Ralph Neumüller
@ralphneumueller.bsky.social
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📥 145
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Scientist/Wissenschaftler Science-Fiction Autor Musician
https://www.ralphneumueller.at/
reposted by
Ralph Neumüller
3 days ago
Our new preprint on DUSP4 in cancer is out. In vivo ARTi studies show DUSP4 loss doesn’t cause tumor regression and triggers fast compensatory reactivation. These results challenge DUSP4 as a monotherapy target. Link to preprint:
www.biorxiv.org/content/10.6...
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DUSP4 knockdown in BRAF V600E mutant colorectal cancer induces cell cycle arrest and halts tumor growth
Oncogenic signaling in cancer cells is essential for proliferation, and its disruption, either through inhibition or overactivation, can provide therapeutic opportunities. Dual specificity phosphatase 4 (DUSP4), a negative regulator of the MAPK pathway that dephosphorylates ERK, has been proposed as a potential target; however, its therapeutic relevance has not been evaluated in vivo. In this study, we show that DUSP4 knock-down induces G1 cell cycle arrest and reduces proliferation in BRAFV600E-mutant and BRAF inhibitor-resistant colorectal cancer models, both in vitro and in vivo, and induces a rapid DUSP5-mediated adaptive response. While treatment achieved tumor stasis indicating disease control, it did not yield tumor regression, suggesting that DUSP4 may have limited efficacy as a monotherapy target in cancer. ### Competing Interest Statement All authors are full time employees at Boehringer Ingelheim RCV.
https://www.biorxiv.org/content/10.64898/2026.01.15.699635v1
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Our preprint on DUSP4 in cancer is out. In vivo ARTi studies show DUSP4 loss doesn’t cause tumor regression and triggers fast, DUSP5-mediated compensatory reactivation. These results challenge DUSP4 as a monotherapy target. Link to preprint:
www.biorxiv.org/content/10.6...
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DUSP4 knockdown in BRAF V600E mutant colorectal cancer induces cell cycle arrest and halts tumor growth
Oncogenic signaling in cancer cells is essential for proliferation, and its disruption, either through inhibition or overactivation, can provide therapeutic opportunities. Dual specificity phosphatase 4 (DUSP4), a negative regulator of the MAPK pathway that dephosphorylates ERK, has been proposed as a potential target; however, its therapeutic relevance has not been evaluated in vivo. In this study, we show that DUSP4 knock-down induces G1 cell cycle arrest and reduces proliferation in BRAFV600E-mutant and BRAF inhibitor-resistant colorectal cancer models, both in vitro and in vivo, and induces a rapid DUSP5-mediated adaptive response. While treatment achieved tumor stasis indicating disease control, it did not yield tumor regression, suggesting that DUSP4 may have limited efficacy as a monotherapy target in cancer. ### Competing Interest Statement All authors are full time employees at Boehringer Ingelheim RCV.
https://www.biorxiv.org/content/10.64898/2026.01.15.699635v1
3 days ago
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Science-Fiction-Autor über KI: "Wir entscheiden selbst über Utopie oder Dystopie"
www.derstandard.at/story/310000...
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Science-Fiction-Autor über KI: "Wir entscheiden selbst über Utopie oder Dystopie"
Der Österreicher Ralph Neumüller räumt zum zweiten Mal in Folge den Deutschen Science-Fiction-Preis ab. Er will das Genre als gesellschaftliches Experimentierfeld sichtbarer machen
https://www.derstandard.at/story/3100000290862/science-fiction-autor-ueber-ki-wir-entscheiden-selbst-ueber-utopie-oder-dystopie?ref=article
3 months ago
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reposted by
Ralph Neumüller
Perrimon Lab
4 months ago
www.thecrimson.com/article/2025...
Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research
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Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research | News | The Harvard Crimson
FlyBase lost a multimillion dollar grant when the Trump administration cut off Harvard’s federal funding in May. Now the repository is laying off staff — and researchers worldwide are worried.
https://www.thecrimson.com/article/2025/9/9/flybase-funding/
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reposted by
Ralph Neumüller
Mark Peifer (He, him)
4 months ago
Thanks to journalist
@felixschmidtner.bsky.social
for bringing the plight of the key scientific database
@flybase.bsky.social
to a German/European audience
www.faz.net/aktuell/wiss...
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Die wichtigste Datenbank über die Fruchtfliege steht vor dem Aus.
