Our latest paper is out! We built a large-scale mutational map of amylin to understand how sequence drives #amyloid formation, a process linked to type 2 #diabetes🩸📈📉. It’s a step towards connecting molecular mechanisms with human genetic variation in a systematic way.

Dive in to see that RIPKs are quite the perfectionists: you need to nucleate just right - ni més, ni menys! 🎯

New cocktail 🍹 in town - in collaboration with @benlehner.bsky.social : Massive combinatorial mutagenesis + amyloid kinetics selection + thermodynamic modelling showing us the portrait 🎨 of an amyloid transition state. Read about it in this great thread:

Solving the many mysteries of amyloids 🧩🧬, next up at #VariantEffect25: @marianomartin.bsky.social from @bennibolo.bsky.social Lab presents: Deep mutagenesis reveals the interplay between RIPKs amyloid nucleation and protein activity

@juliadiumenge.bsky.social at #VariantEffect25

@mattcoelho.bsky.social at #VariantEffect25

VSS people are always hungry for more heatmaps discussion! (and burgers!) #VariantEffect25

@nickywhiffin.bsky.social at #VariantEffect25

🔬🗣 Warming up for the 8th Mutational Scanning Symposium with a satellite workshop at #IBEC on how to choose a model for variant interpretation and protein design Great line-up of speakers for an interactive quantitative biology session!