New paper out: Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation.: Fricke, Michel; Mechel, Anna; Evers, Lennart; et al. Cell reports Vol. 45, no. 6, p. 117364 - | Thanks for sharing #dzne #papers

New paper out: Differential cholinergic white matter microstructural alterations in multiple system atrophy and Parkinson's disease.: Rong, Siming; Yang, Rui; Li, Zihao; et al. Neurobiology of disease Vol. 225, p. 107449 - | Thanks for sharing #dzne #papers

New paper out: The split homunculus: How in vivo brain parcellation provides new perspectives on brain health.: Kuehn, Esther Cortex Vol. 201, p. 94 - 103 | Thanks for sharing #dzne #papers

Smartphone-based memory tests can detect cognitive decline earlier than standard clinic assessments. DZNE researchers and international partners show that frequent remote testing captures subtle memory changes, enabling earlier detection and monitoring of AD. 👉 www.dzne.de/en/news/pres...

🎉 Congratulations to Prof. Dietmar Schmitz on receiving the 2026 FKNE Mentoring Prize! A well-deserved recognition of his outstanding commitment to mentoring and supporting the next generation of neuroscientists. 👉 www.dzne.de/en/im-fokus/...

New paper out: Genome‐Wide Assessment Reveals Ancestral Differences in Homozygosity Patterns Potentially Linked to Parkinson's Disease Etiology: Step, Kathryn; Hernández, Carlos F.; Khani, Marzieh; et al. Movement disorders Vol. 41, no. 5, p. 1128 - 1140 | Thanks for sharing #dzne #papers

New paper out: Linking combined oral contraceptive use to systemic immune marker profiles: the role of cortisol.: Klinger-König, Johanna; van der Auwera, Sandra; Töpfer, Philipp; et al. Frontiers in endocrinology Vol. 17, p. 1796526 | Thanks for sharing #dzne #papers

New paper out: Feasibility and Tolerability of Ketogenic Interventions in Amyotrophic Lateral Sclerosis-A Dose-Finding Case Series.: Herrmann, Christine; Satari, Samantha; Weber, Andrea; et al. Nutrients Vol. 18, no. 10, p. 1628 - | Thanks for sharing #dzne #papers

New paper out: Tracking of Neuroinflammation Dynamics During Combined Anti-β-Amyloid Therapy (AAT) and Immunomodulation in a Preclinical Alzheimer's Disease Model.: Wind, Karin; Kunze, Lea H; Willem, Michael; et al. International journal of molecular sciences Vol.… | Thanks for sharing #dzne #papers

New paper out: Stem-Cell-Derived Biologic Ventricular Assist Tissue in Heart Failure.: Zimmermann, Wolfram-Hubertus; Ensminger, Stephan; Kutschka, Ingo; et al. The New England journal of medicine Vol. 394, no. 20, p. 1991 - 2001 | Thanks for sharing #dzne #papers

New paper out: Gene deletion of Klotho in the dentate gyrus does not affect the number of adult-born granule cells.: Kraus, Patrick; Marunde, Monika; Ryzynski, Alexandre; et al. Scientific reports Vol. 16, no. 1, p. 16415 | Thanks for sharing #dzne #papers

🚨📢 New paper from the lab: Age-dependent vulnerability to spatial memory interference in APP/PS1 mice (a preclinical model of Alzheimer's disease) 🧵1/6 www.frontiersin.org/journals/agi...

DZNE Participates in New Collaborative Research Center in Bonn. “Rhineland Study” investigates impact of dietary diversity on health. 👉 dzne.de/en/im-fokus/meldungen/2026/dzne-participates-in-new-collaborative-research-center-in-bonn/

New paper out: AI software as a third reader in breast cancer screening-a prospective diagnostic observational study.: Lehnen, Thomas; Polenske, Doris; Wichtmann, Barbara Daria; et al. European radiology Vol. 36, no. 6, p. 4478 - 4488 | Thanks for sharing #dzne #papers

New paper out: Plasma levels of an N‐terminal tau fragment predict Alzheimer's and neurodegenerative disease biomarkers in autosomal dominant Alzheimer's disease: Schultz, Stephanie A.; Rao, Yiwen; Liu, Lei; et al. Alzheimer's and dementia Vol. 22, no. 1, p. e71049 | Thanks for sharing #dzne #papers

New paper out: Sphingolipidoses: expanding the spectrum of α-synucleinopathies.: Erskine, Daniel; Bronowska, Agnieszka K; Outeiro, Tiago F; et al. Journal of neural transmission Vol. 133, no. 5, p. 809 - 821 | Thanks for sharing #dzne #papers

