🎉 Our new #mirobiome paper in #JHEP is out! We found distinct gut #virome shifts in #ACLF - from virulent to temperate #phages - with Lactococcus A + Enterococcus B phages linked to infections & higher 90-day mortality 👉 Read more: www.sciencedirect.com/science/arti... 📽️Video: youtu.be/0YF6qToBQUM

🌍 The MICROB-PREDICT team met in Münster, Germany from 1–2 October for its 14th Steering Committee Meeting! 👉 Team leaders discussed results from 20 new papers about late-stage #LiverDisease #cirrhosis #biomarkers and IPR topics as the project nears its final phase. The finish line is in sight!

20% live with #ChronicPain - many without effective treatment The QSPainRelief database uses published data, existing meds & advanced models to help design more effective therapies 🎥 Intro video: youtu.be/0VWoc2fqks8 🔗 Database: qspainrelief.lacdr.leidenuniv.nl #PainRelief #PersonalisedMedicine

👏 1st Site Visit Completed for A-TANGO's #ClinicalTrial: Thanks to big efforts by Yaqrit + Royal Free Hospital, we have kicked off our Phase 2a trial, evaluating the safety of #TLR4 antagonist in combination with #G-CSF for the treatment of #ACLF! #BenchToBedside #cirrhosis @rajivjalan.bsky.social

✨Final spotlight of this series: Our open access protocol on a self-medication #MouseModel of #ChronicPain that helps assess spontaneous #PainRelief & #DrugAbuse liability 🔗 doi.org/10.21769/Bio... Cabañero et al. (2022), co-authored by Beltrán Álvarez & Rafael Maldonado #Neuroscience #Analgesics

5️⃣ García-Blanco et al. (2002): www.jci.org/articles/vie... 📖 miRNA signatures associated with vulnerability to food addiction in mice & humans 💡Common #miRNA #signatures in mice & humans may underlie vulnerability to #FoodAddiction. 💡Targeting those miRNAs may modify maladaptive eating phenotypes.

4️⃣ academic.oup.com/ismej/articl... 📖 Presence of #Blastocystis in #GutMicrobiota associated with decreased executive function 💡Blastocystis colonisation in the gut is associated with measurable deficits in executive #CognitiveFunction, suggesting a possible #GutBrainAxis influence on cognition.

3️⃣ doi.org/10.3389/fpsy... 📖 Tetrahydrocannabinol #THC exposure in #adolescence elevates #impulsivity-like behaviour in #adulthood in a self-administration mouse model 💡Young-age THC exposure may produce a lasting impulsivity increase & neurochemical changes that predispose to #AddictiveBehaviour.

2️⃣García-Blanco et al., 2023 www.sciencedirect.com/science/arti... 📖 #CB2 #CannabinoidReceptor & the development of food addiction in mice 💡CB2R is a modulatory node in the control of hedonic feeding and vulnerability to #FoodAddiction, making it a potential therapeutic target for eating disorders

1️⃣ Del Mar Cajiao-Manrique, Maldonado & Martín-García (2023) doi.org/10.3389/fpha... 📖 A self-administration mouse model to study #CannabinoidAddiction 💡This novel #MouseModel provides a rigorous tool to study #CannabinoidAddiction & the neurobiological mechanisms of #vulnerability vs. #resilience.

🧬🐭👩‍🦰👨‍🦰 Translational research - from mice to humans - was central to #QSPainRelief: For better #PainRelief, safer #PainMedication and improved #ChronicPain treatment. ✅ Less pain 😵‍💫 Fewer side effects ☺️ Better QoL ✨ Here are 5 key papers about 🧠-mechanisms linked to #addiction #cognition #impulsivity

A more #PainRelief-relevant follow-up of the 2020 Sci. Rep. paper is this article by Ricarte, Dalton & Giraldo (2021), a year later: 🔗 doi.org/10.1021/acs.... 🧬 Structural assessment of #agonist #efficacy at the μ-opioid receptor #MOR 👉 #morphine and #fentanyl elicit different activation patterns

🔬 Wanna know the P-values for #agonist-dependent #GPCR activation? 👏 One of our 2 high-impact Nature publications was also the 1st QSPainRelief article: 📈 Bruzzese, Dalton & Giraldo (2020) present their #MolecularDynamics work & the best statistics to analyse it. 🔗 www.nature.com/articles/s41...

