Coeurleophiles and autonomic fanatics, rejoice! I bring you a paper combining both. Here, we show that orthostatic hypotension must accounted for if attempting to utilize locus coeruleus integrity (with NM-MRI) in the DDx of #Parkinson's and #MultipleSystemAtrophy. link.springer.com/article/10.1...

Excited to share this comprehensive review on supine hypertension led by brilliant resident, Sally Zimmerman! @bidmcreseach.bsky.social @rueyhu.bsky.social @pbeach.bsky.social Supine hypertension and cardiovascular disease: controversies and advances www.tandfonline.com/doi/full/10....

Can you figure out the etiology of this patient's autonomic failure? www.neurology.org/doi/10.1212/...

Do YOU know the nuances of evaluating and managing cardiovascular autonomic failure in synucleinopathy patients? Check out this hot off the press review by my good friend Abhi Lenka and I, now published in @movedisorder.bsky.social's Clinical Practice journal. doi.org/10.1002/mdc3...

A quick update re NIH and NSF terminated grant tracking: Grant Watch has a new name! We're now called **Grant Witness** You can find us at grant-witness.us Please update your bookmarks and spread the word! 🙏 (And no, this wasn't our preference, but trademarks are a thing. 🤦‍♂️🤷‍♂️)

- Exenetide had promise as a disease modifying agent in #Parkinsonsdisease. How about #MSA? - Single center, *open-label* 48 wk trial lower change in UMSARS score over tme. - Treatment had no impact on objective findings. - Placebo/bias effects highly likely. onlinelibrary.wiley.com/doi/10.1002/...

I am 3 years out of formal training in movement disorders - a two year fellowship - and I only just heard a coherent rationale for why we refer to certain diagnoses as “essential.” Thanks to Bsky-less podcast from Practical Neurology.

The heartbeat evoked potential is modulated by fluctuations in blood pressure, as measured during paced breathing and postural changes. journals.physiology.org/doi/abs/10.1...

Chronic low thoracic epidural spinal cord stimulation may work in #Parkinsons with severe orthostatic hypotension. Previously, a different group showed its feasibility in a patient with multiple system atrophy. Many of us thought it may not work in PD. www.brainstimjrnl.com/article/S193...

Cerebellar #multiplesystematrophy #MSA & cognition. Huge number of patients (210). - 24.8% of patients had cognitive impairment on neuropsych tests of language, memory and processing speed - *NO* association with OH or HTN - ⬆️risk w/age, MRI hot-cross bun sign journals.sagepub.com/doi/full/10....

#interoception banger alert for new work by @mtsakiris.bsky.social and team. More evidence on how timing of cardiac phase (systole/diastole) impacts cognitive processes - facilitation of alerting. www.sciencedirect.com/science/arti...

Reduced REM sleep density in #Parkinsondisease linked to worse gait. CR levodopa at bedtime increased REM density! Very interesting. www.nature.com/articles/s41...

It’s a good thing Congress isn’t alive to see this

Very glad to share this *just* published viewpoint by myself, @abhilenka.bsky.social @spjuraschek.bsky.social @jeanieparkmdms.bsky.social and media-less Cameron in 'Clinical Autonomic Research' link.springer.com/article/10.1...

When Americans raised concerns about RFK Jr.'s anti-vaccine views, he said he was "not gonna take away vaccines from anybody." But now he's taking them away from millions of mommas and babies. Vaccine recommendations should be based on science, not RFK Jr.'s political agenda.

This is why B12 is always on the differential for autonomic failure. "Subacute Combined Degeneration Presenting With Prominent Autonomic Symptoms 12 Years After Total Gastrectomy: A Case Report" assets.cureus.com/uploads/case...

The excellent @vanderbilt.edu #autonomic team coming through with another great study demonstrating that post-prandial hypotension is more common/severe in autonomic failure due to a peripheral etiology. link.springer.com/article/10.1...

He's literally holding a red lightsaber.

‘Kennedy told reporters that there were "many, many good ways to treat measles and doctors need to know that and to know those methods.’ One problem; there is no treatment for measles. Signed, a doctor who’s been forced to deal with measles because of this stupid fraud.

No such thing as ‘validation’ of the 'neuronal α-synuclein disease integrated staging system' (NSD-ISS) for #Parkinsons. It uses αSyn-SAA positivity to anchor an “S-D-G” (Synuclein–Dopamine dysfunction–Genetics) model. Does it hold up? (1/4) movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

The science is clear: the more you listen to RFK, the stupider you get. Many scientists are saying this. #Trumpland #TrumpLies

Insightful combination of EEG and iEEG in a patient with epilepsy to study the effects of taVNS on heartbeat-evoked potentials (HEP) in the insula. taVNS enhanced HEPs, but the paper does not say the interaction (vs. sham) was not significant. #neuroskyence www.sciencedirect.com/science/arti...

Autism is not a disease and these kids are not damaged, despite what HHS Secretary Kennedy says.

As a biologist, I'm appalled at pride the White House takes in willful ignorance. In yesterday's executive order about NPR and PBS, their first example of "the trash that passes for `news' at NPR and PBS" is the statement that "banana slugs are hermaphrodites." But this is unequivocal fact.