New paper out: The PET tracer [11C]MODAG-005 targets alpha-synuclein aggregates in the brain.: Saw, Ran Sing; Haas, Sabrina; Schmidt, Felix; et al. Science translational medicine Vol. 18, no. 851, p. eaec0813 | Thanks for sharing #dzne #papers

New paper out: Characterization of the electrode-tissue interface during long-term deep brain stimulation in the 6-OHDA rat model of Parkinson's disease.: Philipp Payonk, Jan; Kober, Maria; Budde-Sagert, Kai; et al. Journal of neural engineering Vol. 23, no. 3, p.… | Thanks for sharing #dzne #papers

New paper out: Associations of the Lifestyle for Brain Health (LIBRA) index with cognitive functioning across adulthood: Variation by sex and socioeconomic status in the German National Cohort (NAKO).: Röhr, Susanne; Wittmann, Felix; Luppa, Melanie; et al.… | Thanks for sharing #dzne #papers

New paper out: Speech-based digital cognitive assessment for clinical trials: Detecting cognitive impairment stages and AD biomarker relations across European cohorts.: König, Alexandra; Tröger, Johannes; Mallick, Elisa; et al. Alzheimer's and dementia Vol. 22,… | Thanks for sharing #dzne #papers

New paper out: Evaluation of fully automated ApoE4 proteotyping for APOE ε4 genotype estimation in the FINDERI cohort.: Klafki, Hans-Wolfgang; Derad, Carlotta; Hoberg, Maike; et al. Alzheimer's & dementia / Diagnosis, assessment & disease monitoring Vol. 18, no.… | Thanks for sharing #dzne #papers

New paper out: Cellular and subcellular heterogeneity of astrocytic Na⁺ homeostasis tuning astrocytes into functionally distinct subgroups in the mouse brain.: Meyer, Jan; Bornemann, Viola; Bhattarai, Alok; et al. Nature Communications Vol. 17, no. 1, p. 4515 | Thanks for sharing #dzne #papers

New paper out: Benutzerhandbuch für die deutschsprachige QUALIDEM Version 2.0: Dichter, Martin; Ettema, Teake P.; Schwab, Christian; et al.   | Thanks for sharing #dzne #papers

Nature wants to hear from researchers around the world about what it feels like to work in science today. Are you burnt out? Excited about AI? Optimistic about your future in science — or not? go.nature.com/43AnCRU

Bei #Alzheimer ist ein bestimmter Bereich im Gehirn besonders früh von Veränderungen betroffen: der so genannte Locus Coeruleus. Dr. Lars Paeger vom @dzne.science erforscht, warum das so ist und was passiert, wenn die Energieversorgung in den Nervenzellen gestört ist. ▶️Mehr Infos gibt's im Video

New paper out: PinkyCaMP: an mScarlet-based calcium sensor with enhanced brightness, photostability and multiplexing capabilities.: Fink, Ryan; Imai, Shosei; Gockel, Nala Eileen; et al. Nature methods Vol. 23, no. 5, p. 998 - 1010 | Thanks for sharing #dzne #papers

New paper out: The In Vivo Microstructural Profile of Human Hippocampal Subfield CA1 and Its Relation to Memory Performance.: Hayek, Dayana; Höpker-Fernandes, Joseph; Vockert, Niklas; et al. Human brain mapping Vol. 47, no. 7, p. e70542 | Thanks for sharing #dzne #papers

New paper out: Arbeitsbedingungen von beruflich Pflegenden und deren Folgen, Teil 3: Schmidt, Sascha G.; Dichter, Martin; Hasselhorn, Hans M. Lebenswelt Heim  | Thanks for sharing #dzne #papers

New paper out: DNA methylation signatures of bilateral hippocampal volume, asymmetry and atrophy: a cross-omics analysis in the general population.: Liu, Dan; Talevi, Valentina; Tavares, Juliana F; et al. EBioMedicine Vol. 128, p. 106289 - | Thanks for sharing #dzne #papers

New paper out: New evidence on the clinical, genetic, and biochemical bases of GBA1-Parkinson's disease: prospects for treatment.: Menozzi, Elisa; Toffoli, Marco; Deleidi, Michela; et al. The lancet Vol. 25, no. 6, p. 602 - 614 | Thanks for sharing #dzne #papers

New paper out: IgLON5 autoimmune antibodies activate Tau via neuronal hyperactivity.: Askin, Bilge; Kilic, Cagla; Cordero Gómez, César; et al. Science advances Vol. 12, no. 20, p. eaec2042 | Thanks for sharing #dzne #papers

New paper out: Phenotypic spectrum of FGF14-related late-onset ataxia: predominant tremor and cognitive decline as key features of SCA27A.: Möller, Meret; Fienemann, André; Trinh, Joanne; et al. Journal of neurology Vol. 273, no. 6, p. 309 | Thanks for sharing #dzne #papers

