Fantastic to see @manifest-cirrp.bsky.social represented at Manchester Immuno-Oncology Network (MION) Spring Event. 🏥 🧬 Criticial work will be led by colleagues & co-investigators: 🐝 @cruk-mi.bsky.social 🐝 @mcrcnews.bsky.social 🐝 @cruknbc.bsky.social 🐝 The Christie

Privileged to have learnt so much from so many, and following in the footsteps 🐾 of giants! The true definition of #TeamScience 🧬 in the delivery of this work! Journey not over yet, and hopefully much more to come! @manifest-cirrp.bsky.social

#PubMed is down: a disaster for medicine and healthcare globally. It’s a critical tool to find medical data. I sincerely hope this is a temporary technical glitch and not reflective of the political change ongoing in the US.

🚨First output from the MANIFEST platform‼️ 🩸PBMC derived immune signatures can predict ICI response & tox! 🧑‍💻 Hugely collaborative effort led by @maxemmerichderm.bsky.social & Turajlic Lab in conjunction with #IMUBiosciences 📍Watch this space for multimodal composite biomarkers

Opportunity to reflect on the challenges of biomarker discovery in RCC‼️#GU25 Need for: 📊 Sample & Data Harmonisation 🔴 Overcome pervasive heterogeneity 🩸Incorporation of dynamic measures 🧠 Collaborative efforts ➡️ Generation of multimodal biomarker signatures 🧑‍💻: manifest-io.org.uk

🚨🧬A translational start to D3 #GU25 🧬🚨 Final Survival Analysis: COSMIC-313 💉Continued PFS benefit for the triplet of Ipi/Nivo/Cabo ❌ Nil OS Benefit ‼️ Triplet limited by Tox: ⬇️ ICI # No & Dose 🔬⬆️ M2 macrophages identifies a subgroup benefitting from triplet!

🔦 Spotlight on ctDNA as Biomarker in Bladder Ca. 🔴 Emerging role as a surrogate for path response & survival ‼️ Need for: 💉 Prospective efforts w/ embedded sampling timepoints 🧑‍💻 Combinatorial Biomarkers 📊 Data Harmonisation #GU25

🚨Follow @manifest-cirrp.bsky.social 🧬 Aiming to generate multimodal biomarker signatures incl & beyond ctDNA & PD-L1 expression in Bladder Ca 🧑🏾‍💻 manifest-io.org.uk #GU25

Fantastic discussant session from @erplimackmd.bsky.social this morning at #GU25 🔍 Role of peri-op IO in MIBC: #CM274 & #NIAGRA 🧬 Biomarker need to optimise stratification and minimise risk of over-treatment ➡️ Emerging risk adapted integrated biomarker driven studies (MODERN)

Excited to contribute to this space‼️ Critical to this will be a strong theme of cross-collaboration 🏥🧬 & knowledge-sharing 🧠 Great to see members of the consortium together at #Immuno25

Fantastic first trip up to @mcrcnews.bsky.social! Great to be a small part of a fantastic programme at #Immuno25 🏥🧑‍⚕️🧬 Reflecting the ongoing evolution across the Immune-oncology landscape 💊💉 Follow @manifest-cirrp.bsky.social to keep abreast of some of these developments!

#Immuno25 That’s a wrap 🙌! Such a fantastic day getting to discuss all about #CancerImmunotherapy, alongside fellow enthusiasts & friends. @zaydtippu.bsky.social @annaob.bsky.social @beckilee.bsky.social @ikshinchin1.bsky.social @mcrcnews.bsky.social

🚨Ongoing opportunities to join the @manifest-cirrp.bsky.social platform 🚨 ➡️ Join a growing team of computational & cancer biologists 💊Immune-Oncology Biomarker Discovery 📍@TurajlicLab @crick.ac.uk 🧑‍💻manifest-io.org.uk Link 👇

Researchers from the Crick have found that over 40% of variation in the way kidney cancer behaves is due to non-genetic factors. The findings were led by Angel Fernandez Sanroman with senior author Samra Turajlic www.crick.ac.uk/news-and-rep...

