🚀 Motivation boost to kick off the new year 🙂: The European Commission agreed to provide a 6-month-long extension to A-TANGO! Let's use this momentum and move forward swiftly now, so that A-TANGO can bring the much-needed G-TAK therapy for severe #AlcoholicHepatitis #cirrhosis #ACLF to the market.

🫖 Snuggle in with a cup of tea and a blanket over the holidays to read this year's MICROB-PREDICT publications - Wishing everyone relaxing winter holidays and a wonderful start into the New Year! ❄️ 📖 microb-predict.eu/for-scientis... @medblab.bsky.social @easlnews.bsky.social @ec.europa.eu

🥂 We have good news for the holidays: The technical hold-up in the EU portal has finally been resolved & we submitted the 3rd #PeriodicReport ☺️ Wishing everyone relaxing holidays❄️ Together, we are moving from bench to bedside to bring innovative therapies to #ACLF patients @rajivjalan.bsky.social

🚀 AF-B-STEP launches on 01 January 2026 🚀 🌐 afbstep.eu A global collaboration redefining atrial fibrillation (AF) - from “yes” or “no” to what really matters. We analyse data from 100,000+ people to quantify the global burden of AF - aiming to improve diagnosis, treatment and outcomes. #HeartHealth

As the year draws to a close, we are wrapping up 2025 with gratitude, momentum, and a spirit of community at concentris. ✨ 💡Curious about what’s next in 2026, and how these developments could support your work? Read our latest #newsletter: 🔗 mailchi.mp/concentris/n...

👉 In this video, Dávid Tornai (MD, PhD) from Maria Papp's group at the University of Debrecen in Hungary presents the consortium's research on serum #villin-1, a tell-tale sign of #GutBarrier failure in cirrhotic patients with acute #decompensation via a graphical abstract. 📽️ youtu.be/URerer6AxxY

👏 New study from Dávid Tornai and colleagues 🎉: Serum #Villin1 is a promising non-invasive marker of #GutBarrier damage in #cirrhosis and #ACLF. It rises with severity, predicts 90-day mortality, links to #inflammation, and has been validated in an independent cohort! 📜 doi.org/10.1111/apt....

📽️ Now online 🎧: lnkd.in/dJuMmsc4 Watch or listen to the newest EASL Studio Episode on “Rifaximin for Hepatic Encephalopathy: Balancing Benefits and Risks in the Era of Antimicrobial Resistance” from Wednesday, 26 Nov 2026. #rifaximin #HepaticEncephalopathy #AntimicrobialResistance #cirrhosis #ACLF

On Wednesday, 26 Nov, at 6 pm CET, EASL Studio hosts a new episode titled “Rifaximin for Hepatic Encephalopathy: Balancing Benefits and Risks in the Era of Antimicrobial Resistance” The episode will be broadcast live on EASL.eu and can be accessed here: 📹 easl.eu/easl-studio-... Don't miss it ☺️

🎉 Our new #mirobiome paper in #JHEP is out! We found distinct gut #virome shifts in #ACLF - from virulent to temperate #phages - with Lactococcus A + Enterococcus B phages linked to infections & higher 90-day mortality 👉 Read more: www.sciencedirect.com/science/arti... 📽️Video: youtu.be/0YF6qToBQUM

🌍 The MICROB-PREDICT team met in Münster, Germany from 1–2 October for its 14th Steering Committee Meeting! 👉 Team leaders discussed results from 20 new papers about late-stage #LiverDisease #cirrhosis #biomarkers and IPR topics as the project nears its final phase. The finish line is in sight!

20% live with #ChronicPain - many without effective treatment The QSPainRelief database uses published data, existing meds & advanced models to help design more effective therapies 🎥 Intro video: youtu.be/0VWoc2fqks8 🔗 Database: qspainrelief.lacdr.leidenuniv.nl #PainRelief #PersonalisedMedicine

👏 1st Site Visit Completed for A-TANGO's #ClinicalTrial: Thanks to big efforts by Yaqrit + Royal Free Hospital, we have kicked off our Phase 2a trial, evaluating the safety of #TLR4 antagonist in combination with #G-CSF for the treatment of #ACLF! #BenchToBedside #cirrhosis @rajivjalan.bsky.social

✨Final spotlight of this series: Our open access protocol on a self-medication #MouseModel of #ChronicPain that helps assess spontaneous #PainRelief & #DrugAbuse liability 🔗 doi.org/10.21769/Bio... Cabañero et al. (2022), co-authored by Beltrán Álvarez & Rafael Maldonado #Neuroscience #Analgesics

5️⃣ García-Blanco et al. (2002): www.jci.org/articles/vie... 📖 miRNA signatures associated with vulnerability to food addiction in mice & humans 💡Common #miRNA #signatures in mice & humans may underlie vulnerability to #FoodAddiction. 💡Targeting those miRNAs may modify maladaptive eating phenotypes.

4️⃣ academic.oup.com/ismej/articl... 📖 Presence of #Blastocystis in #GutMicrobiota associated with decreased executive function 💡Blastocystis colonisation in the gut is associated with measurable deficits in executive #CognitiveFunction, suggesting a possible #GutBrainAxis influence on cognition.