Forscher weltweit sind auf eine zentrale Datenbank mit Erkenntnissen zu Drosophila angewiesen. Deren Finanzierung steht vor dem Aus. Wegen Donald Trump. Warum uns das nicht gleichgültig sein sollte.
https://www.faz.net/aktuell/wissen/die-wichtigste-datenbank-ueber-die-fruchtfliege-steht-vor-dem-aus-110676806.html
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reposted by
Ralph Neumüller
FlyBase
5 months ago
FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate:
wiki.flybase.org/wiki/FlyBase...
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FlyBase:Contribute to FlyBase - FlyBase Wiki
https://wiki.flybase.org/wiki/FlyBase:Contribute_to_FlyBase
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reposted by
Ralph Neumüller
Elizabeth McKenna
5 months ago
ICYMI last year in Cancer Discovery
@aacrjournals.bsky.social
: Zongertinib (BI 1810631), an Irreversible HER2 TKI, Spares EGFR Signaling and Improves Therapeutic Response in Preclinical Models and Patients with HER2-driven Cancers – by Birgit Wilding, Ralph Neumüller, et al.
doi.org/10.1158/2159...
add a skeleton here at some point
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reposted by
Ralph Neumüller
Ash Jogalekar
9 months ago
Novel carbodiimide warheads for aspartate covalent targeting. The field marches on.
pubs.acs.org/doi/abs/10.1...
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reposted by
Ralph Neumüller
Julia Grillmayr/Superscience Me/Science Fiction Book Club/LLC
11 months ago
Genau in einer Woche, 23.02. ab 14h, sind wir wieder im
@radioorange940.bsky.social
Studio und freuen uns über Eure Anrufe! Zu Gast ist
@ralphneumueller.bsky.social
dessen Roman "Das Stoffuniversum" wir besprechen. Es geht um Viele Welten, Einsamkeit und Chemie. Lest mit & ruft an!
#sciencefiction
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Der Soundtrack zu meinem Roman "Das zweigeteilte All" ist Nummer 1 der Österreichischen Indie Charts. Danke an Kommando Elefant 🤩
indiecharts.at
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indiecharts - Singles
Österreichs wöchentliche Independent-Charts, gevotet von den österreichischen Indie-DJs
https://indiecharts.at/
11 months ago
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Vielen Dank an die großartigen
@literatopia.bsky.social
für das Interview. Ich freue mich sehr, dass ich dabei sein durfte.
www.literatopia.de/index.php?op...
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Ralph Alexander Neumüller (13.02.2025)
Literatopia - eure Welt der Literatur! Rezensionen, Forum, Interviews, Events und vieles mehr ...
https://www.literatopia.de/index.php?option=com_content&view=article&id=28847:ralph-alexander-neumueller-13-02-2025&catid=48&Itemid=138
11 months ago
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Er ist da!! Der Soundtrack zu meinem neuen Roman "Das zweigeteilte All": "Traurige Maschinen" von Kommando Elefant. Check out the Video. Wie im Buch stehen Mensch-Maschine Interaktion im Fokus.😉
www.youtube.com/watch?v=tFC4...
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Kommando Elefant ft. Ralph Alexander Neumüller - Traurige Maschinen
YouTube video by kommandoelefant
https://www.youtube.com/watch?v=tFC42pQelK4
12 months ago
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Ich freu mich sehr darauf. Ein großartiger Science-Fiction Buchclub auf Radio Orange!🤩
add a skeleton here at some point
12 months ago
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reposted by
Ralph Neumüller
Radio ORANGE 94.0
12 months ago
Im nächsten Superscience Me Radio-Lesekreis wird "Das Stoffuniversum von
@ralphneumueller.bsky.social
besprochen. Buch besorgen, lesen, Radio einschalten, anrufen, mitreden ⬇️⬇️
add a skeleton here at some point
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reposted by
Ralph Neumüller
Norbert Kraut
about 1 year ago
Excited to see our paper in print in Cancer Discovery
@theaacr.bsky.social
@elizsmckenna.bsky.social
aacrjournals.org/cancerdiscov...
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Zongertinib (BI 1810631), an Irreversible HER2 TKI, Spares EGFR Signaling and Improves Therapeutic Response in Preclinical Models and Patients with HER2-Driven Cancers
Zongertinib, a covalent HER2 inhibitor, is active in HER2-driven preclinical models and patients and effectively targets HER2 oncogenic signaling while sparing wild-type EGFR, resulting in potent inhi...
https://aacrjournals.org/cancerdiscovery/article/15/1/119/750858/Zongertinib-BI-1810631-an-Irreversible-HER2-TKI
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