🌟 More exciting opportunities to join the @manifest-cirrp.bsky.social consortium at @crick.ac.uk! We are looking for: 💻 ML engineer 🔬 Senior Laboratory Research Scientist (Spatial Profiling) 🧑‍🔬 Senior Laboratory Research Scientist (Flow Cytometry) Apply now 👉 www.crick.ac.uk/careers-and-...

Already planning your calendar for 2️⃣ 0️⃣ 2️⃣ 5️⃣ ? 🐝 Why not visit us in Manchester & join us in our flagship #CancerImmunotherapy event. Programme now finalised & speakers confirmed 🤩! 🗓️ 2 days: 24 & 27 Jan 2025 (hybrid) To register (discount code - IMMUNO10): www.eventbrite.co.uk/e/the-cancer...

Too kind my friend! Attempting to follow in yours and the #MANIFEST consortium’s giant footsteps 🐾 Privileged to reperesent team MANIFEST, lots to come in 2025! 👩‍💻 manifest-io.org.uk 📧 [email protected]

Delighted to share the MANIFEST platform at #ESMOImmuno24 led by Samra Turajlic Builds on themes of 👨‍💻 Sample, assay & data harmonisation ➡️For generation of multi-modal/composite biomarkers 🚨Job opportunities across the platform! 👇 manifest-io.org.uk

Privileged to be here on behalf of the consortium 🧬 🏥 💊! Come and say 👋🏾 at Poster 40P! 👨🏾‍💻Additional info at manifest-io.org.uk #ESMOImmuno24

Gutted not to be Geneva 🇨🇭 for #ESMOImmuno24 in person this year 🥹. If you are presenting your work at #ESMOImmuno24, and potentially looking for a home for your research work, please consider submitting to our ESMO IOTECH journal: 🔗 esmoiotech.org

🎬 Fantastic start to #ESMOImmuno24 with ESMO-SITC primer. Highlighting challenges of IO biomarker discovery: 🔴 Heterogeneity in data, samples and assay types 🧬 Need for cross-study harmonisation & tailored composite biomarkers 💊 Neoadj. trials & PDTF’s offer opportunities for biomarker discovery!

🚨 Final call for this exciting opportunity to join the MANIFEST team (manifest-io.org.uk) 🏥 6 NHS Foundation Trusts 🧬 14 Academic Institutions 💊 Commercial Backing Opportunities to help shape and drive the programme! 👇🏾

Thrilled to contribute to this fantastic collaborative endeavour! 🎉 Massive kudos to the brilliant and the inspiring leadership of Samra Turajlic! @thecrick.bsky.social 🧬 🏥 📢 👀 Stay tuned for updates at www.manifest-io.org.uk.

🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov

New platform 🦋 ….but same excellent team 🩺👨🏽‍⚕️🧬 👇🏾Would highly recommend for any budding Phase 1 trialists/ cell therapy enthusiasts!

We are very excited to be hosting the super @asharpmedonc.bsky.social here in Manchester this Thu 21 Nov. 👨‍🔬 Targeting the intrinsic apoptosis pathway in lethal prostate cancer ⏰ 10:00-11:00 (Coffee from 09:45) Register & hear all the cool science he's doing 👇 www.eventbrite.co.uk/e/dr-adam-sh...

We're delighted to lead a new project with The Royal Marsden NHS Foundation Trust to study responses to cancer immunotherapy. The platform received £20m+ in public and industry investment and will involve thousands of people from across the UK receiving immunotherapy 🔗 crick.ac.uk/news-and-rep...

Privileged to have been a part of this hugely collaborative effort! 🎉 Huge plaudits to the MANIFEST partner-in-crime @drjonlim.bsky.social, under the visionary leadership of Samra Turajlic! 🧬 🏥 📢 👀 Watch this space, more info on www.manifest-io.org.uk

👋🏾 Tentative first steps into the 🦋 🌍 ! Couldn’t ask for better folks to be showing me the ropes! Looking forward to engaging on all things #MedSky & #AcademicSky 👨🏽‍⚕️ 🩺 🧬 🔬