Taylor Mighell (@taylor-mighell.bsky.social)

A small molecule stabilizer rescues the surface expression of nearly all missense variants in a GPCR Nature Structural & Molecular Biology, Published online: 22 September 2025; doi:10.1038/s41594-025-01659-6Many mutations cause disease because they destabilize proteins. Here, Mighell and Lehner show that a single small molecule can correct the destabilization caused by nearly all pathogenic mutations in a human GPCR. https://go.nature.com/427CpmV