Excited to share my first major internal research project at NEOsphere! Generating global proteomic profiles for entire cereblon glue libraries, we identified a degrader of the master cell cycle regulator CDK4.

Excited to share this preprint about the identification of TBK1 molecular glue degraders in a collaboration between NEOsphere Biotechnologies, @pmeier.bsky.social, and the Centre for Protein degradation @icr.ac.uk www.biorxiv.org/content/10.6...

This project started 5 years ago. It led us to add isotope-labeling support to #FragPipe/#IonQuant. Since then, the tools have grown so much and are now widely used in #Chemoproteomics. Huge thanks to everyone, and special thanks to @stephanhacker2.bsky.social and @pzanon.bsky.social

I am thrilled to see the paper out now and grateful to all coauthors for their contributions to this work! Among a number of changes, we included additional probes as well as experiments in live bacterial cells. So be sure to check it out even if you are already familiar with the preprint!

New powerful article up in the New York Times on cancelled and delayed grants www.nytimes.com/interactive/...

We are looking for a PhD candidate in medicinal / organic chemistry with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: jobs.univie.ac.at/job/Universi.... Reposts are very much appreciated!