Hopes that anti-#tau drugs could join those targeting #amyloid as treatments for #Alzheimers disease have been dented by the failure of a phase 2b trial of #JohnsonandJohnson's posdinemab.

An excellent review of Abeta seeds by my current and former students and postdocs. Abeta seeds are becoming increasingly important as immunotherapy moves towards presymptomatic stages. doi.org/10.1111/jnc....

My choice this week in @science.org www.nature.com/articles/s41...

I'm curious to know if the microglia repopulation would also work via blood. - Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders | Science Translational Medicine www.science.org/doi/10.1126/...

Long-term full amyloid removal potentially delayed symptom onset and dementia progression! Findings from the DIAN study. sciencedirect.com/science/arti...

Join us for a Master's in Neuroscience in Tübingen, Germany. www.neuroschool-tuebingen.de/application/...

Great summary of the history of early growth hormone preparations and their link to iatrogenic CJD and Alzheimer. Unfolding story of protein mis-folding causing Alzheimer’s disease in recipients of human pituitary growth hormone. , doi.org/10.1210/jend...

One more day to apply for these neurodegeneration professorships!

Dear Donald Trump: A letter from Nature on how to make science thrive and why it matters for the health, prosperity and safety of people of America and the world 🧪 www.nature.com/articles/d41...

amazing! doi.org/10.1038/s415...

Two flagship chair professorships for neurodgenerative diseases in Tübingen, Germany. Both affiliated with our university @hih-tuebingen.bsky.social and the German Center for Neurodegenerative diseases @dzne.science. Apply and join us! www.nature.com/naturecareer... www.nature.com/naturecareer...

What a cool read and quiz about confidence! Why probability probably doesn’t exist (but it is useful to act like it does)https://www.nature.com/articles/d41586-024-04096-5

Two flagship chair professorships for neurodgenerative diseases in Tübingen, Germany. Both affiliated with our university @hih-tuebingen.bsky.social and the German Center for Neurodegenerative diseases @dzne.science. Apply and join us! www.nature.com/naturecareer... www.nature.com/naturecareer...

Now that #lecanemab (#Leqembi) has been approved in Europe, we have updated our #Alzheimer game! Play and find out when is the best time to start immunotherapy. Play at --> hih-tuebingen.de/alzheimer/game

Trajectories of neurofilament light chain (a presumed marker of neurodegeneration) in CSF and blood over the entire course of (autosomal dominant) #Alzheimer's. doi.org/10.1038/s414.... Great collaboration with Dominantly Inherited Alzheimer Network (DIAN) @dzne.science @hih-tuebingen.bsky.social