Hiroyuki Yoshitomi
@hiro-yoshi-jpn.bsky.social
📤 25
đź“Ą 6
đź“ť 3
reposted by
Hiroyuki Yoshitomi
Nature Reviews Rheumatology
about 1 month ago
New content online:
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Two subsets of TPH cells with distinct functions in RA
Nature Reviews Rheumatology, Published online: 05 September 2025; doi:10.1038/s41584-025-01300-2Stem-like and effector-like peripheral helper T cells have distinct functions in rheumatoid arthritis.
https://bit.ly/4p8ZcIN
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đź“ŁOur new paper is out in Science Immunology. Yuki Masuo revealed two distinct subsets of peripheral helper T (Tph) cells in
#RheumatoidArthritis
.
@chimomonga.bsky.social
has nicely illustrated Tph-cell life.
doi.org/10.1126/scii...
@sciimmunology.bsky.social
@yuki-masuo.bsky.social
about 2 months ago
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Another publication in Science Immunology. We revealed that stem-like peripheral helper T (Tph) cells self-renew, proliferate, and sustain the pathogenesis of
#RheumatoidArthritis
in the synovium.
doi.org/10.1126/scii...
@sciimmunology.bsky.social
‪@ashbi-kyotou.bsky.social‬
@yuki-masuo.bsky.social
‬
about 2 months ago
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reposted by
Hiroyuki Yoshitomi
Saori Abe
2 months ago
www.science.org/doi/10.1126/...
“IGFL2 gene expression was specifically ⬆️ in
#TPH
cells in synovial tissue and fluid samples of patients with
#RA
. IGFL2 enhanced both TGF-β–induced production of CXCL13 by CD4 T cells and ⬆️ a shift in monocyte gene expression similar to pathogenic ones.”
#arthritis
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Human CD4+ T cells regulate peripheral immune responses in rheumatoid arthritis via insulin-like growth factor–like family member 2
IGFL2 is preferentially expressed by TPH cells and influences CD4+ T differentiation and macrophage activation in rheumatoid arthritis.
https://www.science.org/doi/10.1126/sciimmunol.adr3838
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reposted by
Hiroyuki Yoshitomi
Seth Thomas Scanlon
2 months ago
The August issue of
#Science
#Immunology
is out! This week: T peripheral helper cells expressing IGFL2 contribute to rheumatoid
#arthritis
; vagal TRPV1+ sensory
#neurons
protect against
#influenza
virus infection; & transfer of
#Tregs
alleviates
#inflammaging
in mice!
wwwscience.org/toc/sciimmun...
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reposted by
Hiroyuki Yoshitomi
Science X / Phys.org
2 months ago
A primate-specific cytokine, IGFL2, produced by helper T cells in rheumatoid arthritis joints, has been identified as a potential marker of disease activity and a target for new therapies.
doi.org/g9vwcj
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When immune commanders misfire: New insights into rheumatoid arthritis inflammation
Rheumatoid arthritis (RA) is a chronic autoimmune disease in which the immune system mistakenly attacks the lining of the joints (the synovium), causing pain, swelling, and progressive damage.
https://medicalxpress.com/news/2025-07-immune-misfire-insights-rheumatoid-arthritis.html?utm_source=bsky.app&utm_medium=social&utm_campaign=v2
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Our study on immune responses in synovial tissue of patients with rheumatoid arthritis reveals the involvement of an evolutionary novel cytokine IGFL2 in the pathogenesis.
@sciimmunology.bsky.social
doi.org/10.1126/scii...
loading . . .
Human CD4+ T cells regulate peripheral immune responses in rheumatoid arthritis via insulin-like growth factor–like family member 2
IGFL2 is preferentially expressed by TPH cells and influences CD4+ T differentiation and macrophage activation in rheumatoid arthritis.
https://doi.org/10.1126/sciimmunol.adr3838
2 months ago
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reposted by
Hiroyuki Yoshitomi
FOCIS - Federation of Clinical Immunology Societies
3 months ago
FOCIS also wants to congratulate the 2025 recipient of the British Society for Immunology (BSI) Poster Prize Award - Yuki Masuo, MD đź‘Ź
#FOCIS2025
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