Check out our latest publication on how to deliver #oncolyticviruses to the #centralnervoussystem, by using cells that have a natural capability to move into the brain crossing the blood brain barrier 🧪 www.sciencedirect.com/science/arti...

In hamsters, ##sarscov2 infects the brain stem chronically and triggers degenerative-like changes #longcovid @daniellebeckman.bsky.social @buonsenso.bsky.social @elisaperego78.bsky.social @longcovidadvoc.com @thecovidinfoguy.bsky.social @winslowsp.bsky.social pubmed.ncbi.nlm.nih.gov/40695836/

Grandissimo #Sinner

For those who are interested in #LongCovid #MECFS I have seen that an anti-CD19 antibody (depleting B lymphocytes) showed promise in treating the condition. Then wouldn't it be time to test anti-CD19 #CAR-T cells? They work very well against autoimmune diseases

Again, on monitoring #covid in #Austria, viral load is rising again and has doubled in a couple of weeks, especially in Vienna. Interestingly, they also monitor variants, but the most recent data is from middle May so maybe too early to see the new variant

Update: it seems that the Austrian #covid honeymoon might be over as the RNA load increases not dramatically, but steadily. Things might be on track to repeat the constant increase that was seen last summer @winslowsp.bsky.social @ryanhisner.bsky.social @elisaperego78.bsky.social

Genuine question for those actually interested in monitoring #covid.. I've been following wastewater data from Austria abwassermonitoring.at/dashboard/ . Why Austria? Well, because it's close to Italy and I can't find any data from Italy. Over the last 2 years it has been pretty standard

So many scientists are here on bluesky, so either you or someone you know could be interested in submitting a paper in this special issue of "Pharmaceutics" devoted to #oncolyticviruses as drug delivery platforms! (Where I serve as guest editor) 🧪 #medsky #sciencesky www.mdpi.com/journal/phar...

Se è vero (non ci si può mai fidare) si affacciano alcune domande: non era meglio semplicemente non cantarla? Più provocatoriamente se il "mood" del coro era questo, potevano cantare direttamente l'Horst-Wessel-Lied, che dava anche un tocco più internazionale.

"It's a cold" /s

Very important considerations on the persistence of SARS-CoV2 and how it can be associated with neurological symptoms.

Il paradosso di un paese che non ha gli occhi per piangere ma investe 25 miliardi in armi, e crea uno scudo aereo chiamato "lo scudo di Achille", scegliendo anche un eroe eponimo che notoriamente è finito ammazzato. E dire che ne avevano di possibilità mitologiche..

#sciencesky #science Has anyone else been wondering why some (very) outlandish stuff appears as trending articles on #pubmed? Is it the same for all? For example for me these days, the top trending article is a disturbing 1859 case report of rabies in a 10-yr old girl bitten by a polecat.

"Uno studio ha mostrato che la paura per l'AfD (estrema destra tedesca per chi non sapesse) è circa il doppio della paura dell'immigrazione. Nel documento preliminare Cdu-Spd per nuovo governo all'estremismo di destra non è dedicata neanche una parola, all'immigrazione due pagine"

The fact that in the absence of high vaccination rates measles makes a comeback, has nothing surprising at all. Here, multiple social factors are at work. Not all viruses are the same, for some viruses the immunity induced by current vaccines doesn't prevent infection but reduces severity/

@volksverpetzer.de Daraus habe ich jetzt erfahren, dass es nach @derstandard.at eine islamistische Terrorwelle in Österreich gibt.. Was denken Sie darüber?

If you want to sound cool and get general praise in international politics, just blame Europe. "Europe is shit" - almost nobody's going to be angry and you'll get a lot of nodding from Europeans themselves. The problem is that usually in the headlines they don't specify WHY Europe is so bad

"Negli ultimi giorni ci sono state aggressioni col coltello a Brema, Lubecca (...) diverse a Dortmund e a Berlino. In parte con morti, sparatorie con la polizia, vittime casuali. Probabilmente non hai sentito parlare di nessuno di questi casi" (gli aggressori erano tedeschi)

Un aspetto poco ricordato è che faceva parte dell'ideologia nazista l'oppressione a tutti i costi, l'idea che chi avesse abbandonato qualsiasi scrupolo, morale, diplomatico, politico, avrebbe vinto e dominato il mondo. L'esito è stata non solo la distruzione ma anche la auto-distruzione

I agree, it is becoming a great place to find scholars from different disciplines. I guess we'll have to cope with the reduced amount of anti-vaxx anti-science accounts.. We can make it 🧪

Lo dico? Che brutta fine che ha fatto la Svezia. La revoca della cittadinanza a me evoca sempre una parola tedesca: Ausbürgerung. Cercatela se volete ilpost.link/XgoZMz82VE

Just (re)sharing our latest work on #oncolyticviruses for #glioblastoma, in which we show a powerful immunogenic response to oncolytic HSV1 in an immunocompetent, orthotopic mouse model pubmed.ncbi.nlm.nih.gov/39334370/. Feel free to ask if you want to know more 🧪

The main issue with the current understanding of #sarscov2 is that everyone focused only on the acute infection. Both people and authorities became used to thinking that we have a problem with the virus when a lot of people end up in ICU with pneumonia./

A man who came back to Italy after travelling to #Congo has died of "fever with haemorrhage". Diagnostic investigations are ongoing www.quotidianosanita.it/m/regioni-e-...

This is the journal #science reminding us that #sarscov2 induces endothelial dysfunction, which can lead to problems in virtually any organ. Unfortunately, this can happen even if the primary infection is "mild", with an increased risk of vascular diseases like stroke, infarction/

I read that many people in the #US are (righteously) worried about a possible attempt of anti-vaxxers in the incoming administration to attack the #polio vaccine. Such phenomena require not just a scientific understanding, but also a lot of help from humanities

Now, suppose this had happened in another country, I have the feeling this piece of news would be more visible and there would be much more outrage..

For the new followers who are into #genetherapy, wouldn't it be nice to have viral vectors that can stably express much larger constructs than lentiviruses and AAV? Maybe even larger than adenoviruses?

Just came across a horrible article on an Italian newspaper claiming that the "cure" for #LongCovid was found www.huffingtonpost.it/salute/2024/... And the cure is.. psychotherapy and physical exercise. This is a misrepresentation of the study they are "quoting".

Un esempio di come NON fare giornalismo su temi medici. www.huffingtonpost.it/salute/2024/... Il #LongCovid è un problema di salute pesantissimo, sostanzialmente ignorato nonché il vero motivo per cui la pandemia non è finita. Ma questo articolo ci dà una notizia sensazionale: trovata la cura! /

Just a quick summary of my research activity.. if you've never heard about #oncolyticviruses (OVs for friends), they are viruses that can be used as anticancer drugs. How is that possible? Well, it turns out that among the many differences between malignant and normal cells/

La follia totale con le tinte della casuale normalità, come nei racconti di Kafka. Ci si prepara alla guerra! (Con la Russia). Ecco alcuni pratici consigli per sopravvivere 72 ore (come se fossero i consigli per la perfetta torta di mele o l'abbronzatura) www.lastampa.it/esteri/2024/....

The #h5n1 situation is that after spilling over to several mammalian species (seals, ferrets..) over years, the virus was established in livestock (cattle). In North America, increasing human infections are reported and for several of them the chain of transmission is unknown/

Considering moving my twitter activity here, let's see how it goes