🧵 Essential ID Papers for 2025: A Clinician’s Guide Each year brings a flood of amazing ID literature. Here are candidates for some of the most important ID papers of 2025, spanning guidelines, trials, antimicrobials, and vaccines. 👇

Le ministre Dubé démissionne;

Trial of High-Dose Oral Rifampin in Adults with Tuberculous Meningitis Congratulations to David Meya, Fiona Cresswell, @natebahrid.bsky.social @drboulware.bsky.social & co on this important trial No mortality benefit to high dose rifampin in adults with TB meningitis www.nejm.org/doi/full/10....

🆕⚡🧠HARVEST TRIAL:More Rifampin,Same Fate: High-Dose Rifampin Fails to Shift the Needle in TB Meningitis,NEJM,2025 Despite better theoretical CNS penetration,high-dose oral rifampin did not improve survival in adult TB meningitis & potential harm cannot be excluded #idsky www.nejm.org/doi/full/10....

Et voilà ! On le dit depuis le début… et c’est la même chose pour les spécialistes Êtes-vous vraiment surpris que le ministère aurait pu se tromper dans ses calculs ? Non ! www.lapresse.ca/affaires/chr...

𝗕𝗮𝗰𝘁𝗲𝗰 𝗙𝗫 @ 𝗦𝘁-𝗝𝗲𝗿𝗼𝗺𝗲 New device for BC next monday! Main changes :  1. New bottles w/ thin cap 2. Finally enough space for 4 bottles/pt! Bacteremia detection ability expected to go up by ~ 5% 3. We’ll start to use diversion to reduce contamination rates by an expected 60% #IDSky #MicroSky

On World AIDS Day, remember that HIV risk often changes over time & that our prevention tools keep expanding. PrEP, PEP & PEP-in-Pocket ("PIP") offer strong, flexible protection. A "buffet" approach lets people choose what best fits their lives. tinyurl.com/2zkf3hak

Hepatitis B reactivation following switch away from tenofovir-containing anti-retroviral therapy in people living with HIV: A case series and lessons for practice 🔗 https://bit.ly/4pmCEDJ

Can we really be grateful for anything in the ID world in 2025? Sure -- plenty of great advances! Here are a half-dozen to celebrate (and be grateful for) in 2025, believe it or not. #idsky blogs.jwatch.org/hiv-id-obser...

Inspired by this rage-inducing ad, I offer 3 big misses on antibiotics that need to die. paulsaxmd.substack.com/p/three-myth...

Fascinating CID Brief Report ➡️Safe implementation of novel HBV-inactive cART for people living with HIV and prior HBV exposure is of paramount importance and better clinical trial and real-world data is essential to inform best practice

Fascinating CID Brief Report #HIVsky #IDsky « Hepatitis B reactivation following switch away from tenofovir-containing antiretroviral therapy in people living with HIV: A case series & lessons for practice» (Thank you @josephmarcusid.medsky.social for flagging it) academic.oup.com/cid/article/...

A great @cidjournal.bsky.social case series that led to lots of discussion with the fellows today- 4 🇬🇧 pts with HBV reactivation after change off of a TAF-based HIV regimen Pt1/4: +HBcAB, -HBVsAg, -HBVsAB Pt2/3: +HBcAB, -HBVsAg,+HBVsAB #IDSky academic.oup.com/cid/advance-...

🆕🔥🦴 Our 2025 Update to @wiki-guidelines.bsky.social for the Management of Pyogenic Osteomyelitis in Adults 🌟 @bradspellberg.bsky.social 🔗 [link] #idsky www.amjmed.com/article/S000...

Le président du CMDP, Michel L’Allier;« On travaille beaucoup avec des cancers, et nous, qu’est-ce qu’on fait quand il y a un cancer ? On l’enlève. Quand une loi n’est pas bonne et que c’est un cancer pour le système de santé, on l’enlève » #Loi2 = ⚠️ et 💩 www.lapresse.ca/actualites/s...

Je suis un médecin. Je ne quitterai pas le Québec. Je serai « ailleurs » dans ma tête. Tout simplement. Strict minimum. Zéro motivation. #JeMeSouviens #Loi2

Anal cancer screening: a balanced approach is necessary ✅ Just Accepted #IDTwitter 🔗 https://bit.ly/4oK9kra

❤️ @wrexhamafc.co.uk Back-to-Back-to-Back Racecourse ground #history

That’s a wrap ! Back home after my first « on site » @aasldnews.bsky.social Liver Meeting @ Washington DC It was my first non-HIV meeting (outside 🇨🇦) in ~ 10 years. Way overdue 👍 #TLM2025 p.s. The snow was waiting for me…

