🧵 1/8 🧪 TB research has long focused on a single pathogen: Mycobacterium tuberculosis. 🦠 But TB unfolds within a complex microbial ecosystem. The human microbiome may influence susceptibility, inflammation, and treatment outcomes. Our perspective ⬇️ 🔗 t.ly/jMK3R

Conexión MICROBIOMA presenta la infografía “Entender los test de microbioma: alcance y límites actuales”, un recurso divulgativo que explica qué analizan estas pruebas, cómo funcionan y sus limitaciones científicas y clínicas, recordando que no son diagnósticas y requieren asesoramiento profesional

💊 Las 3 veces que he comprado antibióticos en farmacias distintas me han ofrecido probióticos para “evitar complicaciones”. 📉 No hay evidencia sólida que respalde su uso sistemático en este contexto. 💰 Es un negocio lucrativo que no debería promoverse desde entornos sanitarios 🧪

1/10 🧵 Proud to share results from the INSTINCT trial, published in @cidjournal.bsky.social! A randomized study addressing a key question: Does TAF have independent effects on weight and inflammation in people with HIV? Spoiler: no 🧪 doi.org/10.1093/cid/...

El @csic.es difunde la concesión de la ayuda de proyectos sinérgicos de la Comunidad de Madrid a nuestro compañero Dr. Bruno Sainz junto con el Dr. Sergio Serrano-Villar @serranovillar.bsky.social del #IRYCIS Enhorabuena a los dos grupos de investigadores👏 @dicma-csic.bsky.social

“The Trump administration is, for the first time in history, substantially intervening inside NIH to bring it under political control,” according to a senior NIH official who spoke on condition of anonymity. My latest. www.theguardian.com/us-news/2025...

🧠 Lithium and Alzheimer’s A new study found that lithium protects the brain. In mice, early lithium loss triggered Alzheimer’s-like damage, but a special lithium salt reversed it. 🔗 www.nature.com/articles/s41... #SciComm #Alzheimers 🧪

📣Bruno Sainz from #IIBM @csic.es receives substantial funding in the call for synergistic projects (CAM), together with @serranovillar.bsky.social -Ramón y Cajal Hospital/IRYCIS ➡️Reprogramming The Tumor Microenvironment Through Microbiome-Derived Immunomodulatory Molecules Congratulations Bruno!!👏

🧬 Our new paper in TMAID: Chronic Chagas disease disrupts gut microbiome metabolism. 🔻 TCA, β-oxidation & haem pathways fall 🔺 Benznidazole partly restores microbial function 💡 Biomarkers & targets for microbiota therapies 📄 doi.org/10.1016/j.tm... 🙌@infecciosasryc.bsky.social #Chagas #Microbiome🧪

💥 #IAS2025 | #HIV Global Alert 💥 The abrupt US funding cuts are already hitting hard: 📉 Mozambique: 25% drop in ART initiations/month 📉 Johannesburg: 30% drop in testing, diagnoses & ART/year 🌍 Latin America & Caribbean: 87% of orgs lost funding

🧬 Gut-heart axis 2.0. 💥🦠 A gut-bacterial metabolite (imidazole propionate) doesn’t just correlate—it causes #atherosclerosis. 🔎 Mechanism: macrophage inflammasome activation via mitochondrial ROS. 🧪Pharmacologic inhibition reversed vascular inflammation in vivo. www.nature.com/articles/s41...

🚨 A gut bacterium, Hominenteromicrobium YB328, boosts PD-1 cancer immunotherapy by activating dendritic cells & T cells. 🧬 Precision microbiome meets precision medicine. Now heading to clinical trials 🧪 🔗 www.nature.com/articles/d41... We’re tracking this closely as part of our RUMBA study.

Took 4,800 years and a few stubborn molars, but we finally got the first full genome from ancient Egypt. Mummies: still better preserved than most backup hard drives.🧪🧟‍♀️ 🔗 www.nature.com/articles/d41...

Where do academics go when they leave for industry? The top 10 destinations are all tech giants—led by Google, Amazon, Meta & Microsoft. Pharma and biotech don’t even make the list. Fascinating shift in the R&D landscape. 🧪 🔗 www.nature.com/articles/d41...

The isolated hepatitis B core antibody: HBsAg ⛔ anti-HBs ⛔ anti-HBc ✅ What does it mean, and what should you do? A mystery solved (mostly). Plus, a poll and a couple of great videos. #IDSky blogs.jwatch.org/hiv-id-obser...