3️⃣ doi.org/10.3389/fpsy... 📖 Tetrahydrocannabinol #THC exposure in #adolescence elevates #impulsivity-like behaviour in #adulthood in a self-administration mouse model 💡Young-age THC exposure may produce a lasting impulsivity increase & neurochemical changes that predispose to #AddictiveBehaviour.

2️⃣García-Blanco et al., 2023 www.sciencedirect.com/science/arti... 📖 #CB2 #CannabinoidReceptor & the development of food addiction in mice 💡CB2R is a modulatory node in the control of hedonic feeding and vulnerability to #FoodAddiction, making it a potential therapeutic target for eating disorders

1️⃣ Del Mar Cajiao-Manrique, Maldonado & Martín-García (2023) doi.org/10.3389/fpha... 📖 A self-administration mouse model to study #CannabinoidAddiction 💡This novel #MouseModel provides a rigorous tool to study #CannabinoidAddiction & the neurobiological mechanisms of #vulnerability vs. #resilience.

🧬🐭👩‍🦰👨‍🦰 Translational research - from mice to humans - was central to #QSPainRelief: For better #PainRelief, safer #PainMedication and improved #ChronicPain treatment. ✅ Less pain 😵‍💫 Fewer side effects ☺️ Better QoL ✨ Here are 5 key papers about 🧠-mechanisms linked to #addiction #cognition #impulsivity

A more #PainRelief-relevant follow-up of the 2020 Sci. Rep. paper is this article by Ricarte, Dalton & Giraldo (2021), a year later: 🔗 doi.org/10.1021/acs.... 🧬 Structural assessment of #agonist #efficacy at the μ-opioid receptor #MOR 👉 #morphine and #fentanyl elicit different activation patterns

🔬 Wanna know the P-values for #agonist-dependent #GPCR activation? 👏 One of our 2 high-impact Nature publications was also the 1st QSPainRelief article: 📈 Bruzzese, Dalton & Giraldo (2020) present their #MolecularDynamics work & the best statistics to analyse it. 🔗 www.nature.com/articles/s41...

Here's another important QSPainRelief publication about allosteric sites at #GPCRs: They can be identified by looking at how strongly certain receptor sites are coupled to #conformational changes that occur during activation. 🔗 doi.org/10.3390/ijms... #allostery #pharmacology #receptors #ligands

Speaking of #allostery: What happens when you mutate the #CannabinoidReceptor (CB1) in silico with a single-point mutation? Find out👉: doi.org/10.1021/acso... Spoiler😉: The F237L mutation mimics #allosteric #ligand effects, globally altering #receptor conformations and hindering activation #GPCR

🎯Feature Alert 🚨 This paper delves into how #BindingKinetics reshape our understanding of #allosteric modulation. When it comes to cooperativity effects, it's all about 👉 WHERE molecules bind 👉 HOW FAST 👉 and in WHICH SEQUENCE 🔗 doi.org/10.1016/j.dr... #allostery #pharmacology #DrugDesign #GPCRs

🚀 Time-dependent #ligand-receptor #BindingKinetics and functionality in a #heterodimeric receptor model by Ortiz et al. (2024): Predicting how 2 drugs bind to a receptor complex over time - with implications for combination-therapies and #DrugDesign💊 🔗 doi.org/10.1016/j.bc... #Pharmacology #GPCRs

🔦 Spotlight on link.springer.com/article/10.1... 🧠 Using the LeiCNS-PK3.0 PBPK model, they predicted mouse #brainECF #pharmacokinetics for 10 drugs ✅ Accurate for 7 drugs ✅ First mechanistic #CNS PBPK #model in mice ✅ Strong translational potential #TranslationalPharmacology #DrugDevelopment

The paper by Budda et al. (2024) relates to the earlier publication by Gülave et al. (2023): doi.org/10.1016/j.ej... 🧠The transport of #morphine across the #BBB is non-linear - this is important for #receptor #occupancy predictions. Find out how BBB dynamics inform smarter, safer dosing strategies!

🧠 Non-linear blood-brain barrier #BBB transport & dosing influence #receptor #occupancy ratios of #morphine and #MorphineMetabolites (M3G + M6G) in the #pain matrix. 💡This might also explain some inter-individual differences! 🔗 bpspubs.onlinelibrary.wiley.com/doi/10.1111/... #ChronicPain #opioids

🔬By Bertayli et al (2024): PK-PD modelling of #morphine, #pregabalin & their combination shows synergistic #analgesia. Potential impact: 👉 Lowering #opioid doses 👉 Maintaining treatment efficacy 👉 Reducing side effects & abuse liability 🔗 www.page-meeting.org/default.asp?... #ChronicPain #Pain

📖 Just published 💊 👉 Introducing a rigorous theoretical framework for better #quantification of #drug-target #ResidenceTime (RT) - a key metric in #BindingKinetics that has lacked a firm quantitative foundation to date 👏 🔗 www.sciencedirect.com/science/arti... #Pharmacology #ComputationalBiology