Tobevibart plus elebsiran and tobevibart alone both lowered HDV RNA and ALT levels. The combination resulted in a high incidence of undetectable HDV RNA and an HBsAg level below 10 IU/ml at week 48. Full SOLSTICE phase 2 trial results: nej.md/4qIXpuM @aasldnews.bsky.social | #TLM25

My eyes were bleeding 🩸 (🇮🇳 RCT, HCV, SOF/VEL 8w vs 12w)

Chess and pickelball #TLM2025 😅

« This is the water that I swim in » Powerful talk by Wendy Lo #TLM2025 #HBV @aasldnews.bsky.social

Selfie with @suwang88.bsky.social ✅ #HBV #TLM25 @aasldnews.bsky.social

Should I Worry About the Pasta? The ID Doctor as News Translator (Hello #IDSky and #Medsky! Trying out some different venues for writing, so hoping you'll subscribe -- it's free!) open.substack.com/pub/paulsaxm...

HBV siRNA vs ASO : in a nutshell #TLM2025 @aasldnews.bsky.social

HBV HCC screening @aasldnews.bsky.social 2025 guidelines #TLM2025

Washington DC @ #TLM2025 @aasldnews.bsky.social 🔥Hot Topics in Hepatitis B : New Clinical Tools for Hepatitis B Management (after my 10 km)

🆕🔥State-of-the-Art Review with 🌟s @trubianojason.bsky.social : Antibiotic Allergy—A Multidisciplinary Approach to Delabeling #idsky url: academic.oup.com/cid/article/...

@glaucomflecken.bsky.social hitting close to home with this ID doc at the soccer game.... Reflexively, I couldn't help screaming in my head...don't put DEET on the net, only use permethrin on clothing!! #IDSky www.youtube.com/shorts/Q8UGF...

🆕 AASLD/IDSA Practice Guideline on treatment of chronic Hepatitis B @aasldnews.bsky.social @idsainfo.bsky.social journals.lww.com/hep/abstract...

Loi 2 : CAQ(A)strophe 💩

Système de santé québécois « in a nutshell »

#Loi2 Legault persiste et signe ce PM en conférence de presse; «  Mais, il faut à un moment donné laisser la poussière retomber. » Ce nest pas de la poussière. C’est un tas de roches 🪨

#Loi2 💯 👇 www.lapresse.ca/actualites/c...

Loi 2 « Elle-même médecin, la fille de Lionel Carmant pourrait quitter le Québec » Et voilà! Quand même ton PÈRE ministre n’est pas capable d’expliquer les bienfaits de la Loi 2 et/ou de te convaincre.

De quoi parle les médecins spécialistes aujourd’hui ? - de la Loi 2 de 💩 - du DSQ de 💩 qui est toujours en panne et nous empêche de TRAVAILLER Votre réseau est brisé

Carrés Bleus #Loi2

RASSEMBLEMENT CITOYEN Samedi 1er novembre 2025 – 10h -Devant l’Assemblée nationale du Québec -Pour défendre notre santé, notre démocratie, notre avenir

Ladies and gentlemen, mesdames et messieurs; Loi 2 (Law 2) @ Québec, 🇨🇦

Mic Drop

Ministre @cdubesante.bsky.social ; beau mensonge sur la réduction $ de nos actes à TLMEP Allez relire votre loi.

#Loi106 💩 Lecture obligatoire

Quelle triste journée pour les soins de santé au Québec #Loi106

Vous pouvez bien rire comme vous voulez chers gens qui méprisent les médecins parce qu'ils font un maudit bon salaire. Cette Loi 106 va détruire nos soins. Pas l'améliorer. Mark my words. Bonne chance à tous 🤦‍♂️

Message de ma femme médecin spécialiste qui n’a JAMAIS manqué une journée de travail de sa vie malgré tout ça (incluant le jour de sa fausse couche… je m’en souviens comme si c’était hier 💔) Et je viens de démissionner de; -recherche clinique -médecin conseil santé publique Priorité loi 106 …. 🤮🤷‍♂️

🆕🔥🔥CloCeBa RCT Cloxacillin versus cefazolin for MSSA Bacteraemia Cefazolin has a non-inferior efficacy regarding mortality, microbiological or clinical endpoints and was associated with a lower rate of serious adverse events #IDSky www.thelancet.com/journals/lan...

What the DOTS trial of Staph bacteremia tells us: • Dalbavancin d1 and d8 vs daily IVs for WEEKS • No left-sided IE/CNS/prosthetics • Dalba not superior by DOOR endpoint, but similar clinical outcomes. Big implications for inpt care. More here! #IDSky tinyurl.com/3hjzkt96