1/ Really neat case I helped with on my inpatient hematology rotation at @pennmedicine.bsky.social. Won't say too much to avoid spoilers, but definitely a head scratcher. Thank you to everybody who helped care for her and also Dr. Caren Solomon and @nejm.org for a constructive revision process!

Excited and grateful that our initial report on temperature-sensitive protein switches is now published @naturemethods.bsky.social Co-led by PhD students Will Benman and @dennishuang.bsky.social www.nature.com/articles/s41... Brief thread:

Super excited to share our new study from the @jbuenrostro.bsky.social Lab in @nature.com! We developed a computational method for tracking transcription factor and nucleosome binding using single-cell ATAC-seq and deep learning. Paper: www.nature.com/articles/s41...

Apparently cancer cells can pass defective mitochondria, effectively a metabolic poison, onto T cells as a mechanism of immune evasion. Who knew! Importantly, specific mtDNA mutations also predict poor clinical response to immune checkpoint inhibitors. www.nature.com/articles/s41...

Just saw Ricardo Mallarino present his lab's innovative work on uncovering the molecular mechanisms of developmental programs driving biological diversity in a number of nonconventional model organisms. This study in particular in sugar gliders blew my mind! www.nature.com/articles/s41...

We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵 www.biorxiv.org/content/10.1...

Excited to share James Jusuf's preprint: By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%) We quantify mESC 36k loops: <loops> are generally rare (2.3%) www.biorxiv.org/content/10.1...