🧪 Our new paper on the #pharmacokinetics of P-glycoprotein substrates in #brainECF shows how #invitro transport data can guide #invivo 🧠🐭🚶‍♀️predictions, but that high variability still limits the robustness of these predictions. 🔗 link.springer.com/article/10.1... 👉LeiCNS-PK3.4 PBPK model #CNS #brain

🫶 Our recent review shows that #SocialSupport is a powerful boost for #MentalHealth in #ChronicPain ⚡ , but its impact on pain intensity and daily function is less clear. 👉 Social support is crucial, but HOW matters 🔗 doi.org/10.1371/jour... #QoL #PainResearch #Pain @plosone.org @efic.bsky.social

🧠 Predicting how well #drug molecules cross the blood-brain barrier: Gülave et al. built a #MachineLearning model for the unbound brain-to-plasma partition coefficient (98 compounds). link.springer.com/article/10.1... 👉Best algorithm: Random Forest 💡Great for #CNS drug discovery! #BBB #PBPK #ML

💊 Morphine is a P-glycoprotein substrate, but do P-gp inhibitors meaningfully change #CNS exposure? 🧠 Likely not: A physiology-based pharmacokinetic #PBPK model predicts negligible impact across populations. #BBB #DrugInteractions #morphine #modelling #brain 🔗 link.springer.com/article/10.1...

Preoperative #susceptibility to secondary #hyperalgesia is associated with cough-evoked #pain 2 months after #thoracotomy (Gousset et al., 2025) 👉 onlinelibrary.wiley.com/doi/10.1002/... ⚕️Patients with high secondary hyperalgesia pre-op had more cough-evoked pain 2 months later. #PainPrediction

🧠 Central sensitisation drives #ChronicPain. This PhD thesis by Solenn Gousset (2025) bridges experimental pain models and clinical perspectives, exploring methods to measure and predict #CentralSensitisation. 👉 Explore the mechanisms behind persistent pain! 🔗 dial.uclouvain.be/pr/boreal/ob...

🧠 Ever wondered what affects how #morphine works in the brain? This modelling study found #beta-endorphin to be a major player in how morphine occupies its µ-opioid receptors (MORs) in rat #hypothalamus 🐭 #EndogenousOpioids matter, folks! #BindingKinetics #MOR www.sciencedirect.com/science/arti...

💡What happens when you combine 2 analgesics? 🔬 Bakker et al. (2025) used a nociceptive test battery to investigate #morphine + #pregabalin. Result: Increased #PainTolerance, only minimal side effects. A promising step toward safer #PainRelief & lower #opioid doses. pubs.acs.org/doi/10.1021/...

🔬 Read the original publication by Boglarka Balogh, David Tornai, Aniko Csillag et al. (2025) on behalf of the MICROB-PREDICT consortium and the PREDICT study group of the EASL-CLIF consortium: onlinelibrary.wiley.com/doi/10.1111/...

🚨 New #LiverFailure insights 🚨 In patients with #cirrhosis + acute #decompensation, secretory #IgA strongly correlates with #gut-barrier failure and is a powerful predictor of 90-day mortality in acute-on-chronic #LiverFailure #ACLF 👉 Watch on YouTube: youtu.be/KapUqG7AFFk #Biomarkers #GutBarrier

👏 ALB-TRIAL hits 50% enrollment 🎉 Half of the planned 240 patients have now been recruited across 14 centres in 7 countries - great progress for the MICROB-PREDICT project! Huge thanks to all site teams - Onward to full enrollment & better treatment for #cirrhosis patients with #ascites! #albumin

🎓 Dive into the complexity of #OpioidReceptors with Prof. Andrea Bedini (from @unibo.it) in his insightful Masterclass. 👉 A must-watch for anyone interested in #MOR, #KOR, and chronic pain therapeutics! ▶️ youtu.be/dcGBm03nvhI #GPCR #ChronicPain #Pharmacology @iasp.bsky.social @efic.bsky.social

For #WorldHepatitisDay we stand together 🩺 At A‑TANGO, we aim to transform healthcare for people with #LiverDisease, including those living with #cirrhosis and #ACLF, putting #patients first ☺️ Every person deserves timely, effective, and #stigma‑free support 💪 @europeliver.bsky.social @who.int

Good to see a feature on German TV last week about social prescribing, focusing in particular on museums and arts on prescription. This includes interviews with Wolfram from Charité and Nick from the National Academy for Social Prescribing, who are both part of SP-EU. www.3sat.de/kultur/kultu...

What an inspiring 9th Steering Committee Meeting! It was lovely to meet fellow liver-health enthusiasts & clinical investigators who recently joined the #GTAK Study. Let's include as many #ACLF patients in the study as possible.💉😊 #AlcoholicHepatitis @europeliver.bsky.social @easlnews.bsky.social

🆕 Our Annual Report is out now! It features the latest trends and achievements, from AI to climate change solutions, as well as the yearly monitoring of #HorizonEU. Explore the EU's Research & Innovation landscape in 2024. Read it here: europa.eu/!Nd6QPq