Here's another important QSPainRelief publication about allosteric sites at #GPCRs: They can be identified by looking at how strongly certain receptor sites are coupled to #conformational changes that occur during activation. 🔗 doi.org/10.3390/ijms... #allostery #pharmacology #receptors #ligands

Speaking of #allostery: What happens when you mutate the #CannabinoidReceptor (CB1) in silico with a single-point mutation? Find out👉: doi.org/10.1021/acso... Spoiler😉: The F237L mutation mimics #allosteric #ligand effects, globally altering #receptor conformations and hindering activation #GPCR

🎯Feature Alert 🚨 This paper delves into how #BindingKinetics reshape our understanding of #allosteric modulation. When it comes to cooperativity effects, it's all about 👉 WHERE molecules bind 👉 HOW FAST 👉 and in WHICH SEQUENCE 🔗 doi.org/10.1016/j.dr... #allostery #pharmacology #DrugDesign #GPCRs

🚀 Time-dependent #ligand-receptor #BindingKinetics and functionality in a #heterodimeric receptor model by Ortiz et al. (2024): Predicting how 2 drugs bind to a receptor complex over time - with implications for combination-therapies and #DrugDesign💊 🔗 doi.org/10.1016/j.bc... #Pharmacology #GPCRs

🔦 Spotlight on link.springer.com/article/10.1... 🧠 Using the LeiCNS-PK3.0 PBPK model, they predicted mouse #brainECF #pharmacokinetics for 10 drugs ✅ Accurate for 7 drugs ✅ First mechanistic #CNS PBPK #model in mice ✅ Strong translational potential #TranslationalPharmacology #DrugDevelopment

The paper by Budda et al. (2024) relates to the earlier publication by Gülave et al. (2023): doi.org/10.1016/j.ej... 🧠The transport of #morphine across the #BBB is non-linear - this is important for #receptor #occupancy predictions. Find out how BBB dynamics inform smarter, safer dosing strategies!

🧠 Non-linear blood-brain barrier #BBB transport & dosing influence #receptor #occupancy ratios of #morphine and #MorphineMetabolites (M3G + M6G) in the #pain matrix. 💡This might also explain some inter-individual differences! 🔗 bpspubs.onlinelibrary.wiley.com/doi/10.1111/... #ChronicPain #opioids

🔬By Bertayli et al (2024): PK-PD modelling of #morphine, #pregabalin & their combination shows synergistic #analgesia. Potential impact: 👉 Lowering #opioid doses 👉 Maintaining treatment efficacy 👉 Reducing side effects & abuse liability 🔗 www.page-meeting.org/default.asp?... #ChronicPain #Pain

📖 Just published 💊 👉 Introducing a rigorous theoretical framework for better #quantification of #drug-target #ResidenceTime (RT) - a key metric in #BindingKinetics that has lacked a firm quantitative foundation to date 👏 🔗 www.sciencedirect.com/science/arti... #Pharmacology #ComputationalBiology

🧪 Our new paper on the #pharmacokinetics of P-glycoprotein substrates in #brainECF shows how #invitro transport data can guide #invivo 🧠🐭🚶‍♀️predictions, but that high variability still limits the robustness of these predictions. 🔗 link.springer.com/article/10.1... 👉LeiCNS-PK3.4 PBPK model #CNS #brain

🫶 Our recent review shows that #SocialSupport is a powerful boost for #MentalHealth in #ChronicPain ⚡ , but its impact on pain intensity and daily function is less clear. 👉 Social support is crucial, but HOW matters 🔗 doi.org/10.1371/jour... #QoL #PainResearch #Pain @plosone.org @efic.bsky.social

🧠 Predicting how well #drug molecules cross the blood-brain barrier: Gülave et al. built a #MachineLearning model for the unbound brain-to-plasma partition coefficient (98 compounds). link.springer.com/article/10.1... 👉Best algorithm: Random Forest 💡Great for #CNS drug discovery! #BBB #PBPK #ML

💊 Morphine is a P-glycoprotein substrate, but do P-gp inhibitors meaningfully change #CNS exposure? 🧠 Likely not: A physiology-based pharmacokinetic #PBPK model predicts negligible impact across populations. #BBB #DrugInteractions #morphine #modelling #brain 🔗 link.springer.com/article/10.1...

Preoperative #susceptibility to secondary #hyperalgesia is associated with cough-evoked #pain 2 months after #thoracotomy (Gousset et al., 2025) 👉 onlinelibrary.wiley.com/doi/10.1002/... ⚕️Patients with high secondary hyperalgesia pre-op had more cough-evoked pain 2 months later. #PainPrediction

🧠 Central sensitisation drives #ChronicPain. This PhD thesis by Solenn Gousset (2025) bridges experimental pain models and clinical perspectives, exploring methods to measure and predict #CentralSensitisation. 👉 Explore the mechanisms behind persistent pain! 🔗 dial.uclouvain.be/pr/boreal/ob...

🧠 Ever wondered what affects how #morphine works in the brain? This modelling study found #beta-endorphin to be a major player in how morphine occupies its µ-opioid receptors (MORs) in rat #hypothalamus 🐭 #EndogenousOpioids matter, folks! #BindingKinetics #MOR www.sciencedirect.com/science/arti...

