Taylor Mighell
@taylor-mighell.bsky.social
📤 92
📥 111
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Postdoc
@crg.eu
Barcelona GPCRs | synthetic biology | genomics
reposted by
Taylor Mighell
Atlas of Variant Effects Alliance
about 1 month ago
Tomorrow!
www.varianteffect.org/seminar-seri...
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reposted by
Taylor Mighell
Jingyou Rao
2 months ago
🎙️ Next up Dec 2 in VESS! Thea Schulze (Lindorff-Larsen Lab): Predicting mutated protein abundance
@tkschulze.bsky.social
Taylor Mighell (Lehner Lab): Massive mutagenesis to understand GPCRs
@taylor-mighell.bsky.social
🔗 More info at
varianteffect.org/seminar-series
@varianteffect.bsky.social
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reposted by
Taylor Mighell
Nature Structural & Molecular Biology
4 months ago
New online: A small molecule stabilizer rescues the surface expression of nearly all missense variants in a GPCR
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A small molecule stabilizer rescues the surface expression of nearly all missense variants in a GPCR
Nature Structural & Molecular Biology, Published online: 22 September 2025; doi:10.1038/s41594-025-01659-6Many mutations cause disease because they destabilize proteins. Here, Mighell and Lehner show that a single small molecule can correct the destabilization caused by nearly all pathogenic mutations in a human GPCR.
https://go.nature.com/427CpmV
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GPCR-MAPS is now live!
www.biorxiv.org/content/10.1...
A new platform for high resolution functional mapping of GPCRs with massive mutagenesis. We identify the core activation network, residues involved in biased signaling, and generate >7,000 full dose response curves. With
@benlehner.bsky.social
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The genetic architecture of G-protein coupled receptor signaling
G-protein coupled receptors (GPCRs) are the most abundant class of human receptors and drug targets. The vast majority of GPCR drugs bind the conserved orthosteric pocket, which can lead to non-specif...
https://www.biorxiv.org/content/10.1101/2025.05.30.656974v1
7 months ago
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reposted by
Taylor Mighell
bioRxiv SysBio
7 months ago
The genetic architecture of G-protein coupled receptor signaling
https://www.biorxiv.org/content/10.1101/2025.05.30.656974v1
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reposted by
Taylor Mighell
Jonathan Frazer
8 months ago
Another local hero! Up next at
#VariantEffect25
:
@taylor-mighell.bsky.social
from
@benlehner.bsky.social
lab presents: Two wrongs make a right: can GPCR antagonists rescue mutant receptors? 🧬🧪🔁
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reposted by
Taylor Mighell
Isabelle Zane
8 months ago
@taylor-mighell.bsky.social
at
#VariantEffect25
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reposted by
Taylor Mighell
Centre de Regulació Genòmica (CRG)
about 1 year ago
Introducing Human Domainome v1, the largest and most comprehensive library of human protein variants to date, which maps the effects of +500K mutations across 522 domains. The study by
@benlehner.bsky.social
and Toni Beltran is out now in
@nature.com
. Illustration by
@queralttolosa.bsky.social
.
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reposted by
Taylor Mighell
Ben Lehner
12 months ago
Nice highlighting of
@taylor-mighell.bsky.social
's GPCR pharmacochaperone preprint by
@dereklowe.bsky.social
@science.org
www.biorxiv.org/content/10.1...
add a skeleton here at some point
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reposted by
Taylor Mighell
Centre de Regulació Genòmica (CRG)
12 months ago
Missense mutations are responsible for many heritable genetic disorders. Researchers led by
@benlehner.bsky.social
are carrying out large-scale experiments to understand why. Unstable proteins are emerging as a clear mechanism of action. Today in
@elpais.com
by
@manuelansede.bsky.social
.
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The first ‘human domainome’ reveals the cause of a multitude of diseases
An ingenious large-scale experiment in Barcelona has led to the creation of a catalog detailing the effects of half a million DNA mutations
https://english.elpais.com/science-tech/2025-01-08/the-first-human-domainome-reveals-the-cause-of-a-multitude-of-diseases.html
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