Not disagreeing. This is a good piece. It offers some grounded and useful advice for how to advance free thought and good values in today’s autocratic America. But wow is it depressing. This is where we are at now. An autocratic America. Still, we will fight on together.

Global coordination of brain activity by the breathing cycle (new from Adriano Tort and colleagues) #neuroskyence 🧠🫁 www.nature.com/articles/s41...

Today is World Parkinson’s Day! 🌎 More than 10 million people worldwide are living with Parkinson’s disease. The Parkinson’s Foundation is dedicated to making life better for people with Parkinson’s disease by improving care and advancing research toward a cure. (1/2)

Do not normalize children dying from measles. Measles was previously eliminated in the US, thanks to vaccines. When children die from measles, it means that adults have catastrophically failed to protect them because they have rejected basic science.

RFK Jr. says that the “mistakes”made in mass firing HHS personnel was “always the plan”. It was always the plan to torture federal workers. It was always the plan to toy with scientists, to try to humiliate them. It was always the plan, said RFK Jr .

And The Director has the temerity to send out emails saying, “As we navigate these challenges, I will do my best to lead NIH through these reforms, implement new policies humanely, and endeavor to earn your trust.” Good luck with that.

From a source at NIH: “Right now NIH’s ability to buy things is dead. Nearly all people with the power to make an order — purchasing people — have been removed. The NIH hospital can’t buy medicines, the labs can’t buy petri dishes. X-Ray machine breaks? Too bad. Everything is stopped”

The NINDS scientists fired in the RIF are back at work - for now - after a "coding error" led to their accidental termination. HHS blames "broken systems left to us by the Biden administration." My story @science.org www.science.org/content/arti...

I’m putting together an NIH F31 app, retooling my DSPAN app stuck in limbo (bc it’s a diversity specialized neuro grant) My sponsors and I are scouring it for DEI. I’ve removed mention of my Latinidad to give it a shot And just got this msg from a cosponsor What a shameful reality #neuroskyence

Why is Trump going after US science? What's the endgame for these attacks? Vance, Rufo, Trump and Republican elites are attacking NIH and manipulating its grants in order to attack American universities. "It's bad, folks." New contributed post at our blog. Please share it w/ your 🧪 colleagues.

Dear scientists, We've heard from many of you: "What can I do to act, to help stop the authoritarian takeover? I feel helpless." One thing you can do is to get every scientist you know onto bluesky. Get them off Twitter. Talk to yr colleagues. Make it a point. Send this: bsky.app/starter-pac...

Busy day - check out our latest preprint, exploring domain specificity in cardiac and respiratory interoception!

So glad to share this pub after beginning it 3 years ago! Here, we provide a narrative overview on the case for impaired #interoception in #Parkinson disease: 1) Putative mechanisms 2) Literature evidence 3) Why it's important to study in PD 4) A framework for future study tinyurl.com/2yt65vn3

Bet you didn't know that vasovagal syncope could happen out of sleep! Raj and colleagues @ucalgary.bsky.social provide a systematic reivew: pmc.ncbi.nlm.nih.gov/articles/PMC...

I'm really excited to share these results! #neuroskyence #psychscisky

Truly awful. The intramural program supports so much exploratory work that happens basically nowhere else including my PhD. It’s a jewel that attracts scientists from all over the world to attempt their dream experiments. Please call your congress person about this if you can.

Functional #syncope (what the authors call non-syncopal fainting) is under-examined and shares interesting overlaps with #functionalseizures. Patients often go undiagnosed and may get many unnecessary studies and medications. Studies like this is sorely needed. link.springer.com/article/10.1...

A man genetically destined to develop early Alzheimer's… doesn’t. Why? A Nature study explores possible explanations: tau pathology limited to the occipital region, significant heat exposure, and a proteomic profile rich in heat shock proteins. Anything else? (1/4) 🔗 www.nature.com/articles/s41...

The AOA on top of it with a solution in search of a problem for neurology trainees.

Patient has PAF and mega-refractory OH. Patient gets low thoracic epidural stim for refractory OH while phenocoverting to MSA. Very interesting case. A cautionary tale for considering this in Parkinson's disease? link.springer.com/article/10.1...

Nice brief in the 'PPMI Scientific Update' on an article @jlucasmckay.bsky.social and I published last year in Autonomic Neuroscience on neurogenic OH in Parkinson's that used the PPMI. Article here: www.autonomicneuroscience.com/article/S156...

Thrilled to be talking about my favorite part of neurology at @aanmember.bsky.social 2025 annual meeting!

Probably a similar story for autonomic failure with neurogenic supine hypertension. Unfortunately, this is often ignored in patients with orthostatic hypotension. jamanetwork.com/journals/jam...

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Not sure how much this adds to questions about thermoception contribution to bodily awareness, specifically. Right hemispheric strokes have very well-known impacts on hemispatial and bodily awareness, generally. Interesting to see this extends to thermoception, though! www.nature.com/articles/s41...