Despite having been scooped big time by this paper from William Pastor's lab, really quite enjoyed reading it. Congrats to the authors.

Meet our team at the following events: 1️⃣ @keystonesymposia.bsky.social “Precision Genome Engineering”: Principal Scientist @jdfev.bsky.social will present a late-breaking talk “Engineering of Next Generation Epigenetic Editors for Enhanced Durable Repression in Non-Human Primates" (Tuesday 3/4)

Incredible resource for DNA binding protein specificity from the Codebook consortium. www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1... Am reading these in detail & will have a lot to say. Stay tuned for thoughts.

Epigenetics and chromatin crowd: What was a (or the) paper you read early on that made you think "wow, I'm in the right field". Mine is the classic on plant imprinting from Tetsuji Kakutani's group (Kinoshita et al., Science 2004) doi.org/10.1126/scie...

I've been meaning to write a lengthy thread about our experiences with DNA methylation editing in mouse ESCs if that would be useful (or interesting?) for a niche audience here. tl;dr: it was frustrating but we learned a lot, and it ended with our shiny new pub (1/17) www.nature.com/articles/s41...

Hey newcomers! You can find the folks you followed on Twitter with this tool (it’s imperfect but useful!) skeet.labnotes.org