💥 Big news! We’ve secured €750K for the RUMBA project through the Synergistic Projects call. We’ll decode microbiota-derived molecules to boost immunotherapy in lung cancer. The microbiome takes the stage! 🦠🫁 🧪 #microbiome #immunotherapy #lungcancer

Como cada año, el taller de Sergio Serrano en #XXVIIICongresoSEIMC no se puede perder. Como convertir a la IA en tu asistente de investigación? (Si no usas la IA no pasa nada. Si la usas bien puede facilitar mucho el trabajo. Pero si la usas mal, una carrera científica puede terminarse)

More than twenty years ago, I was making coffee ☕ at PretaManger in London and learning the ropes on my first-ever salary. Today, I came back to speak 🎤 at the IANSociety meeting on #microbiome and #HPV. 🙏 Grateful to the organizers for bringing together such a vibrant community 🌱 t.ly/S3WyZ

Dr. Jaime Altchech, jefe de servicio de Parasitología, del Hospital de Buenos Aires y uno de los referentes en investigación en enfermedad de Chagas. 👶🏽 Su experiencia en Enf. de #Chagas congénita en nuestras sesiones monográficas. ¡Gracias por la clase magistral! 👏 #NeglectedDiseases

If anyone is looking for a true "start" of the effective ART era for HIV, I'd vote for Jan 1996 CROI, when 24 wk data from this study were presented for the first time. Indinavir joined ritonavir (🤮) and saquinavir (😑) with full FDA approval in March. So amazing. www.natap.org/1998/drug/03...

Un año más, estrechamos lazos con nuestr@s compañer@s de Microbiológia con el clásico nudo #SEIMC2025 🤝

🔬 Just out in #Microbiome: our consortium’s review highlights how #metaproteomics can reveal microbial effectors—like toxins, AMR proteins & phages—that shape microbiomes across human, animal & environmental health. A #OneHealth perspective 🌍🧫 🔗 t.ly/P-PWh #MicrobialEcology

🧵No os perdáis las novedades presentadas en seimc2025.org 📍#SEIMC2025 arranca con fuerza 💪 Aquí un hilo con nuestras aportaciones 👇

Caso clínico: 👩‍⚖️ ♀ 52 años natural de El Salvador con miocardiopatía periparto. Tx ❤️marzo 24. Estudio preTx Nov 2023 con serología + Trypanosoma cruzi (no revisada).

🎓Excelente revisión sobre terapia nebulizada en pacientes hematológicos. Dr. Jesús Fortún. ✅ En nuestro ensayo aleatorizado con ANF-B nebulizada en pfx de aspergilosis Invasiva observamos reducción de inflamación pulmonar por PET. shorturl.at/R4Avq ✅ La terapia nebulizada en pfx es prometedora

📣 Imperial College Research Fellowships! Prestigious 4yr fellowship ✔️ Salary from £48k ✔️ Up to £45k for research ✔️ A supportive, inclusive research environment ✔️ UK or international ✔️ <4 yrs post-PhD Drop me a pm if you are interested in bee/microbe related research! tinyurl.com/mr3k5a93

Very sensible take on Covid (and other infections) in kids for 2025.

Anyone who attended this year's #CROI2025 will tell you it was a very strange experience given the current political climate. Still, plenty of interesting studies -- here's a Really Rapid Review of selected highlights. #IDSky #HIVSky blogs.jwatch.org/hiv-id-obser...

Don't forget to come and chat to us about our poster on the diagnostic value of CT-guided biopsy for spondylodiscitis! #ESCMIDGlobal #IDSky #MedID @infecciosasryc.bsky.social

Great work lead by Aula Abbara and @martagonzalezsanz.bsky.social. Travel Med Infect Dis 2025 Epub Ahead Apr 2; www.sciencedirect.com/science/arti... #OneHealth #GlobalHealth #Syria #TravelMedicine #InfectiousDiseases #NeglectedTropicalDiseases #HumanitarianCrisis #ESCMID #ESGITM #ESGCP

Very excited to be at ESCMID Global 2025! Check out our work! #ESCMIDGlobal #MedSky #IDSky

Bringing the focus on Neglected Tropical Diseases: cystic echinococcosis #BeatNTDs #ESCMIDGlobal 2025 #MedSky #IDSky

Today at #CROI2025 we #standupforscience and talk about the benefits of HIV research

PEPFAR in a nutshell #CROI2025

Curiosamente, un joven que no se deja manipular por nadie defiende las mismas ideas que los tres hombres más ricos del mundo.

On this day in 1981, a landmark paper in NEJM described four patients with evidence of immunodeficiency associated with PJP pneumonia, disseminated CMV, and Kaposi sarcoma. The disease would come to be known as HIV/AIDS. Revisit the paper: nej.md/41iekKD #MedSky #IDSky

📢 We're hiring! Looking for a postdoc in bioinformatics/data analysis to join our team at Ramón y Cajal University Hospital, Madrid. 🧬 Focus: microbiome, diagnostics, and advanced therapies. More info here: t.ly/QQuD2 📅 Deadline: January 31st, 2025. Please share! #job #bioinformatics #microbiome

Freshly landed here, my first sci-bluesky-tutorial! We just published this study in #Microbiome 📢The microbiome is a potential therapeutic target to mitigate inflammation-related complications in people with #HIV 📜Article doi.org/10.1186/s401... 📺Video abstract youtube.com/watch?v=RxZe...