipovska
Hauke Hillen
6 months ago
Happy to share out latest collaborative work with the groups of Ricarda Richter-Dennerlein and Peter Rehling just out in
@natcomms.nature.com
. Great work led by two very talented PhD students - Franziska Finke (our lab) and Marleen Heinrichs (Richter-Dennerlein lab).
www.nature.com/articles/s41...
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Coupling of ribosome biogenesis and translation initiation in human mitochondria - Nature Communications
Mitochondrial ribosome biogenesis requires the assistance of multiple assembly factors. Here, the authors provide insights into the essential role of the GTPase MTG3 during small subunit biogenesis an...
https://www.nature.com/articles/s41467-025-58827-x
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reposted by
Aleksandra Filipovska
EMBO
6 months ago
Explore current research to better understand the roles of
#mitochondria
in our cells at the EMBO | FEBS Lecture Course "The evolving role of mitochondria in metabolism" in Belgrade, Serbia, 14–18 Sep Deadline: 1 Jun
meetings.embo.org/event/25-mit...
#EMBOmitochondria25
#metabolism
#EMBOevents
🧪
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The evolving role of mitochondria in metabolism
The history of mitochondria begins with their recognition as distinct cellular organelles in 1888 by Walther Flemming and the introduction of the term mitochondrion from the Greek roots meaning ‘thre…
https://meetings.embo.org/event/25-mitochondria
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reposted by
Aleksandra Filipovska
Mito@GU
6 months ago
New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
www.nature.com/articles/s41...
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Small molecules restore mutant mitochondrial DNA polymerase activity - Nature
An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.
https://www.nature.com/articles/s41586-025-08856-9
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reposted by
Aleksandra Filipovska
MitoCarriers
8 months ago
It is believed that proton conductance by the mitochondrial uncoupling protein (UCP1) is inhibited specifically by purine nucleotides, but we show that pyrimidine nucleotides also inhibit UCP1 with similar affinities in a pH-dependent manner.
#mitochondria
www.embopress.org/doi/full/10....
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Ready to make breakthroughs in gene editing and mitochondrial biology in sunny Western Australia? Join our vibrant team as a Research Associate or Research Fellow. Expertise in cryo-EM, cell imaging, or mammalian genetic screens is highly desirable
staff.curtin.edu.au/explore-care...
8 months ago
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reposted by
Aleksandra Filipovska
Jim Stewart
9 months ago
Another fantastic piece of work from Carlos Moraes' group. Using mitochondrial DdCBE base editors to correct a pathogenic mutation in our heteroplasmic m.5024C>T mice. 🧪
www.science.org/doi/10.1126/...
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Correcting a pathogenic mitochondrial DNA mutation by base editing in mice
A mitochondrial DNA editor can make compensatory corrections for a pathological mitochondrial DNA mutation in mice.
https://www.science.org/doi/10.1126/scitranslmed.adr0792
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New structural and functional analyses show that FASTKD4 supports non-canonical RNA processing and MT-ND3 mRNA stability. Thanks to all authors for their contributions and the reviewers for their kind advice!
academic.oup.com/nar/article/...
#RNA
#mitochondria
#mtDNA
10 months ago
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