Pirooz Zareie
@pzareie.bsky.social
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đź“Ą 29
đź“ť 3
Excited to share our review on the vital role of skin-resident T cells in protecting the body’s largest barrier organ. We explore their contributions to immune surveillance, tissue homeostasis, and skin disease. Check it out!
www.nature.com/articles/s41...
@danhkaplan.bsky.social
@LMackayLab
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Cutaneous T cell immunity - Nature Immunology
In this Review, the authors discuss the latest in skin immunology research with a special focus on the role of skin-resident T cells.
https://www.nature.com/articles/s41590-025-02145-3
6 months ago
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Check out our new paper!
add a skeleton here at some point
9 months ago
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reposted by
Pirooz Zareie
Seth Thomas Scanlon
9 months ago
Now in
#Science
#Immunology
: Justin Zhang, Jamie Rossjohn,
@pzareie.bsky.social
,
@niclag.bsky.social
, & al. generate LCK-FREE mice expressing mutated form of endogenous LCK that cannot bind to
#CD4
or
#CD8
. These animals show defects in
#TCell
lineage fidelity & antigen-specific
#TCR
diversity!
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LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity
LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses.
https://www.science.org/doi/10.1126/sciimmunol.adp5016
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