New paper out: APTw CEST MRI in therapy-naive IDH-wildtype glioblastoma: insights into tumor heterogeneity and molecular subtypes.: Zeyen, Thomas; Decker, Andreas; Krause, Inga; et al. Journal of neuro-oncology Vol. 178, no. 1, p. 9 | Thanks for sharing #dzne #papers

New paper out: Potential proteomic biomarkers for monitoring clinical studies in Duchenne/Becker muscular dystrophy.: Dowling, Paul; Bouragba, Dounia; Negroni, Elisa; et al. Expert review of proteomics Vol. 23, no. 4-5, p. 109 - 120 | Thanks for sharing #dzne #papers

New paper out: Minor neuropsychological deficits and stage 2 of Alzheimer's disease.: Stark, Melina; Wagner, Michael; Kuhn, Elizabeth; et al. Alzheimer's and dementia Vol. 22, no. 5, p. e71458 | Thanks for sharing #dzne #papers

Neural networks are key to brain 🧠 function - influencing memory, aging, and neurodegeneration. With the new “Neural Networks Program”, 15+ DZNE research groups are joining forces to link network activity to disease and drive development of biomarkers and therapies. 👉 www.dzne.de/forschung/pr...

🧠✨ Experience neuroscience in action with the iBehave Network at Wissenschaftsnacht Bonn 2026 on May 21–22! Visit us at the TRA Life & Health tents @unibonn.bsky.social @rwth.bsky.social @fz-juelich.de @dzne.science @mpinb.mpg.de UKB & UOC #BoWiNa26 #Neuroscience #AI #outreach #publictalk #Bonn

DZNE researchers have generated new insights 🔎 into how the human genome 🧬 shapes the chemical composition and concentration of blood lipids. Their findings may help improve understanding of aging and disease. 👉 www.dzne.de/en/im-fokus/...

Researchers at DZNE and Charité unravel effects of autoimmune antibodies in “IgLON5 Encephalitis” and see similarities to #Alzheimer’s disease 🧠mechanisms. 👉www.science.org/doi/10.1126/...

New paper out: Dataset: A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model. Kreye et al, v1: Kreye, Jakob; Reincke, Momsen; Kornau, Hans-Christian; et al.   | Thanks for sharing #dzne #papers

New paper out: Dataset: PNN unit analysis, v1: Dityatev, Alexander; Dityatev, Alexander   | Thanks for sharing #dzne #papers

New paper out: Dataset: Early IFN-a signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19, v2: Kraemer, Benjamin; Schultze, Joachim L.; Krämer, Benjamin; et al.   | Thanks for sharing #dzne #papers

New paper out: Dataset: Data and statistical analysis for research article on Deficiency in MT5-MMP Supports Branching of Human iPSCs-Derived Neurons and Reduces Expression of GLAST/S100 in iPSCs-Derived Astrocytes published in Cells by Arnst et al. (2021), v1:… | Thanks for sharing #dzne #papers

New paper out: Dataset: Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells. Reincke et al, v1: Reincke, Momsen; Von Wardenburg, Niels; Homeyer, Marie; et al.   | Thanks for sharing #dzne #papers

New paper out: Dataset: Validity and value of metabolic connectivity in mouse models of β-amyloid and tauopathy, v2: Ruch, Francois; Ruch, Francois   | Thanks for sharing #dzne #papers

New paper out: Dataset: Discovering unifying disease recovery dynamics in COVID-19. Frishberg et al., v1: Frishberg, Amit; Shen-Orr, Shai; Frishberg, Amit; et al.   | Thanks for sharing #dzne #papers

New paper out: Data from: Microglial motility is modulated by neuronal activity and correlates with dendritic spine plasticity in the hippocampus of awake mice: Nebeling, Felix; Fuhrmann, Martin; Diseases, German Center for Neurodegenerative   | Thanks for sharing #dzne #papers

New paper out: Dataset: Data from: A human iPSC model of tauopathies engineered for 4R tau isoform expression endogenously develops late-stage neuronal tau pathology: Dannert, Angelika; Schulz, Nathalie; Klimmt, Julien; et al.   | Thanks for sharing #dzne #papers

New paper out: Dataset: Supplemental Material, Marchetti Giovanni and Gaia Tavosanis, Manuscript submitted to Current Biology, 2017, v3: Marchetti, Giovanni; Tavosanis, Gaia   | Thanks for sharing #dzne #papers

New paper out: Dataset: Supplementary Figures Tabular Data - The mitochondrial unfolded protein response disrupts neuronal–glial communication and promotes senescence in human microglia (v2): Pérez-Jiménez, María José; Bertoli, Federico; Weissleder, Christin; et… | Thanks for sharing #dzne #papers