I survived the 2025 EMBO protein quality control meeting - it was amazing despite a defective projector on day 1, and epileptic crisis on day 2, a black out in day 3, and we all got a shaky wake up call ~6am on day 5 by an earthquake… never a dull moment but most importantly great science

We ran over 200 eggaggregation experiments for Science Rendezvous - a blast!

Application deadline extended to Apr 15 for this summer's #Yeast #Genetics & #Genomics course at @cshlaboratory.bsky.social July22 - Aug12! Get a comprehensive education in all things yeast, from classical genetics through up-to-the-minute genomics. Don't miss out! meetings.cshl.edu/courses.aspx...

Here’s a quick throwback to celebrate the last day of winter: curling with the lab!

Some of you will recognize this - I am done with our CIHR application. Just in time to start teaching a big course section ✌️

Bioinformatics Job Opportunity Research Associate / Staff Scientist Vancouver Canada Join the Silent Genomes Project to provide an outstanding genetic variation database for Indigenous peoples of Canada to improve rare disease diagnosis tinyurl.com/bm4ptux3 Priority to Canadians Please repost

Job available for Full Professor Tier 1 Canada Research Chair (CRC) - Indigenous Health and Well-Being at the Faculty of Health Science, Simon Fraser University (RT 🙏🏼 please): www.sfu.ca/vpacademic/a...

I enjoyed both @cherisirois.bsky.social presentation and conversation about the publishing world and Cell Press today

With the help of e@UBC our BMB and MSL postdocs organized this great 1/2 day Academia to Industry workshop with a focus on entrepreneurship today

Even though David Baker's presentation was online, it was rad and inspiring. I really enjoyed today's session on machine learning at the 2025 PepTalk & BioLogic Summit

Calling early-career colleagues with stories of racism / sexism / microaggressions to share (anonymously or not) for an article someone I know is doing! Please send me a DM asap. They'd need to interview you tomorrow (Tues). It's important these stories are shared, so please do reach out!

Protein quality control is a tug-of-war between degradation machinery and chaperones that promote folding. Thrilled to see our latest manuscript is now published! 👇 Follow 🧵 for quick summary journals.biologists.com/jcs/article-...

CONGRATS to @supportourscience.bsky.social, Dr. Kaitlin Kharas, @sarahlaframboise.bsky.social & @cdrobich.bsky.social who were named "Nature's 10", a list of people who shaped science in 2024. #SupportOurScience achieved amazing things. The advocacy continues! www.nature.com/articles/d41...

ICYMI: Finland downgrades a bunch of Frontiers and MDPI journals to level 0. julkaisufoorumi.fi/en/news/chan...

Failures in Science - I just received a negative decision on a grant proposal—my fifth in a row. It’s a though streak but not the first one, and I just wanted to share. short 🧵👇

Will U.S. government scientists soon face the “muzzling” their Canadian counterparts experienced under right-wing Prime Minister Stephen Harper? David Shiffman spoke to several people whose work was affected by Harper’s regressive policies, and they have advice to help prepare for Trump 2.0. ⬇️

ubc.wd10.myworkdayjobs.com/en-US/ubcfac... We are looking for an imaging master to run a very cool shared microscope - Raman label-free, 2-photon, FLIM, high-res, fast capture, thick live tissue, organoids, high-content screening. We are a dynamic and supportive and fun environment.

Earlier this year, I received news that fake peer reviews were allegedly being submitted impersonating me and approximately six others I shared my story with Science to, hopefully, reduce the chance of this kind of breach happening again www.science.org/content/arti...

Very excited to present the structural and mechanistic basis for stress response silencing by the monster E3 ligase SIFI. www.biorxiv.org/content/10.1...

Congrats to Dane Sands in our lab for his Zymeworks Fellowships Award in Advanced Protein Therapeutics

Great quick read and a reminder that we first need to admit and accept our ignorance—that's what makes science so fun!

SAVE THE DATE 🗓️Ubiquitin & Friends Symposium: 8-9 May 2025 in Vienna! Registration will open🔜 Keep an eye out for the announcement 👀 ✨guest speaker lineup👇🧵 +talks from abstracts! Great chance for #ECRs to meet with peers & experts in a friendly setting! 🔗 www.protein-degradation.org/symposium/

This is real cool study showing how ubiquitin can recruit and activate a protease to eliminate a (DNA cross linked) protein … independently of the proteasome

🚀 Excited to announce that our Lab @UBC is recruiting! 🌟 We're looking for passionate intern, graduate, and postdoc with strong coding/ML backgrounds to join us in advancing AI for single-cell biology & brain-computer interfaces. 🏔️ Vancouver awaits! 👉 tanglab.msl.ubc.ca 📧 [email protected]

I love CAT tails (how cool is to have an RNA-independent pathway to synthesize polypeptides at the ribosome). Check out our preview article on a recent study from the Young-Jun Choe's lab written by @shriyakamat.bsky.social www.cell.com/molecular-ce...

agree!! I can only remember 1/2 of the acronyms on a good day, so when a sentence uses several of them, it simply become too cryptic I use a bold font each time I introduce an acronym to help distracted readers

I read that article last spring and I highly recommend it - even for non NIH applications!!!

Thanks to CNPN 2024 organizers, @philipplange.bsky.social and Mari De Marco, great sponsors, and all participants who made this conference happen🙌

Thanks for doing this!

Our lab sells them for 1/2 of the price in case you are interested

Shriya from our lab presented our work on temporal BioID at the @cnpn-org.bsky.social meeting today It’s a great feeling when trainees do a better job at presenting their work than we could have done 🤩

Sahil presenting some of his bioID work at the 2024 CNPN go #proteomics !

Ryan from our lab presenting his work @cnpn looking at yeast strains capable of producing more recombinant proteins. When we started doing #proteomics we actually found quite important differences between these strains More here www.biorxiv.org/content/10.1...

Snowflakes & Proteomics: the 2024 CNPN Fairmont fairytale… once upon a time there was a tiny single cell (Ljijana Pasa-Tolic), a mutated proteome (Matthew Berg from the Villen lab) and a nasty protease (Olivier Julien)…

Team work: making our new batch of competent cells (2.5 x 10^8) for next year of cloning