💡What happens when you combine 2 analgesics? 🔬 Bakker et al. (2025) used a nociceptive test battery to investigate #morphine + #pregabalin. Result: Increased #PainTolerance, only minimal side effects. A promising step toward safer #PainRelief & lower #opioid doses. pubs.acs.org/doi/10.1021/...

🔬 Read the original publication by Boglarka Balogh, David Tornai, Aniko Csillag et al. (2025) on behalf of the MICROB-PREDICT consortium and the PREDICT study group of the EASL-CLIF consortium: onlinelibrary.wiley.com/doi/10.1111/...

🚨 New #LiverFailure insights 🚨 In patients with #cirrhosis + acute #decompensation, secretory #IgA strongly correlates with #gut-barrier failure and is a powerful predictor of 90-day mortality in acute-on-chronic #LiverFailure #ACLF 👉 Watch on YouTube: youtu.be/KapUqG7AFFk #Biomarkers #GutBarrier

👏 ALB-TRIAL hits 50% enrollment 🎉 Half of the planned 240 patients have now been recruited across 14 centres in 7 countries - great progress for the MICROB-PREDICT project! Huge thanks to all site teams - Onward to full enrollment & better treatment for #cirrhosis patients with #ascites! #albumin

🎓 Dive into the complexity of #OpioidReceptors with Prof. Andrea Bedini (from @unibo.it) in his insightful Masterclass. 👉 A must-watch for anyone interested in #MOR, #KOR, and chronic pain therapeutics! ▶️ youtu.be/dcGBm03nvhI #GPCR #ChronicPain #Pharmacology @iasp.bsky.social @efic.bsky.social

For #WorldHepatitisDay we stand together 🩺 At A‑TANGO, we aim to transform healthcare for people with #LiverDisease, including those living with #cirrhosis and #ACLF, putting #patients first ☺️ Every person deserves timely, effective, and #stigma‑free support 💪 @europeliver.bsky.social @who.int

Good to see a feature on German TV last week about social prescribing, focusing in particular on museums and arts on prescription. This includes interviews with Wolfram from Charité and Nick from the National Academy for Social Prescribing, who are both part of SP-EU. www.3sat.de/kultur/kultu...

What an inspiring 9th Steering Committee Meeting! It was lovely to meet fellow liver-health enthusiasts & clinical investigators who recently joined the #GTAK Study. Let's include as many #ACLF patients in the study as possible.💉😊 #AlcoholicHepatitis @europeliver.bsky.social @easlnews.bsky.social

🆕 Our Annual Report is out now! It features the latest trends and achievements, from AI to climate change solutions, as well as the yearly monitoring of #HorizonEU. Explore the EU's Research & Innovation landscape in 2024. Read it here: europa.eu/!Nd6QPq

🌍 We’re bringing African & European researchers closer together under #HorizonEU. Scientists, innovators & experts from both continents will join forces to tackle shared regional & global challenges & advance the African Union - EU Innovation Agenda 🔗 europa.eu/!c4f3tx

We are delighted to say that our website is now live, with information and updates about the SP-EU programme and #SocialPrescribing social-prescribing.eu. Take a look and let us know what you think!

Join this exciting event! Don't miss our #OpenInnovation event, uniting experts in #DrugDevelopment, #bioinformatics, and #hepatology. Connect with researchers, industry professionals, and investors to share insights & explore collaboration opportunities! 🚀 Register now: inevent.uk/en/Crowdheli...

🧪 Day 2 Magic: 👉 Clinical efficacy, ethical considerations, and the final reporting 📰 👉 A power session on #dissemination, #IP, and how our #innovations will go commercial 🚀 👉 Brainstorming on next steps and funding pathways to keep our momentum going 💸 👉 Final wrap-up & virtual high-fives 🙌

🧠 Highlights from Day 1: 👉 Updates on our #QSPainRelief #ModelPlatform after a warm welcome by Liesbeth 👉 Deep dives into data management, in silico computations, cellular signalling, and preclinical validation 🔬 👉 Coffee-fueled discussions ☕ on how our model translates into real-world impact 💡

Wrapping things up for our final deliverables in fresh #SpringTime spirit: Our Steering Committee assembles for the last time as we shift into top-gear productivity 🚀until the end of June! 😎 #ChronicPain #PersonalisedMedicine #DrugCombinations #PainRelief @horizoneu.bsky.social @efic.bsky.social

We are delighted to be joining The International Social Prescribing Showcase on 16th June, hosted by The National Academy for Social Prescribing and The International Social Prescribing Collaborative. Sign up now socialprescribingacademy.org.uk/events/nasp-...

The European Citizens' Initiative has a petition calling for a ban on conversion practices for LGBTIQ people. Find out more: eci.ec.europa.eu/043/public/#...

It’s great to have SP-EU colleagues together here at Charité in Berlin for our first General Assembly!