Mathieu Bourdenx (@mbourdenx.bsky.social)

Paper alert from the Duff Lab 🚨🚨 My amazing colleagues showed that, in novel MAPTKI models, hyperphosphorylation (in absence of aggregation or even seeding) is sufficient to drive synapse loss and cognitive deficits. Huge implications for preclinical research and the way to therapies. Have a read!!

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In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds - Nature Neuroscience Mice expressing humanized mutant tau exhibit synaptic loss and behavioral abnormalities in the absence of abnormal tau conformers, suggesting that hyperphosphorylated tau can be pathological, at least... https://www.nature.com/articles/s41593-024-01829-7